PLK1 inhibition by Shikonin attenuates oral cancer growth through β-catenin-mediated regulation of EMT and apoptosis [0.03%]
漆酚通过PLK1抑制调节EMT和凋亡从而缓解口腔癌增长
Stuti Biswal,Sruti Biswal,Bibekanand Mallick et al.
Stuti Biswal et al.
Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy characterized by poor prognosis, frequent recurrence, and limited effective therapeutic options. Shikonin (Shk), a bioactive naphthoquinone derivative isolated from the r...
COL1A1 promotes clear cell renal cell carcinoma progression through the Wnt/β-catenin signaling pathway [0.03%]
COL1A1通过Wnt/β-catenin信号通路促进透明细胞肾细胞癌的发展进展
Xing Ji,Yongyang Yun,Zhenpeng Zhu et al.
Xing Ji et al.
Objective: To investigate COL1A1 expression, prognostic significance, functional roles, and underlying mechanisms in clear cell renal cell carcinoma (ccRCC). ...
Melatonin counteracts Iodoacetic acid induced ferroptosis by regulating Nrf2 in porcine oocytes [0.03%]
褪黑素通过调节Nrf2对抗疏基乙酸诱导的小鼠卵母细胞铁死亡的作用
Qin-Yue Lu,Cheng-Lin Zhan,Song-Hee Lee et al.
Qin-Yue Lu et al.
Environmental contaminants pose a significant threat to mammalian reproduction by disrupting follicular development and oocyte maturation. Iodoacetic acid (IAA), an unregulated disinfection byproduct (DBP) found in drinking water, has been ...
DHCR24 knockdown-induced cellular cholesterol deficiency triggers tau hyperphosphorylation at Thr181, Ser199 and Ser202/Thr205 via p38 MAPK/JNK signaling [0.03%]
DHCR24敲低诱导的细胞胆固醇缺乏通过p38MAPK / JNK信号触发Tau在Thr181，Ser199和Ser202 / Thr205处过度磷酸化
Mengqi Zhang,Wenshi Wei,Hengbing Zu
Mengqi Zhang
Cholesterol deficiency is implicated in Alzheimer's disease (AD) pathogenesis, yet its regulatory role in tau phosphorylation remains unclear. We investigated whether the loss of 24-dehydrocholesterol reductase (DHCR24), a key enzyme in cho...
NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification [0.03%]
NCAPG通过NSUN2介导的m5C修饰赋予肝细胞癌铁死亡抵抗性
Zhihao Huang,Jiakun Wang,Aoxiao He et al.
Zhihao Huang et al.
Ferroptosis is considered as a promising strategy for treatment of hepatocellular carcinoma (HCC) due to its susceptibility. However, ferroptosis-based treatment is rarely discussed in clinical application, which is closely correlated with ...
ACSL4 coordinates metabolic and cell cycle reprogramming to promote endometrial cancer progression [0.03%]
ACSL4通过协调代谢和细胞周期重编程来促进子宫内膜癌进展
Hongtao Guo,Yitong Ma,Liangjian Ma et al.
Hongtao Guo et al.
Endometrial cancer (EC) is a common gynecologic malignancy associated with lipid metabolic reprogramming. We identified ACSL4, a fatty acid-activating enzyme, as significantly upregulated in EC and inversely correlated with tumor differenti...
Targeting LINC02613 to inhibit oral squamous cell carcinoma metastasis and progression via the rehabilitation of LCP1 ubiquitination [0.03%]
靶向长链非编码RNA LINC02613通过恢复LCP1泛素化抑制舌鳞状细胞癌的转移和进展
Qiming Jiang,Nan Lu,Rui Chen et al.
Qiming Jiang et al.
Lymph node metastasis of tumors is an important adverse factor affecting the long-term prognosis of patients with oral squamous cell carcinoma (OSCC). In recent years, the abnormal expression of long noncoding RNAs (lncRNAs) has gained atte...
Features and functional mechanisms of super-enhancers in cardiovascular disorders, cancer, autoimmune diseases and neurodegenerative disorders [0.03%]
表观遗传调控元件超级增强子在心血管疾病、癌症、自身免疫病和神经退行性疾病中的功能特征及机制研究进展
Zi-Rong Li,Yong-Yan Wang,Chao Zhang et al.
Zi-Rong Li et al.
Super-enhancers (SEs) constitute specialized genomic regulatory hubs defined by high density agglomeration of transcriptional machinery, transcription factors (TFs), and chromatin-modifying complexes. These higher order chromatin architectu...
TLR2 signalling triggers NLRP3 inflammasome-mediated microglial pyroptosis promotes neonatal hypoxic-ischemic brain injury [0.03%]
TLR2信号触发NLRP3炎症小体介导的小胶质细胞细胞焦亡促进新生儿缺氧缺血性脑损伤
Fei Ruan,Wei Bao,Jing Hu et al.
Fei Ruan et al.
Neonatal hypoxic-ischemic encephalopathy (HIE) causes severe neurological damage. The extensive cell death and subsequent inflammation observed in the brain following hypoxic-ischemic (HI) injury suggest that pyroptosis, an inflammation-ass...
Corrigendum to "Downregulation of miR-27a-3p induces endothelial injury and senescence and its significance in the development of coronary heart disease" [Cellular Signalling, 131(2025) 111759] [0.03%]
关于“下调miR-27a-3p诱导内皮损伤和衰老及其在冠心病发病中的意义”的勘误[细胞信号转导期刊，131（2025）111759]
Chong-Yang Song,Hai-Zhen Huang,Ting-Ting Yan et al.
Chong-Yang Song et al.
Published Erratum
Cellular signalling. 2025 Nov 17:112242. DOI:10.1016/j.cellsig.2025.112242 2025