Min Zhang,Chengli Liu,Aifang Cheng et al.
Min Zhang et al.
Therapeutic hypothermia is robustly neuroprotective in models but slow to initiate and hard to sustain clinically. This gap motivates pharmacological strategies that capture 'cold' protection at normothermia. Recent advances across the cold...
Wenyan Qin,Huan Sheng,Xiaoyun Hu et al.
Wenyan Qin et al.
Cuproptosis is a mitochondria- and copper-dependent regulated form of cell death that has attracted growing interest as a therapeutic strategy in oncology. Its core mechanism involves the aggregation of lipoylated proteins in the tricarboxy...
Targeting the senescence-autophagy axis for idiopathic pulmonary fibrosis therapy [0.03%]
针对特发性肺纤维化治疗靶向衰老自噬轴
Jeong-Yeon Min,Eun Choi,Young Jo Yoo et al.
Jeong-Yeon Min et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive, age-associated interstitial lung disease with limited therapeutic options. Current antifibrotics modestly slow the decline but fail to halt or reverse fibrosis. Emerging evidence implica...
Zycubo (copper histidinate), the first treatment for pediatric Menkes disease [0.03%]
铜组氨盐治疗小儿门克斯病获突破性疗法认定
Md Aktaruzzaman,Zihan Wang,Ying Yu et al.
Md Aktaruzzaman et al.
Copper histidinate (marketed as ZYCUVO®, formerly known as CUTX-101) is a copper replacement product indicated for the treatment of Menkes disease in pediatric patients. The chemical name is copper, (L-histidinato-κN,κN3,κO)(L-histidina...
Rafael André da Silva,Shama Parween,Anna Howell et al.
Rafael André da Silva et al.
Once known only as immune sentinels, formyl peptide receptors (FPRs) have emerged as paradoxical regulators of ocular health, capable of driving injury or repair in a ligand-dependent manner. We discuss FPR signaling in diabetic retinopathy...
Complement dysregulation in multiple sclerosis: emerging mechanisms and translational therapeutic opportunities [0.03%]
补体在多发性硬化中的失调：新兴机制和转化治疗机遇
Nemat Khan,Zikra M Zakriya,Pamela McCombe et al.
Nemat Khan et al.
The complement system is a conserved network of plasma and membrane-associated proteins that supports immune defense and tissue homeostasis. In multiple sclerosis (MS), persistent complement activation contributes to neuroinflammation, demy...
Targeting metabolism to combat anticancer and antibacterial drug resistance [0.03%]
靶向代谢以对抗抗癌和抗菌药物耐药性
Carolina H Chung,Rupa Bhowmick,Annie J Badenoch et al.
Carolina H Chung et al.
Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutions. Recent research suggests that bacteria and cancer cells reprogram their metabolism and manipulate their external metabolic environment t...
Menghua Wang,Takudzwa Chiwoneso,Zimeng Luo et al.
Menghua Wang et al.
Nuclear liquid-liquid phase separation (LLPS) is now recognized as a fundamental mechanism that organizes transcription and DNA repair machinery into dynamic, membraneless condensates essential for genome integrity and gene regulation. Dysr...
Dynamics and heterogeneity of the neurovascular unit in ischemic stroke [0.03%]
缺血性卒中后神经血管单元的动态变化及异质性研究
Peng Teng,Ying-Ying Wang,Chen-Yun Ding et al.
Peng Teng et al.
The neurovascular unit (NVU) is a multicellular system functioning to maintain healthy brain homeostasis and regulate the exchange of essential elements between the blood and the brain. Recent studies have shown that, in response to ischemi...
Shiming Li,Yurui Yang,Haibo Qiu et al.
Shiming Li et al.
Macrophages play pivotal roles in regulating immune responses during inflammation and cancer. Recent evidence indicates that macrophages are dynamic cells capable of switching between different functional states in response to stimuli from ...