Courtney A Miller,Alfredo Quinones-Hinojosa,Steven S Rosenfeld
Courtney A Miller
Non-muscle myosin II (NMII) comprises a family of cytoplasmic motors with important roles in both normal biology and disease. In this forum article we describe recent developments that validate NMII as a therapeutic target, and we illustrat...
Jing Liu,Xiaozhen Tan,Xia Fang et al.
Jing Liu et al.
Diabetic nephropathy (DN), a leading cause of chronic kidney disease and end-stage renal disease, remains a major clinical challenge. Current therapeutic strategies primarily delay rather than prevent disease progression, highlighting the u...
Targeting Tregs in T1DM: bridging heterogeneity, mechanisms, and clinical progress [0.03%]
T1DM中靶向调节性T细胞：异质性、机制和临床进展之间的关系
Yutong Li,Eyad Elkord
Yutong Li
Regulatory T cells (Tregs) play a pivotal role in maintaining immune tolerance and sustaining immunological homeostasis. Emerging evidence indicates that Treg characteristics and functional alterations can significantly contribute to the pa...
Alexander Hoffmann,Philipp Grubwieser,Dirk Bumann et al.
Alexander Hoffmann et al.
The escalating threat of antimicrobial resistance demands innovative therapeutic strategies beyond classical targets. Recent insights into the mechanisms of bacterial iron acquisition - ranging from siderophores and heme uptake to ferrous i...
Multitargeting neuroimmune pathways: novel candidates for chronic pain relief [0.03%]
多靶点神经免疫途径：慢性疼痛缓解的新型候选药物
María Florencia Coronel,Marcelo José Villar,Pablo Rodolfo Brumovsky
María Florencia Coronel
Chronic pain remains inadequately managed, partly because of insufficient consideration of neuroimmune interactions in therapeutic design and a continued reliance on single-target strategies ill-suited to its complexity. Multitarget-directe...
The ABCs of psychedelics: a preclinical roadmap for drug discovery [0.03%]
从药物发现的角度看迷幻药：临床前研究路线图ABC指南
Alex C Kwan,John R Mantsch,John D McCorvy
Alex C Kwan
There is growing interest in developing psychedelic-inspired drugs for treating psychiatric disorders. However, identifying next-generation psychedelic analogs with ideal receptor selectivity and true therapeutic efficacy remains a major ch...
Wenqiang Liu,Xuekun Wu,Wenshu Zeng et al.
Wenqiang Liu et al.
Cardiac fibrosis is a hallmark of cardiovascular and systemic diseases that arises in diverse pathological contexts such as inflammation, metabolic stress, and mechanical overload. Despite its clinical relevance, no FDA-approved therapies d...
Jonathan C M Wan,Ahmed Eldarwi,Luis A Diaz Jr
Jonathan C M Wan
Historically, the clinical application of cell-free RNA (cfRNA) liquid biopsies has been limited by background noise. In a recent study, Nesselbush et al. developed a method for denoising cfRNA analysis, resulting in RARE-seq, a versatile l...
Bingzhi Li,Xiaolong Zheng,Xing Zhang et al.
Bingzhi Li et al.
GlycoRNAs are glycosylated noncoding RNAs displayed on the cell surface. Emerging studies reveal their roles in intercellular communication and their dysregulation in inflammation and cancer, highlighting therapeutic potential. This review ...
Beyond lipids: fenofibrate in diabetic retinopathy and nephropathy [0.03%]
血脂之外：非诺贝特在糖尿病视网膜病变和肾病中的应用
Mengying Liu,Seok Ting Lim,Weihua Song et al.
Mengying Liu et al.
Diabetic retinopathy (DR) and nephropathy (DN) are leading microvascular complications of diabetes, yet current therapies remain inadequate. Fenofibrate, a peroxisome proliferator-activated receptor (PPAR)-α agonist approved for dyslipidem...