Akt-Axin1/TNKS-Tiam1-Rac1 mediates insulin-stimulated GLUT4 translocation in skeletal muscle cells [0.03%]
Akt-Axin1/TNKS-Tiam1-Rac1介导胰岛素刺激的骨骼肌细胞GLUT4转位
Yingying Yue,Qiu Gu,Chang Zhang et al.
Yingying Yue et al.
It is known that insulin stimulates skeletal muscle glucose uptake via the InsR-IRS-PI3K pathway. The signaling downstream of PI3K is divided into the Akt-AS160-Rabs branch and the Rac1-actin cytoskeleton branches. These two signaling branc...
DOT1L promotes phenotypic transition of vascular smooth muscle cells following vascular injury in diabetes through activation of the FGFR4/PI3K/AKT/Jag/Notch signaling pathway [0.03%]
糖尿病血管损伤后DOT1L通过激活FGFR4/PI3K/AKT/Jag/Notch信号通路促进血管平滑肌表型转化
Jing Zhang,Di Wu,Chen Cheng et al.
Jing Zhang et al.
Vascular smooth muscle cell (VSMC) phenotypic transition contributes to restenosis, impacting the long-term efficacy of percutaneous coronary intervention in diabetic patients. While DOT1L is known to regulate atherosclerosis, its role in d...
Regulating the GTP cyclohydrolase 1/tetrahydrobiopterin axis in the distal tubule inhibits ferroptosis and alleviates crush syndrome-related acute kidney injury in mice [0.03%]
调节远端小管中的GTP环化酶1/四氢生物蝶呤轴抑制铁死亡并缓解小鼠挤压综合征相关的急性肾损伤
Li Zhang,Yuru Wang,Chunyan Zhang et al.
Li Zhang et al.
Ferroptosis in the proximal tubules has been implicated in the pathogenesis of crush syndrome-related acute kidney injury (CS-AKI). However, whether ferroptosis occurs in the distal tubules and the underlying mechanisms remain unclear. In n...
Idebenone alleviates rotenone-induced mitochondrial dysfunction through mitophagy and mitochondrial biogenesis in muscle cells [0.03%]
艾地苯通过线粒体自噬和生物生成缓解肌细胞中罗腾因诱导的线粒体功能障碍
Chen Zhang,Mei Li,Liying Meng et al.
Chen Zhang et al.
Idebenone, a synthetic quinone analog of coenzyme Q10, is a well-characterized antioxidant with clinical applications in treating diseases associated with mitochondrial dysfunction. However, it remains unclear whether idebenone can mitigate...
ERLIN1: A central regulator of protein quality control, lipid homeostasis, and cellular signaling at the endoplasmic reticulum [0.03%]
埃尔林1：内质网蛋白质质量控制、脂质稳态和细胞信号转导的核心调节因子
Hyojeong Cho,Beomwoo Lee,Changgyu Son et al.
Hyojeong Cho et al.
Endoplasmic reticulum lipid raft-associated protein 1 (ERLIN1) is an endoplasmic reticulum (ER)-resident stomatin/prohibitin/flotillin/HflK/C (SPFH) family protein that assembles into oligomeric complexes within detergent-resistant membrane...
Ferroptosis in reproductive system disorders: Pathological roles and therapeutic potential [0.03%]
铁死亡在生殖系统疾病中的病理作用和治疗潜力
Shuai Guo,Shuai Wang,Cai Zhang et al.
Shuai Guo et al.
Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ ...
Ferroptosis modulation by METTL14 in cancers: From molecular insights to therapeutic strategies [0.03%]
METTL14在癌症中的铁死亡调控：从分子机制到治疗策略
Boran Huang,Chenglin Zhu,Xinyu Zhang et al.
Boran Huang et al.
Ferroptosis is an iron-dependent, lipid peroxidation-driven form of regulated cell death that is mechanistically distinct from apoptosis and necrosis. In cancer, it plays a dual role: it can act as a tumor suppressor mechanism, yet may also...
DTX3L promotes renal cell carcinoma progression via ubiquitination and degradation of LATS2 [0.03%]
DTX3L通过泛素化和降解LATS2促进肾细胞癌进展
Yeqing Yuan,Bin Lyu,Zhimin Chu et al.
Yeqing Yuan et al.
Renal cell carcinoma (RCC) remains a therapeutic challenge due to incomplete understanding of its molecular drivers. This study identifies DTX3L as a novel oncogenic E3 ubiquitin ligase in RCC through comprehensive multi-omics analysis. We ...
Cancer-associated fibroblasts: The "Achilles' Heel" in thyroid tumor progression and therapy [0.03%]
癌相关成纤维细胞：甲状腺肿瘤进展和治疗的“阿喀琉斯之踵”
Xiaoxiao Li,Hengtong Han,Shouhua Li et al.
Xiaoxiao Li et al.
Growing evidence indicates that the complex and heterogeneous tumor microenvironment (TME) beyond the tumor cells plays a pivotal role in cancer development and therapy. Notably, cancer-associated fibroblasts (CAFs)-a key stromal cell popul...
LNC511 inhibits lung cancer progression by modulating the miR-625/LOXL4/Wnt/β-catenin pathway [0.03%]
LNC511通过调控miR-625/LOXL4/Wnt/β-catenin信号通路抑制肺癌进展
Daifang Chu,Hua Zong,Yangyang Duan et al.
Daifang Chu et al.
Lung cancer (LC) is a major contributor to cancer-related deaths worldwide, and long noncoding RNAs (lncRNAs) play significant roles in cancer progression. This study focused on the lncRNA LNC511 and its impact on LC cell activity. Through ...