Integrative multi-omics reveals a fibroblast-centered, ZFHX3-prioritized regulatory framework linking sick sinus syndrome and atrial fibrillation [0.03%]
整合多组学揭示连接窦性节律异常和房颤的以成纤维细胞为中心、ZFHX3为核心的调控网络框架
Zhaoqi Yan,Xiangyi Pu,Yongyuan Cai et al.
Zhaoqi Yan et al.
Objective: To define shared genetic and multi-scale mechanisms underlying comorbidity between sick sinus syndrome (SSS) and atrial fibrillation (AF). Meth...
Progressive mitochondrial and autophagic dysfunction during RGC development driven by a LHON-associated mitochondrial tRNAThr mutation [0.03%]
由LHON相关线粒体tRNAThr突变驱动的视网膜神经节细胞发育过程中渐进性的线粒体和自噬功能障碍
Wei Guan,Wenxu Li,Zijun Li et al.
Wei Guan et al.
Leber's hereditary optic neuropathy (LHON) is a genetically inherited disease of the eye triggered by mtDNA mutations, leading to degeneration of RGCs. We previously reported that the mitochondrial tRNAThr (MT-TT) 15927G > A homoplasmic mut...
Mogroside V inhibits high glucose-induced inflammatory responses and promotes osteogenic differentiation in diabetic osteoporosis via the PI3K/Akt/mTOR pathway [0.03%]
罗汉果酸V通过PI3K/Akt/mTOR信号通路抑制高糖诱导的炎症反应及促进糖尿病性骨质疏松小鼠成骨分化
Zhao Wang,Huwei Bian,Haibo Wang et al.
Zhao Wang et al.
Background: Osteoblast dysfunction induced by high glucose (HG) environment plays a key role in diabetic osteoporosis (DOP) pathogenesis, but effective intervention strategies are still limited. Mogroside V (Mog V), a nat...
Targeting the AMPK signalling pathway: Honokiol modulated energy metabolism to mitigate pulmonary injury induced by airborne microplastics through regulating autophagy and mitophagy [0.03%]
靶向AMPK信号通路：Honokiol通过调节自噬和线粒体自噬缓解气溶胶微塑料诱导的肺损伤并改善能量代谢
Yajing Ma,Ruisi Zhu,Songyuan Xia et al.
Yajing Ma et al.
Microplastics (MPs) pollution represents a pressing global environmental challenge, with studies increasingly highlighting their associated health risks. Although MPs have been detected in human lung tissues, the majority of existing resear...
Xinkai Pang,Tong Liu,Jiayu Xin et al.
Xinkai Pang et al.
Although neuromodulation has emerged as a critical factor in cancer biology, its involvement in cervical cancer remains largely unexplored. In this study, we identified the serotonin transporter (SERT), a marker of serotonergic neurons, as ...
TBX1 suppresses colorectal cancer cells via PPP2R2B-mediated inhibition of MAPK/ERK and PI3K/AKT pathways [0.03%]
TBX1通过PPP2R2B介导的MAPK/ERK和PI3K/AKT信号通路抑制 colorectal 癌细胞
Man Zhao,Jun Wang,Jing Yi Xie et al.
Man Zhao et al.
Background: Methods: To assess the impact of TBX1 on the proliferation and colony-forming capacity of colorectal cancer cells, in vitro functional investigations were carried out. Concurrently, a subcutaneous xenograft mo...
Network pharmacology and experimental validation reveal the therapeutic effect and Chemosensitization mechanism of Brusatol against oral squamous cell carcinoma [0.03%]
网络药理学和实验验证揭示Brusatol对口腔鳞状细胞癌的治疗效果及增敏机制
Danfeng Xue,Wei Li,Fei Yu et al.
Danfeng Xue et al.
Brusatol (BR) is a quassinoid from the traditional Chinese herb Brucea javanica, widely used for its anti-inflammatory and anti-tumor properties. This study aimed to investigate the molecular mechanisms through which BR overcomes cisplatin ...
A combined stimulus of acute fasting and exercise modulates hippocampal mitochondrial quality control in healthy mice [0.03%]
急性禁食和运动联合刺激可调节健康小鼠海马体线粒体质量控制
Vivien Csikos,Brittany Hauger,Taylor Strope et al.
Vivien Csikos et al.
Background and aims: Exercise and fasting are recognized for their ability to improve brain health and mitigate neurodegeneration. However, little is known about how these interventions acutely impact mitochondrial qualit...
The multifaceted role of cathepsin a in glioblastoma pathogenesis: from molecular scaffolding to immunological evasion [0.03%]
猫溶酶体组织蛋白酶A在胶质母细胞瘤发生发展中的作用机制研究：从分子支架到免疫逃逸
Jaeseok Choi,Beomwoo Lee,Changgyu Son et al.
Jaeseok Choi et al.
Glioblastoma (GBM) is a highly aggressive primary central nervous system malignancy characterized by pronounced intratumoral heterogeneity, rapid progression, and resistance to standard therapeutic approaches. Increasing evidence indicates ...
TCTP regulates the infiltration of CXCR4+ immunosuppressive cells in cervical Cancer via the non-canonical NF-κB/ZEB1/CXCL12 Axis [0.03%]
TCTP通过非经典NF-κB/ZEB1/CXCL12轴调节宫颈癌中CXCR4+免疫抑制细胞的浸润
Shaoju Min,Yurong Zhu,Luhong Xie et al.
Shaoju Min et al.
The immunomodulatory factor translationally controlled tumor protein (TCTP) drives tumor progression by inducing an immunosuppressive microenvironment; however, its specific role and underlying mechanisms in cervical cancer (CC) remain unch...