Metabolomic analysis of macromycetes from French Guiana reveals chemodiversity in Xylariales order [0.03%]
法属圭亚那大型真菌代谢组分析揭示Xylariales目中的化学多样性
Jonathan Sorres,Juliette Segret,Elsa Van-Elsande et al.
Jonathan Sorres et al.
An original approach was undertaken to explore the metabolomic variability of macroscopic fungi collected in French Guiana. Extracts from 160 specimens, representing 13 fungal orders, were analyzed using liquid chromatography coupled with t...
More than just flavour and fragrance - the chemistry and pharmacological potential of Anethole [0.03%]
不仅仅是风味和香气——茴香醇的化学和药理潜力
Ruchi Badoni Semwal,Deepak Kumar Semwal,Ankit Kumar et al.
Ruchi Badoni Semwal et al.
Anethole, a naturally-occurring aromatic phenylpropene compound, is commonly present in the essential oils derived from botanically diverse plants, including anise, star anise, fennel and basil. It is highly regarded for its therapeutic pro...
γ-lactam and γ-lactone-containing sesterterpenoids from Colquhounia coccinea var. mollis with immunosuppressive activity [0.03%]
含γ-内酰胺和γ-内酯结构的五环塞瑟萜类化合物及其免疫抑制活性研究
Shu-Xi Jing,Chun-Huan Li,Yan-Chun Liu et al.
Shu-Xi Jing et al.
Ten previously undescribed sesterterpenoids (1-10), characterized by α,β-unsaturated-γ-lactam and γ-lactone motifs, were isolated from Colquhounia coccinea var. mollis and their structures were elucidated via spectroscopic analyses (1D/...
Integrated multi-omics demonstrates DNA demethylation-driven activation of the RgMYB2-RgG10H4 axis enhancing iridoid glycoside biosynthesis in Rehmannia glutinosa [0.03%]
整合多组学证明DNA去甲基化驱动的RgMYB2-RgG10H4轴活化可增强玄参中皂苷生物合成
Tianyu Dong,Yajie Du,Tingting Huang et al.
Tianyu Dong et al.
Rehmannia glutinosa roots produce a group of lipophilic bioactive components known as iridoid glycosides. However, the molecular mechanisms by which DNA methylation regulates the biosynthesis of iridoid glycosides in R. glutinosa remain unk...
Qianqian Zhang,Ping Zhang,Yijin Wu et al.
Qianqian Zhang et al.
Ohwia caudata, a significant traditional Chinese medicine, exhibits anti-inflammatory properties and is clinically used to treat dysentery, gastroenteritis, and other inflammatory conditions. However, the bioactive constituents responsible ...
Phragmalin-type limonoid orthoesters from the twigs and leaves of Khaya ivorensis and their cytotoxic activities [0.03%]
吉贝树枝叶中的香豆素类柠檬苦素邻酯化合物及其体外细胞毒性作用研究
Zong-Yi Zhang,Jia-Nan Wang,Peng Sun et al.
Zong-Yi Zhang et al.
Nine previously unreported phragmalin-type limonoid orthoesters, named ivorenoids G-O (1-9), together with seventeen known analogues (10-26) were isolated from the twigs and leaves of Khaya ivorensis. Their structures, including absolute co...
Cytotoxic tetralone homology dimers from mangrove-associated fungus Cytospora heveae NSHSJ-2 [0.03%]
来源于互花米草内生真菌Cytospora heveae NSHSJ-2的四酮类同源二聚体化合物及其活性
Yufeng Liu,Tao Chen,Ge Zou et al.
Yufeng Liu et al.
Seven previously undescribed metabolites, including four cladosporols, named cytosporols A-C (1-3), cladosporol L (4), and three polyketides, photinide G (5), cytorhizophin K (7), pestalotiotone C (9), were isolated from the cultures of the...
NMR-guided isolation of alkaloids from Nigella glandulifera seeds and their bioactivities [0.03%]
基于核磁共振指导的Nigella glandulifera种子中生物碱类成分的分离及其活性研究
Tuernisan Tudi,Ruxianguli Rouzimaimaiti,Deng Zang et al.
Tuernisan Tudi et al.
NMR-guided investigation of Nigella glandulifera Freyn et Sint seeds led to the isolation and characterization of 11 previously undescribed alkaloids, designated nigelladine D-N (1-11). These include three skeletons: (+)/(-)-nigelladine D (...
Functional Characterization and Directed Evolution of Cicer arietinum Glutathione Transferases for Enhanced Hydroperoxidase Activity and Ligandin Function [0.03%]
牻牛儿牻牛儿素转移酶的功能表征及其功能和配体结合功能的定向进化
Anni Kontouri,Nikolaos Georgakis,Anastassios C Papageorgiou et al.
Anni Kontouri et al.
Tau class glutathione transferases (GSTUs) play essential roles in plant defense by facilitating the nucleophilic attack of glutathione (GSH) to a wide range of electrophilic xenobiotics. In addition to their conjugating activity, these enz...
Plant protoberberine alkaloids: structural diversity, biosynthesis, synthesis, biological activity, structure-activity relationships and clinical applications of berberine [0.03%]
植物原小檗碱生物碱：小檗碱的结构多样性、生物合成、合成、生物学活性、构效关系及临床应用
Weiqi Jiang,Wen Zhang,Chenxin Jing et al.
Weiqi Jiang et al.
Protoberberine alkaloids are a class of organic heterocyclic compounds categorized within the isoquinoline alkaloids, exhibiting significant therapeutic potential due to their potent biological activities. With advancements natural product ...