Junsha An,Limei Zhang,Yue Duan et al.
Junsha An et al.
Cancer cells exhibit unique metabolic reprogramming characterized by a significant increase in intracellular sodium ion levels. Sodium influences cancer cell metabolism, immune function, and drug resistance, and can trigger a unique cell de...
Jerry C Madukwe
Jerry C Madukwe
Sirtuins in Alzheimer's disease: mechanistic insights and therapeutic opportunities [0.03%]
沉默素与阿尔茨海默病：机制研究及治疗应用的机遇
Ning Bai,Shuhui Liu,Jiayi Wei et al.
Ning Bai et al.
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by progressive cognitive decline and complex neuropathology. Its main features include amyloid-β (Aβ) plaques, tau neurofibrillary tangles (NFTs), and ne...
Sean Ekins,Barbara S Slusher
Sean Ekins
Proposed budget cuts to the National Institutes of Health (NIH) by the current administration pose significant risk to academic and small biopharma drug discovery in the USA. Yet even in this challenging climate, there are viable strategies...
Yan-Ruide Li,Lili Yang
Yan-Ruide Li
Chimeric antigen receptor (CAR)-based therapies are emerging for autoimmune diseases (ADs). Early-phase clinical studies in systemic lupus erythematosus (SLE) show encouraging results using autologous, allogeneic, and in vivo CAR T-cell (CA...
Epigenetic modifications in retinal ganglion cell survival and axonal regeneration [0.03%]
视网膜神经节细胞存活和轴突再生的表观遗传调控
Ming Feng,Kexin Tan,Shuo Wu et al.
Ming Feng et al.
The optic nerve, a component of the central nervous system (CNS), comprises axons from retinal ganglion cells (RGCs) that exhibit limited regenerative capacity following injury. Recent advances have substantially deepened our understanding ...
Ana M B Amorim,Urszula Orzeł,Ana B Caniceiro et al.
Ana M B Amorim et al.
Rare diseases (RDs) affect more than 400 million people worldwide, yet most patients remain undiagnosed or untreated due to delayed diagnosis and limited therapies. Artificial Intelligence (AI) offers powerful tools to address these unmet n...
Andrew H Reiter,Aaron Fehr,Roberta Florea et al.
Andrew H Reiter et al.
Membrane proteins are essential for cellular physiology and the target of half of all FDA-approved drugs. However, their hydrophobicity and low abundance make large-scale expression and purification difficult, posing a challenge for drug di...
Marzia Fois,Lucija Peterlin Mašič,Tihomir Tomašič
Marzia Fois
Small-conductance calcium-activated potassium (SK) channels regulate excitability and calcium signaling in neurons, cardiomyocytes, and endothelial cells. Their dysfunction contributes to a broad spectrum of disorders, including neurodegene...
Canhui Cao
Canhui Cao
Small cell lung cancer (SCLC) progression relies on neuronal activity, yet the mechanisms remain unclear. Two recent studies by Savchuk et al. and Sakthivelu et al. reveal that SCLC co-opts vagal and sympathetic inputs and forms glutamaterg...