Evolving perspectives on lipid mediated cell-to-cell communication: The adenylyl cyclase signaling system [0.03%]
脂质介导的细胞间信号转导的观点演变——腺苷酸环化酶信号系统
Joachim E Schultz
Joachim E Schultz
Decades after the discovery of the second messenger cyclic AMP, the regulation of multi-domain adenylyl cyclases remains poorly understood. Mammals express nine membrane-bound isoforms which share an identical domain architecture. These mAC...
CUEDC2 improves pyroptosis and kidney damage in diabetic kidney disease by inhibiting NLRP3 inflammasome activation [0.03%]
CUEDC2通过抑制NLRP3炎性小体活化改善糖尿病肾病的细胞焦亡和肾脏损伤
Peiyuan Yang,Liming Fan,Daijiao Yuan et al.
Peiyuan Yang et al.
Diabetic kidney disease (DKD) is highly prevalent worldwide, and its incidence continues to rise annually. Hyperglycemia, fatty acids, and other damage-related molecules are detected by specific pattern recognition receptors (PRRs), thereby...
PKA signaling meets ferroptosis: A new perspertive in cancer treatment [0.03%]
蛋白激酶A信号通路与铁死亡相互作用在癌症治疗中的新视角研究
Hao Liu,Shanliang Zheng,Olga Burenina et al.
Hao Liu et al.
Emerging evidence highlights ferroptosis - a recently identified iron-dependent form of regulated cell death - as a promising therapeutic approach for tumor suppression and treatment optimization. Notably, Protein Kinase A (PKA), a central ...
Corrigendum to "Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/β-catenin pathway" [Cellular Signalling, 116 (2024) 111042] [0.03%]
关于“醛氧化酶1通过ROS介导的Wnt/β-连环蛋白信号通路激活促进胆囊癌发生”的勘误[细胞信号转导，116 (2024) 111042]
Ziheng Yuan,Genfa Yi,Run Ma et al.
Ziheng Yuan et al.
Published Erratum
Cellular signalling. 2025 Nov 12:112219. DOI:10.1016/j.cellsig.2025.112219 2025
Corrigendum to "Ginsenoside inhibits aerobic glycolysis in hepatocellular carcinoma through the hsa-miR-139-5p/AURKA axis" [Cellular Signalling 136 (2025) 112177] [0.03%]
关于“ Ginsenoside通过hsa-miR-139-5p/AURKA轴抑制肝癌细胞的糖酵解”一文的勘误[《信号转导》（136卷，2025年，112177页）]
Xiaoping Wei,Hong Zhu,Tiehan Li et al.
Xiaoping Wei et al.
Published Erratum
Cellular signalling. 2025 Nov 11:112215. DOI:10.1016/j.cellsig.2025.112215 2025
The molecular mechanisms of cuproptosis and its role in central nervous system diseases [0.03%]
铜死亡的分子机制及其在中枢神经系统疾病中的作用
Mingyuan Xu,Yumei An,Xiaoyan Liu et al.
Mingyuan Xu et al.
Copper is an essential micronutrient in the brain, serving as a critical enzymatic cofactor indispensable for neuronal function and homeostasis. In recent years, cuproptosis, a new regulated form of cell death mechanistically distinct from ...
NSUN3-mediated m5C modification of FABP5 regulates lipid droplets through autophagy to alleviate osteoarthritis progression [0.03%]
NSUN3介导的FABP5m5C修饰通过自噬调节脂滴以缓解骨关节炎进展
Ziwei Luo,Yuanxian Liu,Baorong Cheng et al.
Ziwei Luo et al.
Lipid droplets (LDs) are closely associated with the onset and progression of osteoarthritis (OA). RNA 5-Methylcytosine (m5C) modification plays a key role in various diseases, but its role in the pathogenesis of OA is largely unknown. In t...
Caveolin-1 drives vasculogenic mimicry in lung adenocarcinoma through autophagy-mediated glycolytic reprogramming [0.03%]
Caveolin-1通过自噬介导的糖酵解重构促进肺腺癌血管生成模拟现象
Lifang Zhang,Xinrui Liu,Xiaoan Zhang et al.
Lifang Zhang et al.
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, characterized by limited therapeutic options and poor prognosis. Caveolin-1 (Cav-1), a key structural protein of caveolae, has been implicated in multiple oncog...
LRP1 regulates GDNF secretion and perineural invasion in pancreatic cancer via PI3K/AKT signaling [0.03%]
LRP1通过PI3K / AKT信号传导调节胰腺癌中的GDNF分泌和神经周围侵袭
Songmei Lou,Shenhao Liu,Mengying Zhu et al.
Songmei Lou et al.
Pancreatic cancer induces intense abdominal pain through the infiltration of cancer cells into surrounding nerve tissues, leading to sensory neuron damage. The research aims to identify pivotal molecules involved in PNI, contributing to cli...
Transcriptional and post-transcriptional convergence of HES1 and IGF2BP2 sustains CSF2-dependent metabolic adaptability in gastric Cancer [0.03%]
HES1和IGF2BP2的转录与后转录汇聚作用可持续介导CSF2依赖性代谢适应性以促进胃癌发展
Jun Du,Lei Li,Bangling Chen et al.
Jun Du et al.
This study delineates a hierarchical signaling axis driving gastric cancer (GC) progression through integrated transcriptomic and functional analyses. Single-cell sequencing and TCGA data identified CSF2 as a key oncogene, with elevated exp...