Set7 regulates ferroptosis in pulmonary arterial hypertension endothelial cells through the DPP4/NOX4 axis mediated by H3K4me1 modification [0.03%]
SET7通过组蛋白H3K4me1修饰介导的DPP4/NOX4轴调节肺动脉高压内皮细胞铁死亡
Jingyuan Chen,Yusi Chen,Wenjie Chen et al.
Jingyuan Chen et al.
Objective: Dipeptidyl peptidase-4 (DPP4)-targeted therapy is widely employed in the therapy of pulmonary diseases, but the role of its H3K4me1 modification in pulmonary arterial hypertension (PAH) disease remains unknown....
The miR-7 family: an evolutionary conservation and multifunctional miRNA family [0.03%]
miR-7家族：一个进化保守且功能多样的microRNA家族
Liting Bao,Chen Wang,Yiqing He et al.
Liting Bao et al.
microRNAs (miRNAs) are a class of non-coding RNA molecules that regulate biophysiological and biochemical processes by modulating gene expression. miR-7 is widespread and sequence conserved across species. Due to its conserved sequence and ...
JAM3 orchestrates Mac-1-dependent AKT phosphorylation to facilitate neutrophil extracellular trap-driven meningioma pathogenesis [0.03%]
JAM3通过调节Mac-1依赖的AKT磷酸化来促进中性粒细胞胞外陷阱诱导的脑膜瘤发生发展
Jing Zhang,Yipeng Dong,Xianghua Zhang et al.
Jing Zhang et al.
Despite the documented involvement of neutrophil extracellular traps (NETs) in various cancer types, their specific role in meningioma development remains understudied. Here, we report a mechanism by which the JAM3/Mac-1 interaction promote...
Cordycepin alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial oxidative stress and apoptosis through modulation of the PI3K/Akt/mTOR pathway [0.03%]
虫草素通过调节PI3K/Akt/mTOR信号途径减轻脓毒症诱导的心肌病及线粒体氧化应激和凋亡
Qian Yu,Zilin Liu,Jiangtao Yu et al.
Qian Yu et al.
Objective: Sepsis-induced cardiomyopathy (SICM) is a frequent and life-threatening complication of sepsis, characterized by acute cardiac dysfunction and high mortality, yet no specific therapy is currently available. Cor...
Nuclear SIRT6 depletion activates LINE1-cGAS-STING pathway to induce PASMCs senescence in hypoxic pulmonary hypertension [0.03%]
缺氧性肺动脉高压中核SIRT6耗尽激活LINE1-cGAS-STING通路诱导肺动脉平滑肌细胞衰老
Meng Wang,Meiling Zhang,Jian Chen et al.
Meng Wang et al.
Hypoxic pulmonary hypertension (HPH) is a complex vascular disease that is difficult to reverse in its advanced stages and has a poor prognosis. Senescent pulmonary artery smooth muscle cells (PASMCs) had been shown to secrete senescence-as...
KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation [0.03%]
KMN003通过破坏Keap1-Nrf2相互作用及p38依赖性转录调控活化Nrf2
Keijiro Komeda,Kai Toyoshima,Daisuke Yasuda et al.
Keijiro Komeda et al.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that plays a crucial role in cellular defenses against oxidative stress and inflammation. Under normal conditions, Kelch-like ECH-associated protein 1 (Keap1), a u...
The ceRNA network of LINC00536/miR-204-5p/TGFBR2: A novel therapeutic target for breast cancer diagnosis and treatment [0.03%]
LINC00536/miR-204-5p/TGFBR2 ceRNA网络：乳腺癌诊断和治疗的新靶点
Tayier Tuersong,Munire Shataer,Dilare Lidifu et al.
Tayier Tuersong et al.
Background: Long non-coding RNAs (lncRNAs) act as competing endogenous RNAs (ceRNAs) to regulate tumor progression, yet the role of LINC00536 in breast cancer (BC) remains unclear. This study investigates the oncogenic fu...
Puerarin protects against renal ischemia-reperfusion injury by restoring mitochondrial function and modulating the PI3K/AKT/NF-k B pathway and suppressing inflammatory responses [0.03%]
葛根素通过恢复线粒体功能和调节PI3K / AKT / NF-κB通路和抑制炎症反应来保护肾脏缺血再灌注损伤
Kangyu Wang,Changhong Xu,Hao Wang et al.
Kangyu Wang et al.
Background: Renal ischemia-reperfusion injury (RIRI) is a major cause of perioperative acute kidney injury and a driver of chronic kidney disease, in which mitochondrial dysfunction and inflammatory activation create a vi...
TMX1 promotes the progression of hepatocellular carcinoma by inhibiting ferroptosis via stabilizing FABP5 [0.03%]
TMX1通过稳定FABP5抑制铁死亡从而促进肝癌进展
Xiaofei Duan,Zhipin Yan,Jie Gao et al.
Xiaofei Duan et al.
Thioredoxin-related transmembrane protein 1 (TMX1), a member of the thioredoxin-like family, upregulated in certain human malignancies and is implicated in tumorigenesis and progression. However, its biological functions in hepatocellular c...
Selenoprotein P drives glioma malignancy via LRP8-dependent activation of Wnt/β-catenin signaling [0.03%]
硒蛋白P通过LRP8依赖的Wnt/β-连环蛋白信号激活驱动胶质瘤恶性肿瘤进展
Xiaoke Wu,Yao Zhang,Guang Rong et al.
Xiaoke Wu et al.
Glioma is a highly aggressive central nervous system malignancy with poor prognosis and limited therapeutic options. Selenoprotein P (SeP) plays key roles in the nervous system, but its function in glioma remains unclear. Analysis of TCGA a...