Zaahida Sheik Ismail,Taoqian Zhao,Steven H Liang et al.
Zaahida Sheik Ismail et al.
Jerry C Madukwe
Jerry C Madukwe
Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities [0.03%]
针对肿瘤离子通道失调的治疗：新兴的治疗机会
Weici Laurence Liu,Xiaowen Xie,Hanqing Chen et al.
Weici Laurence Liu et al.
Tumor cells often display distinct electrophysiological properties compared with normal cells, including more frequent ion channel dysregulation and pronounced membrane potential depolarization. These abnormalities give rise to irregular el...
Joshua D Josef,Ruminder P Kaur,Sanjoy K Bhattacharya et al.
Joshua D Josef et al.
Cataract and presbyopia are the leading causes of age-related vision impairment worldwide, yet non-surgical management options remain limited. Age-related changes in the lipid composition of the crystalline lens have been implicated in thei...
Treating periodontal disease: from antimicrobials to immunomodulation [0.03%]
从使用抗菌药物到调节免疫功能的牙周病治疗方法的发展
Julie A Kobyra,Mostafa Shehabeldin,Steven R Little et al.
Julie A Kobyra et al.
Dysregulated host immune responses are characteristic of a variety of inflammatory-mediated diseases. As such, novel immune-modulating therapies have been developed for the treatment of these inflammatory conditions. One condition that has ...
Renming Fan,Bingjie Zhang,Gaofei Wei
Renming Fan
The bioenergetic crisis in cancer cachexia arises from early mitochondrial dysfunction that precipitates muscle wasting. In a recent study, Angelino et al. found that tumor-derived signals suppress the cAMP-protein kinase A (PKA)-CREB1 axis...
Abhinav Purohit,Ishaan Joshi,Pratik S Bhojnagarwala et al.
Abhinav Purohit et al.
Siglecs are a family of sialic acid-binding immunoglobulin-like lectins that regulate immune signaling and maintain homeostasis through glycan recognition. Despite their central role in immune modulation, their therapeutic potential remains...
Nerandomilast as the first PDE4B-selective therapy in idiopathic pulmonary fibrosis [0.03%]
Nerdomilast作为首个PDE4B特异性疗法在特发性肺纤维化中的应用研究
Md Ibrahim,Gary A Piazza,Fakhrul Ahsan
Md Ibrahim
David A Bader,Binita Chakraborty,Donald P McDonnell et al.
David A Bader et al.
Men experience higher cancer incidence and mortality than women, and accumulating evidence implicates androgen receptor (AR) signaling as a key biological driver of these sex-based disparities. AR signaling can suppress adaptive anticancer ...
Princy Shrivastav,Rohit Singh,Andrew J Wiemer
Princy Shrivastav
Molecular glues (MGs) modulate protein interactions to inhibit, activate, or degrade targets. Classical MGs like thalidomide, cyclosporin, and fusicoccin were discovered serendipitously; a key challenge is to develop rational design approac...