Mechanisms of Qing-Shen-Du formula in treating diabetic kidney disease: Integrating network pharmacology, molecular docking, molecular dynamics, transcriptomics, and experimental validation [0.03%]
清肾毒方治疗糖尿病肾脏疾病的机制研究：网络药理学、分子对接、分子动力学、转录组学及实验验证整合式研究
Jie Zhao,Hua Su,Fang Lan et al.
Jie Zhao et al.
Diabetic kidney disease (DKD) represents the major contributor to end-stage renal disease globally, but no curative therapies are currently available. Qing-Shen-Du formula (QSDF), a Traditional Chinese Medicine formula, confers notable prot...
PEth in review: Phosphatidylethanol discovery and LC-MS/MS analysis [0.03%]
PEth研究进展：磷脂乙醇的发现及LC-MS/MS分析方法
Grace R Williams,Justin L Poklis,Carrol Nanco et al.
Grace R Williams et al.
The objective of this manuscript is to provide contextual information about the clinical ethanol biomarker phosphatidylethanol and evaluate contemporary analysis methods, mainly analysis by LC-MS/MS. The first part of the manuscript include...
Validated UPLC-MS/MS quantification and intracellular PK-PD Modeling of periplocin-related cardiac glycosides in H/R-injured H9c2 cells [0.03%]
用于H/R损伤的H9c2细胞中人参皂苷类强心苷定量鉴定及细胞内PK-PD建模的UPLC-MS/MS方法学研究
Peng Zhao,Fanjiao Zuo,Caixia Li et al.
Peng Zhao et al.
Reliable intracellular quantification is essential for characterizing the target-site disposition and exposure-response relationships of bioactive natural products. In this study, an ultra-performance liquid chromatography-tandem mass spect...
Pinggan Yishen formula alleviates cardiovascular remodeling in SHR while modulating vascular MLCK and cardiac Tsc22D4 [0.03%]
补心益牌方通过调节血管肌球蛋白轻链激酶和心脏Tsc22D4减轻SHR心血管重构
Junjie Sun,Huihui Wang,Xinfang Xia et al.
Junjie Sun et al.
Ping-Gan-Yi-Shen formula (PGYS) is mainly used for patients with severe hypertension accompanied by dizziness and headache, and has shown good clinical efficacy. In this study, liquid chromatography-tandem mass spectrometry (LC-MS/MS), targ...
Unravelling bioanalytical innovations, degradation processes, and impurity landscapes of VEGFR inhibitors [0.03%]
血管生成抑制剂的生物分析创新、降解过程及杂质图谱解析
Pratiksha Misal,Chaitali Thakare,Atul Shirkhedkar et al.
Pratiksha Misal et al.
From pre-formulation studies to clinical trials, VEGFR-targeted small-molecule tyrosine kinase inhibitors (TKIs) require rigorous analytical standards. Bioanalysis, stability-indicating studies, and impurity profiling are used to examine ch...
A versatile reversed-phase liquid chromatography charged aerosol detection method for streamlined monitoring of QS-21 content and stability in liposomal adjuvant formulations [0.03%]
一种通用的反相液相色谱电荷气溶胶检测方法，用于简化的脂质体佐剂配方中QS-21含量和稳定性的监测
Caleb Kinsey,Rodell C Barrientos,Mayank Bhavsar et al.
Caleb Kinsey et al.
Identifying and quantifying an active adjuvant along with its degradants in drug formulations is essential for ensuring the safety and efficacy of the drug product. QS-21 is a potent adjuvant that is being evaluated in several clinical tria...
Improved comprehensive profiling of fecal bile acids through chemical derivatization combined with HPLC-MS/MS analysis [0.03%]
基于化学衍生化与HPLC-MS/MS联用技术的粪便胆汁酸组学分析优化方法研究
Yanan Wang,Yongbo Chen,Qixian Ling et al.
Yanan Wang et al.
Bile acids (BAs) facilitate the digestion and absorption of fats and influence lipid and glucose homeostasis, making them potential therapeutic targets for obesity and related metabolic disorders. The liver and intestinal microbiota modify ...
Extraction and UPLC-MS-MS identification of active ingredients of Henophyton deserti: Antibacterial, antifungal and in silico studies [0.03%]
Henophyton deserti活性成分的提取及UPLC-MS-MS鉴定：抗菌、抗真菌及计算机模拟研究
Oussama Boukhalfa,Khaled Sekkoum,Samia Hadj Rabia et al.
Oussama Boukhalfa et al.
The plant extracts are gaining importance as natural antibiotic agents in this time of increasing antibiotic resistance. Therefore, the active ingredients of the Henophyton deserti plant were extracted and identified by UPLC-MS-MS analysis....
Direct background subtraction LC-MS/MS assay for human plasma progesterone: Full validation and comparative application [0.03%]
人血浆孕酮的直接背景扣除法LC-MS/MS测定：完整验证及应用比较
Yichao Xu,Xinhua Hu,Pengfei Zhao et al.
Yichao Xu et al.
Objective: To develop and validate a liquid chromatography-tandem mass spectrometry method based on direct background subtraction for the quantification of endogenous progesterone in human plasma. ...
Development and validation of an LC-MS/MS method for the quantification of the KRASG12C inhibitor divarasib [0.03%]
LC-MS/MS定量方法开发与验证用于KRASG12C抑制剂Divarasib的发展与验证
Jamie Rijmers,Viët Bui,Maria C Lebre et al.
Jamie Rijmers et al.
Divarasib is a newly developed covalent KRASG12C inhibitor, currently under clinical investigation in a phase 3 trial in patients with non-small cell lung cancer (NSCLC). At the moment, very limited pharmacokinetic data are publicly known. ...