Biopharmaceutical evaluation of benznidazole-loaded microparticles: In vitro and in vivo studies [0.03%]
苯硝唑载药微粒的生物制药评价：体外和体内研究
Katia P Seremeta,Giselle R Bedogni,Miguel Ángel Allo et al.
Katia P Seremeta et al.
Benznidazole, one of only two approved treatments for Chagas disease, exhibits poor water solubility (
Targeted inhibition of gastric adenocarcinoma by nano-curcumin liposomes: Insights from combined machine learning and experimental analyses into the mechanisms of cuproptosis and metabolic reprogramming [0.03%]
纳米姜黄素脂质体靶向抑制胃腺癌：结合机器学习和实验分析探讨铜死亡和代谢重编程的机制
Jun-Feng Cao,Kuan Hang,Chunlu Tan et al.
Jun-Feng Cao et al.
Purpose: Gastric adenocarcinoma is a highly aggressive malignancy characterized by a complex tumor microenvironment. Nano-curcumin liposomes hold great potential in inhibiting tumor growth and survival, as well as inducin...
Breath-activated nanomedicine: Ambrisentan-loaded chitosomes for pulmonary arterial hypertension [0.03%]
呼吸激活型纳米药物：阿米苯特南载脂壳聚糖颗粒治疗肺动脉高压
Moustafa S Ali,Mona Elhabak,Shaimaa S Ibrahim et al.
Moustafa S Ali et al.
Pulmonary arterial hypertension (PAH) is a life-threatening condition that detrimentally affects patient's quality of life. PAH is commonly managed by oral endothelin receptor antagonists like ambrisentan (AMB). However, due to untargeted d...
Choline chloride-malic acid Natural Deep Eutectic Solvent containing hydrophobic drugs: Insights into solubility and permeability behavior in digestive tract models [0.03%]
含疏水性药物的胆碱氯化物-苹果酸天然深共熔溶剂：消化道模型中的溶解度和渗透行为研究
Stefano Sangiorgi,Matilde Mancinelli,Serena Bertoni et al.
Stefano Sangiorgi et al.
This study evaluated the biopharmaceutical performance of six BCS Class II drugs with diverse physicochemical properties, formulated in a Natural Deep Eutectic Solvent (NaDES) composed of choline chloride and malic acid (1:1 M ratio). The s...
Successful prophylactic against Brucella melitensis using a vaccine candidate consisting of recombinant antigens OMP19 and L7/L12 loaded in a nanoliposomal adjuvant system in a mouse model [0.03%]
基于纳米脂质佐剂系统的OMP19和L7/L12重组抗原候选疫苗对鼠型地中海布鲁氏菌的预防作用研究得成功
Rahim Pirhajati,Mohsen Chiani,Mehri Habibi et al.
Rahim Pirhajati et al.
Brucellosis is a zoonotic disease caused by the genus Brucella. In the present study, a vaccine candidate composed of two recombinant antigens, OMP19 and L7/L12 of B. melitensis, encapsulated in a Nano Liposomal Adjuvant System (NLAS) was d...
Evaluation of emulsification behavior of two dual centrifuge types aided by CFD simulation [0.03%]
基于CFD模拟的两种双离心式发泡仪发泡行为评价研究
Nico Hellmund,Venkatesh Inguva,Denise Steiner
Nico Hellmund
Over the last two decades, dual centrifugation has proven to be a reliable technology for the preparation of lipid nanocarriers. Although it has been shown that the preparation of various lipid-based nanocarriers like liposomes, lipid nanos...
Theoretical calculation of the amounts of nucleotide deletion impurities in oligonucleotides [0.03%]
寡核苷酸中碱基删除杂质含量的理论计算
Yasunori Uchida,Tokuyuki Yoshida,Emi Saito et al.
Yasunori Uchida et al.
Therapeutic oligonucleotides are generally synthesized by solid-phase methods via repetitive nucleotide addition. Nucleotide deletion impurities, a class of impurities specific to oligonucleotide therapeutics, arise from incomplete nucleoti...
Comparative investigation of the transport and deposition of nebulized particles in pediatric mouth-throat airways with tonsil hypertrophy at different severity levels [0.03%]
不同扁桃体肥大水平下儿童口咽气道雾化颗粒传输及沉降的比较研究
Feilun Yang,Ruiping Ma,Yusheng Wang et al.
Feilun Yang et al.
Background: Pediatric allergic asthma necessitates efficient aerosol drug delivery through the mouth-throat (MT) airway. Tonsil hypertrophy (TH), a common comorbidity, causes oropharyngeal obstruction, potentially comprom...
Chalcogen-bond engineered redox-responsive nano-prodrugs for anticancer therapy [0.03%]
用于癌症治疗的硫族元素键工程型还原响应纳米前药
Guobing Feng,Guangfei Wei,Jialei Luo et al.
Guobing Feng et al.
The distinct redox imbalance in malignant cells, characterized by elevated reactive oxygen species and glutathione levels compared to normal tissues, establishes a therapeutic window for chemotherapeutic intervention through exploitation of...
NMN-primed exosomes derived from infrapatellar fat pad mesenchymal stem cells exert synergistic anti-inflammatory and cartilage-protective effects via MERTK pathway activation in knee osteoarthritis [0.03%]
富 NMN的髌下脂肪垫间充质干细胞衍生的外泌体通过激活MERTK通路在膝骨关节炎中发挥协同抗炎和保护软骨的作用
Ko-Ta Chen,Chi-Chang Huang,Vijesh Kumar Yadav et al.
Ko-Ta Chen et al.
Osteoarthritis (OA) is a chronic degenerative joint disease lacking effective disease-modifying therapies. This study evaluated the therapeutic potential of nicotinamide mononucleotide (NMN)-primed exosomes derived from infrapatellar fat pa...