Robert B Cameron,Nia G Hammond,Brandon Faubert
Robert B Cameron
Cancer cells alter metabolic programs to support uncontrolled growth and proliferation. A new study from Scott and colleagues directly examined tumor metabolism in glioblastoma patients and discovered increased import of the amino acid seri...
Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology [0.03%]
从肿瘤学和神经病学角度看SUMO修饰底物多泛素化的再编程的机会与挑战
Gina Gotthardt,Jan Keiten-Schmitz,Stefan Müller
Gina Gotthardt
Drugs that reprogram the cellular ubiquitin-proteasome system for removal of disease-causing proteins hold great promise as a new type of pharmacology. Small ubiquitin-related modifier (SUMO)-targeted ubiquitin ligases (StUbLs) are E3 ubiqu...
Christopher H George,Simon T Bate,S Clare Stanford et al.
Christopher H George et al.
A central tenet of research articles is that they should accurately describe the experiments performed. Yet important aspects of experimental design and methods are sometimes omitted, precluding proper interpretation and follow-on studies. ...
Habib Baghirov
Habib Baghirov
Transcytosis across the blood-brain barrier (BBB) enables systemically administered large therapeutics to reach the brain parenchyma, but their fate in the parenchyma ultimately governs their therapeutic effect. Recent studies show that bra...
Jiangqi Luo,Yue Wang,Chengzhong Yu et al.
Jiangqi Luo et al.
Adjuvants are substances used in vaccines to boost antigen-specific immune responses. Aluminum salts (alum) were the first adjuvant approved for human use. Unfortunately, they mainly induce antibody responses and are ineffective at elicitin...
Bassem A Almalki
Bassem A Almalki
Metabolic derangements, particularly obesity and post-transplant diabetes mellitus, remain major challenges in solid organ transplantation, contributing to graft dysfunction and increased morbidity. Glucagon-like peptide-1 receptor agonists...
Multivalent decoy receptor therapeutics to combat viral pandemics and evolution [0.03%]
用于对抗病毒大流行和进化的多价诱饵受体疗法
Alex Odoom,Eugene M Obeng,Christian K O Dzuvor
Alex Odoom
Viruses are likely to cause future pandemics due to their inherent ability to evolve and spread rapidly, with limited treatment options. Engineered multivalent decoy receptors (EMDRs) offer a broad-spectrum alternative treatment option. We ...
Sonia Sonda,Diana Pendin,Stefano Comai et al.
Sonia Sonda et al.
Psilocybin, a serotonergic psychedelic, is gaining attention for its rapid and sustained therapeutic effects in depression and other hard-to-treat neuropsychiatric conditions, potentially through its capacity to enhance neuronal plasticity....
Viral evasion of cGAS-STING pathway: opportunities for intervention [0.03%]
病毒逃逸cGAS-STING信号通路：干预机会与挑战
Xiao-Fang Yu,Songdi Wang,Runxin Ye et al.
Xiao-Fang Yu et al.
The cyclic GMP-AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING) pathway, a crucial component of host innate immunity, detects aberrant DNA during viral infection. It is well established that cGAS-STING signaling activa...
The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics [0.03%]
B7-H3（CD276）通路：新兴生物学与临床治疗学
Devin T Corrigan,Ankit Tanwar,Meirong Du et al.
Devin T Corrigan et al.
B7-H3 (CD276), an orphan member of the B7 family, is an immune checkpoint ligand and a tumor-associated antigen. Recent developments regarding dimerization, glycosylation, expression regulation, and effects on cell metabolism are emerging, ...