Junyu Wang,Fangyuan Jing,Yinuo Zhao et al.
Junyu Wang et al.
Piezo1, a mechanosensitive ion channel protein, is a highly promising target for drug development. We systematically review the latest advances in its structural features, signal transduction mechanisms, and functional roles in various path...
Bingjun Ha,Xuetao Cao
Bingjun Ha
The constitutive presence of immune cells within brain parenchyma under homeostatic conditions is debated. Recent findings by Yoshida et al. have shown that the subfornical organ harbors gut- and adipose-derived T cells that secrete IFN-γ ...
Structure-function-guided drug development efforts to target lncRNAs [0.03%]
结构功能导向的靶向长链非编码RNA(LncRNA)药物开发进展
Hollie Watmuff,Amy Crawford,Bryan Eusse et al.
Hollie Watmuff et al.
Long noncoding RNAs (lncRNAs) play a pivotal role in regulating cellular processes, and their dysregulation has been linked to the progression of disease. Understanding the structural characteristics, protein interactions, and expression dy...
Swapneel J Patel,Zhijian J Chen
Swapneel J Patel
Identification of therapeutic vulnerabilities in cancer remains a high priority for cancer research. A recent CRISPR/Cas9 screen identified that VDAC2 deletion in tumors enhanced their sensitivity to interferon-γ (IFNγ) through the releas...
M H Wang,J Liu,S L Li et al.
M H Wang et al.
Amphiregulin (AREG), a ligand of the epidermal growth factor receptor (EGFR), plays critical roles in immune homeostasis, cell proliferation, and tissue repair. Recent preclinical studies have shown that AREG is markedly upregulated in vari...
Kostas A Papavassiliou,Alice G Vassiliou,Athanasios G Papavassiliou
Kostas A Papavassiliou
KRASG12V-driven cancers remain therapeutically elusive. Recently, Stanland and colleagues developed EFTX-G12V, a GE11-conjugated small interfering RNA (siRNA) that selectively silences KRASG12V and achieves tumor regression by inhibiting on...
Yifei Dong,V Wee Yong
Yifei Dong
Neuroinflammation and neurodegeneration are key pathological features of chronic neurological diseases. In a recent study, Woo and colleagues highlight that interferon (IFN)-γ signaling promotes an immunoproteosome-mediated shift of metabo...
Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance [0.03%]
靶向LKB1/STK11突变型癌症：不同的代谢、微环境和治疗抗性
Allegra C Minor,Evan Couser,Lillian J Eichner
Allegra C Minor
Despite the development of new classes of therapeutics in oncology, patients with tumors harboring mutations in the tumor suppressor gene STK11/LKB1 continue to exhibit poor clinical response and therapeutic resistance. Recent advances in t...
TREM2 and LAG-3 in cancer and Alzheimer's disease immunotherapy [0.03%]
癌症与阿尔茨海默病免疫疗法中的TREM2和LAG-3作用机制研究进展
Shaoren Yuan,Natalie S Fuchs,Somaya A Abdel-Rahman et al.
Shaoren Yuan et al.
Alzheimer's disease (AD) and cancer are immune-mediated disorders characterized by chronic neuroinflammation and immune evasion, respectively. Recent studies implicate two key immune regulators in both diseases: LAG-3, an adaptive immune ch...
Frank Buttgereit,Christian Elling,Florian Jakob
Frank Buttgereit
Synthetic glucocorticoids (GCs) are effective anti-inflammatory drugs but cause serious adverse effects (AEs). Initially, anti-inflammatory efficacy and AEs were ascribed to GC receptor (GR)-mediated gene transrepression and transactivation...