Optimizing cinnamophilin delivery via SNEDDS for enhanced anti-melanogenic activity: A comprehensive evaluation of skin safety, permeability, and tyrosinase inhibition [0.03%]
通过SNEDDS优化递送香豆素菲林以增强抗黑化活性：皮肤安全性、透皮性和酪氨酸酶抑制性的综合评价
Yu-Chen Chen,Yih-Fung Chen,Hsin-Ya Yu et al.
Yu-Chen Chen et al.
Skin hyperpigmentation disorders, such as melasma and age spots, result from abnormal melanin overproduction and remain a significant dermatological concern. Tyrosinase, a key enzyme in melanogenesis, represents a critical target for depigm...
Shweta Singh,Ankur Vaidya,Navneet Verma
Shweta Singh
Skin cancer is increasing as a global health issue, with rising cases particularly in Caucasian populations. It is the most common cause of decreased quality of life worldwide. There are an estimated 1.5 million new cases each year. The con...
Endosomal escape and current obstacles in ionizable lipid nanoparticles mediated gene delivery: lessons from COVID-19 vaccines [0.03%]
基于离子脂质纳米颗粒的基因传递中溶酶体逃逸及目前存在的障碍：来自新冠疫苗的经验教训
Semmal Syed Meerasa,Aqeel Ahmad,Amer Ali Khan et al.
Semmal Syed Meerasa et al.
During last pandemic of COVID-19, two vaccines based on ionizable lipid nanoparticles (ILNP) were developed for COVID-19 prevention: Pfizer/BioNTech Vaccine (BNT162b2) and Moderna Vaccine (mRNA-1273). The observed efficacy of these two vacc...
Impact of magnesium aluminometasilicates on rheological and compaction properties of moisture-sensitive excipients [0.03%]
镁铝偏硅酸盐对易吸湿赋形剂的流变和压片性能的影响
Pavlína Komínová,Petr Zámostný,Jan Henrik Finke
Pavlína Komínová
Moisture is a critical external factor affecting the powder behaviour. This work focused on the effect of moisture on the rheological and compaction properties of two moisture-sensitive excipients, microcrystalline cellulose (MCC) and parti...
Artificial intelligence in the non-clinical laboratory: enhancing good laboratory and documentation practices [0.03%]
实验室人工智能：提高优质实验和文件记录规范的能力
Khadijah Zai,Anggoro Praja Mukti,Gabriella Sabeth Notty et al.
Khadijah Zai et al.
Non-clinical laboratories are under increasing regulatory pressure from agencies such as the FDA, EMA, and MHRA to ensure data integrity, traceability, and compliance with Good Laboratory Practice (GLP) and Good Documentation Practice (GDP)...
Roles and mechanisms of cuproptosis for reversing cancer therapeutic resistance [0.03%]
铜死亡在逆转癌症治疗耐药中的作用及机制研究
Tingting Wu,Shuman Wang,Yajing Liu et al.
Tingting Wu et al.
Cancer therapeutic resistance remains a major obstacle in clinical oncology, driven by multifaceted mechanisms including multidrug resistance, radioresistance, and immune evasion. Recent advances highlight cuproptosis, a novel copper-depend...
Nanofibrous smart wound dressing based on pH-responsive methacrylates copolymers: A review [0.03%]
基于pH响应型甲基丙烯酸酯共聚物的纳米纤维素智能伤口敷料的研究进展综述
Omid Ferdowsizadeh,Ali Poorkhalil,Mohamad Pezeshki-Modaress et al.
Omid Ferdowsizadeh et al.
Electrospinning is a versatile and eco-friendly method for producing ultra-fine nanofibers from various polymers. Among them, Eudragit® (a family of methacrylate copolymers) has gained prominence due to its pH-responsive solubility and pha...
Corrigendum to "Complementary approaches and advanced technologies in ameliorating rate of wound healing" [Int. J. Pharm. 682 (2025) 125910] [0.03%]
关于“改善伤口愈合速率的互补方法和先进技术”的勘误(国际药剂学杂志第六百八十二期125910篇)
Smitakshi Talukdar,Jharna Medhi,Pervej Alom Barbhuiya et al.
Smitakshi Talukdar et al.
Direct compression peptide tablets: insights into the importance of permeation enhancer processibility and peptide stability [0.03%]
透皮给药肽片剂：渗透增强型工艺处理和肽稳定性的启示
A Fagan,L M Bateman,M O&#x;Mahony et al.
A Fagan et al.
Much of the remarkable advancements in oral peptide delivery have been achieved through the use of chemical permeation enhancers, such as sodium caprate (C10) and salcaprozate sodium (SNAC). However, co-formulation of peptides with permeati...
Lyophilized Listeria monocytogenes vaccines for storage at non-ultra-low temperatures and cancer therapy [0.03%]
可在非超低温条件下保存的冻干恶疫梨头胞疫苗及其抗癌作用
Wyatt Paulishak,Larry Isenhower,Shadan Modaresahmadi et al.
Wyatt Paulishak et al.
Lyophilization is a common method of preparing bacteria for storage with lyoprotectant and buffer greatly impacting viability. Listeria monocytogenes (LM) is a Gram-positive intracellular bacterium being investigated preclinically and clini...