Enhancement of implant performance through synergistic drug delivery and bioactivity by nanotubular titanium with hydroxyapatite coating [0.03%]
通过羟基磷灰石涂层的纳米管钛实现药物协同释放和生物活性以提升植入物性能
Durgalakshmi Dhinasekaran,Jaya Priya Sivakumar,Ajay Rakkesh Rajendran
Durgalakshmi Dhinasekaran
Drug-eluting implants are considered to be the best alternative to traditional oral and intravenous administration of drugs. By the method of in vitro implantation of these implants, the major rejection during the initial implantation phase...
Statistical analysis of long-term physical stability testing of amorphous solid dispersions [0.03%]
长期物理稳定性的统计分析-有关无定形固体分散体的例子
Jingya Wu,Guy Van den Mooter
Jingya Wu
The underlying mechanisms governing amorphous solid dispersions (ASDs) stability are complex and influenced by multiple factors, making it a difficult problem to address comprehensively. The current study investigates how various factors af...
A new strategy for nanosuspension stabilizer screening based on computer-aided drug design and molecular self-assembly [0.03%]
基于计算机辅助药物设计和分子自组装的纳米悬浮稳定剂筛选新策略研究
Xiaoyang Zhang,Yao Zhang,Chaoliang Jia et al.
Xiaoyang Zhang et al.
The aim of this study is to elucidate the principles of surfactants and polymer stabilized nanosuspensions (NS) from a molecular perspective, and to develop a new strategy for screening NS stabilizers based on molecular self-assembly. Throu...
Application of multi-objective optimization algorithm to the preparation of polycaprolactone microsphere formulations [0.03%]
多目标优化算法在聚己内酯微球处方前研究中的应用
Yuchao Qiao,Shuhui Kang,Yijia Wu et al.
Yuchao Qiao et al.
Background: Polycaprolactone microspheres (PCL-MS) are widely used in tissue filling, where particle size and uniformity are crucial for improving filling and therapeutic effects. Efficient optimization methods are essent...
Novel non-invasive and reusable nanoparticle-based photothermal patch for antibacterial, antibiofilm, and anticancer activities via the synergistic effects of photothermal-induced photodynamic therapy [0.03%]
一种用于抗菌、抗生物膜和抗癌的新型非侵入性和可重复使用的纳米颗粒光热贴片，基于光热诱导的光动力疗法协同效应
Saichand Thakkellapati,Devyani Balasaheb Kandam,Tarun Kumar Sharma et al.
Saichand Thakkellapati et al.
Transdermal mediated therapeutic strategies are needed for treating delayed wound healing of bacterial infection mainly multi-drug resistant (MDR) strains and localised tumours like skin melanoma or oral carcinoma etc. In this work, we have...
Advances in alginate-based nanoformulations: Innovative and effective strategies for targeting and treating brain disorders [0.03%]
基于藻酸盐的纳米配方新进展：针对神经系统疾病治疗的有效策略
Ekta Rawat,Suman Sharma,Shweta Vyas et al.
Ekta Rawat et al.
Brain disorders, encompassing neurodegenerative conditions and intracranial neoplasms, present formidable obstacles in the realm of pharmacological delivery due to the existence of athe blood-brain barrier (BBB) and the restricted bioavaila...
Design and fabrication of pH-responsive charge-switchable PEG-CDM-PAMAM nanoassemblies to improve tumor therapy [0.03%]
设计和制造pH响应式电荷可切换的PEG-CDM-PAMAM纳米组装体以改善肿瘤治疗
Effat Nekoueifard,Fatemeh Radmanesh,Ebrahim Saeedian Moghadam et al.
Effat Nekoueifard et al.
Recent studies have extensively investigated the use of nanocarriers for targeted drug delivery to cancerous tumors, demonstrating promising outcomes. However, their clinical application reveals significant limitations that necessitate subs...
Static and in-situ synchrotron X-ray microtomography analysis of pharmaceutical tablets [0.03%]
药物片剂的静态和原位同步辐射微层析研究
Christian Seim,Javier Gerber,Jussi-Petteri Suuronen et al.
Christian Seim et al.
Pharmaceutical solid dosage forms are designed to control drug release timing and location in the body, ranging from immediate-release to delayed-release formulations such as enteric-coated tablets. Ensuring content uniformity, consistent d...
Cell membrane vaccine delivery system: A review of the recent advances against breast cancer [0.03%]
乳腺癌细胞膜疫苗递送系统近期研究进展综述
Ayah Rebhi Hilles,Syed Mahmood,Riyanto Teguh Widodo et al.
Ayah Rebhi Hilles et al.
Natural cells exhibit unique properties, such as homotypic targeting and prolonged circulation in the bloodstream, making them attractive candidates for breast cancer therapy vaccine delivery systems (VDSs). To improve delivery efficiency, ...
Zwitterionic printlets via vat photopolymerisation: A cutting-edge platform for controlled oral drug release systems [0.03%]
基于体积增材制造的两性离子微型打印片：调控口服药物释放的新平台
João Vítor Raupp de Oliveira,Silvio Buchner,Monique Deon et al.
João Vítor Raupp de Oliveira et al.
Vat photopolymerisation 3D printing has attracted considerable interest as an innovative technology for producing personalised medicines. However, the limited availability of materials suitable for printing pharmaceutical forms remains a si...