The effects of Metformin on myocardial ischemia and reperfusion injury in diabetic rats and its potential mechanism [0.03%]
二甲双胍对糖尿病大鼠心肌缺血再灌注损伤的影响及机制研究
Yunna Ma,Zhe Jin,Yanlin Wang et al.
Yunna Ma et al.
Diabetic cardiovascular disease remains the leading cause of mortality in patients with diabetes, underscoring the urgent need for effective therapeutic strategies to improve clinical outcomes and prevent major adverse cardiovascular events...
CaMKIIγ inhibition attenuates osteoclastogenesis via the NF-κB-NFATc1 axis and protects against ovariectomy-induced osteoporosis [0.03%]
钙调神经磷酸酶抑制子γ通过NF-κB-NFATc1轴抑制破骨细胞生成并预防卵巢切除术诱导的骨质疏松症
Yisen Qiu,Ningnan Fang,Bang An et al.
Yisen Qiu et al.
Osteoporosis features excessive osteoclast-mediated bone resorption, and long-term safety concerns with current antiresorptives and rebound after discontinuation underscore the need for new therapeutic targets. Calcium/calmodulin-dependent ...
Nuclear localized p70S6K maintain cancer stem-like properties by modulating RPA3 activity in osteosarcoma [0.03%]
p70S6K核定位通过调节RPA3活性维持骨肉瘤干细胞样特性
Jing Zhou,Bo Li,Qi Gao et al.
Jing Zhou et al.
Cancer stem-like cells (CSCs) are believed to be a pivotal contributor to therapy failure in various cancers including osteosarcoma. Targeting CSCs is a promising strategy to overcome chemoresistance and improve outcomes in osteosarcoma tre...
The SLC35B2/YAP1 axis contributes to the inhibitory effects of CLIC-2-overexpressing cancer-associated fibroblast-derived exosomes on gastric cancer progression [0.03%]
SLC35B2/YAP1轴贡献了CLIC-2过表达癌症相关成纤维细胞衍生的外泌体对胃癌进展的抑制作用
Xiliang Cong,Xijie Zhang,Hang Yang et al.
Xiliang Cong et al.
Cancer-associated fibroblasts (CAFs) are key regulators of tumor progression within the gastric cancer microenvironment. Chloride Intracellular Channel-2 (CLIC-2), a member of the CLIC protein family, has been implicated in tumor biology. H...
APOC1 in tumor-associated macrophages enhances protumorigenic M2 polarization and promotes PAAD progression [0.03%]
肿瘤相关巨噬细胞中的APOC1通过增强促肿瘤的M2极化来促进胰腺癌进展
Yue Wang,Qing Gao,Yan Xie et al.
Yue Wang et al.
Apolipoprotein C1 (APOC1) is aberrantly overexpressed in multiple cancers, but its role in pancreatic adenocarcinoma (PAAD) and the tumor microenvironment remains unclear. Here, we investigated the expression and function of APOC1 in tumor-...
Tumor-derived extracellular vesicles-mediated oxidative stress transfer activates glycometabolic reprogramming of CAFs [0.03%]
肿瘤来源的细胞外囊泡介导的氧化应激转移激活癌相关成纤维母细胞的糖代谢重编程
Erhui Jiang,Xiang Li,Xinyu Dou et al.
Erhui Jiang et al.
Background: In the adverse tumor microenvironment excessive tumor cell proliferation is accompanied by massive reactive oxygen species (ROS) production. Though tumor-derived extracellular vesicles (TEVs) have confirmed ro...
Maresin1 alleviates inflammation and improves extracellular matrix regeneration after intervertebral disc degeneration [0.03%]
maresin1可在椎间盘退变后减轻炎症和促进细胞外基质的再生
Hui Wang,Xiangyu Li,Tao Yan et al.
Hui Wang et al.
Intervertebral disc degeneration (IVDD) is characterized by excessive inflammation and extracellular matrix (ECM) degradation in the nucleus pulposus (NP), with limited current therapeutic options. Specialized pro-resolving mediators (SPMs)...
Extracellular Vimentin signaling in periodontitis and rheumatoid arthritis with special focus on leucine-rich repeat containing 15 binding [0.03%]
牙周炎和类风湿关节炎中细胞外波形蛋白信号传导及亮氨酸富集重复序列包含15与之结合的研究
Claire X Yang,Masoud Norouzi,Mark Abovsky et al.
Claire X Yang et al.
Inflammatory diseases of connective tissues such as periodontitis and rheumatoid arthritis exhibit localized destruction of matrix collagen and loss of tissue function. These diseases are driven by interconnected signaling pathways that det...
Smyd1 signaling activation improves mitochondrial function and reduces diabetes-associated atrial fibrillation by enhancing PGC-1α signaling pathway [0.03%]
Smyd1信号激活通过增强PGC-1α信号通路改善线粒体功能并减少糖尿病相关房颤
Yuan Wang,Li Zhu,Xinyi Huang et al.
Yuan Wang et al.
Muscle-specific histone methyltransferase 1 (Smyd1) is required for skeletal and cardiac muscle development, yet its roles and mechanisms in diabetes-associated atrial fibrillation (AF) remain poorly defined. This study aims to elucidate th...
METTL14-mediated m6A modification of CCNE1 accelerates progression of myelodysplastic syndromes via MAPK-ERK and PI3K-AKT signaling pathways [0.03%]
METTL14介导的CCNE1m6A修饰通过MAPK-ERK和PI3K-AKT信号通路加速骨髓增生异常综合征的发展
Xiaolin Liang,Jiamin Luo,Yiqian Huang et al.
Xiaolin Liang et al.
Background: N6-methyladenosine (m6A) is the most common RNA modification and plays a key role in the initiation, progression, and relapse of multiple cancers, including hematologic malignancies. However, the role of m6A a...