Morgan M Barnes,Taoqian Zhao,Wanlin Ye et al.
Morgan M Barnes et al.
β-Arrestins and disease-linked variants: opportunities for targeted modulation [0.03%]
β- arrestin与疾病相关变异：靶向调节的机会
Simon Hasinger,Andreas Fraunhofer,Julius Hermes et al.
Simon Hasinger et al.
G protein-coupled receptors orchestrate numerous physiological processes and represent the largest class of drug targets, yet their intracellular regulators, the β-arrestins, remain largely underexplored. Despite their crucial roles in rec...
Attruby for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM) [0.03%]
ATTR治疗转甲状腺素蛋白淀粉样变性心肌病(ATTR-CM)
Taoqian Zhao,Sharmila Dorbala,Steven H Liang
Taoqian Zhao
Ruth Nussinov,Clil Regev,Hyunbum Jang
Ruth Nussinov
Proteins involved in signaling networks, such as Ras, mammalian target of rapamycin (mTOR), and epidermal growth factor receptor (EGFR), exist as dynamic conformational ensembles in biomolecular condensates. These ensembles play a crucial r...
Wanlin Ye,Xin Li,Jocelyn Chandra et al.
Wanlin Ye et al.
Metabolism modulation has emerged as a promising frontier in precision oncology. Nonetheless, the primary gap is the inability to precisely target the unique metabolic vulnerabilities of different cell types in vivo, which has limited clini...
Morgan Barnes,Renuka Raman,Sean Ekins
Morgan Barnes
The palmitoylation/depalmitoylation cycle regulates protein localization, function, and stability, playing essential roles in signal transduction, membrane trafficking, and neuronal activity. Understanding the enzymes involved may reveal no...
Evolving paradigms in targeting FLT3 for acute myeloid leukemia therapy [0.03%]
急性髓系白血病治疗中靶向FLT3的新理念
Rajan Thapa,Jesus Shrestha,Keshav Raj Paudel
Rajan Thapa
FLT3 mutations drive acute myeloid leukemia (AML) progression through aberrant signaling, making FLT3 inhibition a key therapeutic strategy. Current inhibitors show efficacy, yet resistance and toxicity remain challenges. Emerging approache...
Targeted alpha therapy (r)evolution: emerging nuclides for clinical applications [0.03%]
靶向α治疗的革命：临床应用中的新兴核素
Nadia B Pedersen,Natan J W Straathof,Filipe Elvas et al.
Nadia B Pedersen et al.
Targeted alpha therapy (TAT) delivers localized, high linear energy transfer (LET) radiation that induces irreparable DNA damage, particularly double-strand breaks, leading to selective tumor cell death. Alpha emitters are gaining interest ...
Jie Bi,Lingxiao Jiang,Jiaqi Zhao et al.
Jie Bi et al.
Precision immunotherapy leverages the immune system to selectively eliminate abnormal cells while sparing healthy cells. Targeting specific peptide-human leukocyte antigen (pHLA) complexes, derived from cancer, autoimmune, and infectious di...
Qingyuan Xu,Keke Huang,Yibing Shi et al.
Qingyuan Xu et al.
G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are involved in numerous physiological and pathological processes. Therapeutic antibodies targeting GPCRs, including monoclonal antibodies (mAbs), si...