α-KG alleviates mitochondrial dysfunction and attenuates HPDLSCs senescence in periodontitis through LKB1-AMPK activation [0.03%]
α-酮戊二酸通过LKB1-AMPK激活缓解牙周病的线粒体功能障碍及人牙周膜干细胞衰老
Xin Zhang,Lingshuang Li,Hongrui Liu et al.
Xin Zhang et al.
Periodontitis is a chronic inflammatory disease characterized by persistent inflammation that induces senescence and functional impairment of human periodontal ligament stem cells (HPDLSCs), thereby hindering periodontal regeneration. Mitoc...
GNE-493 suppresses gastric cancer development by targeting NAT10-mediated ac4C modification of HK2 [0.03%]
GNE-493通过靶向NAT10介导的HK2的ac4C修饰抑制胃癌发生
Tengkai Wang,Junling Zhen,Qingao Wei et al.
Tengkai Wang et al.
Gastric cancer is one of the most common primary malignant tumors of the digestive system. Chemoresistance remains a major obstacle in the clinical management of gastric cancer, and targeting the metabolic reprogramming of tumor cells has e...
USP43 promotes lymphatic metastasis of bladder cancer by regulation of ZBTB7A [0.03%]
USP43通过调控ZBTB7A促进膀胱癌淋巴转移
Jiabao Gao,Yanchun Pan,Quan Cheng et al.
Jiabao Gao et al.
Lymphatic metastasis is the most common route of dissemination in bladder cancer and is closely associated with poor clinical outcomes, posing a major challenge to effective treatment. Therefore, identifying the key initiators and regulator...
A novel role of follicular fluid chemokine CCL21 in promoting porcine oocyte in vitro maturation through activating ERK1/2 signaling pathway [0.03%]
新型卵泡液细胞趋化因子CCL21通过激活ERK1/2信号途径促进猪卵母细胞体外成熟的作用机制研究
Ruohan Mei,Zhihao Wang,Fanglong Bi et al.
Ruohan Mei et al.
Follicular fluid (FF) is recognized for its ability to enhance oocyte in vitro maturation (IVM), yet the specific factors responsible for this effect remain largely unidentified. In this study, 44 extracellular specifically expressed protei...
P4HA2 promotes glioma cell proliferation by interacting with Hsp27 to activate the EGFR/ERK signaling pathway [0.03%]
热休克蛋白27结合促进P4HA2激活EGFR/ERK信号通路并诱导胶质瘤细胞增殖
Hongqing Cai,Qi Liu,Liyan Yang et al.
Hongqing Cai et al.
Background: Gliomas have a poor prognosis and limited therapeutic options, so there is an urgent need to find new therapeutic targets. P4HA2 promotes tumor progression by enhancing cell proliferation and extracellular mat...
Glycoprotein non-metastatic melanoma protein B promotes pyroptosis of macrophages induced by homocysteine associated with the upregulation of the NOX-2/ NF-κB signaling pathway [0.03%]
同型半胱氨酸通过NOX-2/NF-κB信号通路上调诱导巨噬细胞焦亡促进 glycoprotein non-metastatic melanoma protein B蛋白质的表达
Xuhong Zhang,Tian Tian,Ping Cao et al.
Xuhong Zhang et al.
Elevated homocysteine (Hcy) levels are well established as an independent risk factor for atherosclerosis and its associated cardiovascular diseases. Macrophage pyroptosis- mediated inflammation plays a crucial role in the progression of at...
Adhesion molecule with Ig-like domain 1 regulates stability of carotid plaque via TGFβ/Smad signaling pathway by interaction with TGFRII [0.03%]
含有Ig样结构域的粘附分子1通过与TGFRII相互作用调控动脉粥样硬化斑块稳定性的机制研究
Xintao Hu,Xiaoqing Li,Jichong Chen et al.
Xintao Hu et al.
Carotid atherosclerosis is a significant risk factor for cardiovascular and cerebrovascular diseases. Maintaining plaque stability can prevent plaque rupture and thrombus formation, slow disease progression, and is critically important for ...
The Wnt signaling pathway plays a key role in regulating the pluripotent state of rbESCs and promoting their commitment to the primordial germ cell fate [0.03%]
Wnt信号通路在调控rbECSs多能性及其向原始生殖细胞命运决定中起关键作用
Yongmei Wu,Ziyan Gao,Ruimen Zhang et al.
Yongmei Wu et al.
Research on in vitro gametogenesis (IVG) provides novel approaches to the investigation of germ cell development mechanisms and the conservation of elite livestock germplasm resources. Rabbits are an ideal animal model and highly suitable f...
VDAC1-mediated cytosolic leakage of mtDNA triggers pyroptosis of nucleus pulposus cells by activating the TLR9 signaling pathway [0.03%]
线粒体通透转子蛋白1介导的细胞质mtDNA泄漏通过激活Toll样受体9信号途径触发椎间盘髓核细胞焦亡
Tonglong Hu,Miaoheng Yan,Yangyang Chen et al.
Tonglong Hu et al.
Programmed cell death, particularly pyroptosis mediated by inflammatory signaling pathways, plays a critical role in the pathogenesis of intervertebral disc degeneration (IVDD). However, the regulatory mechanisms underlying pyroptosis and i...
SIRT1 agonist SRT1720 alleviates cerebral ischemia-reperfusion injury by inhibiting lactate-mediated SOD2 Lactylation and suppressing NCOA4-mediated ferritinophagy-ferroptosis [0.03%]
SIRT1激动剂SRT1720通过抑制乳酸介导的辅酶Q限制性亚铁血红素氧化酶双加氧酶2乳酰化和NCOA4介导的铁死亡FERROPTOSIS缓解脑缺血再灌注损伤
Xue Qi,Wenqin Song,Yanan Li et al.
Xue Qi et al.
Cerebral ischemia-reperfusion injury (CIRI) represents a critical pathological process underlying stroke-induced neuronal loss and long-term neurological deficits, characterized by profound oxidative stress and dysregulated iron homeostasis...