Investigation of sterile hydrogels as topical vehicles for APOSECTM, a stressed peripheral blood mononuclear cell secretome for the treatment of poorly healing wounds [0.03%]
Dalia Hamid,Lisa Auer,Stefan Mohr et al.
Dalia Hamid et al.
APOSECTM, a complex mixture of secreted proteins, lipids, and exosomes from stressed peripheral blood monocytes, is currently in clinical trials for the treatment of chronic wounds. When applied to open wounds, 1 mL reconstituted APOSECTM l...
Patients in-use stability and safety of repacked delayed-release capsules of sodium divalproex [0.03%]
Mariame A Hassan,Ziyaur Rahman,Mansoor A Khan
Mariame A Hassan
Divalproex Sodium (DVS) is an antiseizure narrow therapeutic index drug. Despite its effectiveness, the primary reason for reduced compliance and/or treatment discontinuation is intolerance to its gastric side effects. Delayed-release forms...
Plant-inspired implantable therapeutic systems: quantitative structure-property-function design of hierarchical biomaterials [0.03%]
Neha Maheshwari,Mayank Sharma,Rahul Maheshwari
Neha Maheshwari
Plant-derived architectures provide a unique reservoir of hierarchical, anisotropic, and transport-optimized design principles that can be systematically translated into functional biomaterials for regenerative implants. Unlike conventional...
Predicting the viability of pharmaceutical formulations for continuous direct compression using machine learning approaches [0.03%]
Laura Pereira Diaz,Stéphanie Marchal,Paul Kroll et al.
Laura Pereira Diaz et al.
Pharmaceutical formulation is the activity in which the chemical substances that form a final medicinal product are combined, including the active pharmaceutical ingredient and excipients. Changes in formulation from variations in excipient...
Predicting early and complete drug release from long-acting injectables using explainable machine learning [0.03%]
Karla N Robles,Manar D Samad
Karla N Robles
Polymer-based long-acting injectables (LAIs) have transformed the treatment of chronic diseases by enabling controlled drug delivery, thus reducing dosing frequency and extending therapeutic duration. Achieving controlled drug release from ...
Influence of formulation parameters on the physicochemical properties and cellular uptake of human serum albumin nanocarriers [0.03%]
Na Li,Wafa T Al-Jamal
Na Li
Human serum albumin (HSA) nanoparticles are promising drug carriers; however, robust control of their physicochemical and biological properties remains challenging. Here, we investigate how formulation parameters, mixing regime and crosslin...
Research status and cutting-edge advances in PEO applications for oral drug delivery systems [0.03%]
Jiaxin Li,Jie Wang,Jie Xu et al.
Jiaxin Li et al.
Regulating the release of drugs precisely is one of the most important aspects of oral drug delivery systems (ODDSs). There are many formulations and preparation techniques for solving this problem, the most widely used is the application o...
Efficacy of a site-specific anti-Nectin-4 antibody-drug conjugate against Nectin-4-positive triple-negative breast cancer models [0.03%]
Fabrice Ngoh Njotu,Moralba Dominguez Garcia,Emmanuel Nwangele et al.
Fabrice Ngoh Njotu et al.
Maleimide-linked antibody-drug conjugates (ADC) like Enfortumab Vedotin (EV) have limited in vivo drug-linker stability. "PODS" is a phenyloxadiazolyl methylsulfone derivatized linker that has been shown to link radioactive payloads to biol...
Preparation of CPD12C15 hyaluronic acid nanoparticles, a novel glycolytic inhibitor and preliminary pharmacologic study on anti-pancreatic cancer [0.03%]
Yafei Feng,Huaiyou Lv,Yinglin Wang et al.
Yafei Feng et al.
Pancreatic cancer (PC) is one of the most insidious malignant tumors with aggressive metastasis and ineffective treatments. Although gemcitabine (GEM) is the gold standard for PC, the acquired resistance and severe myelosuppression limit cl...
A predictive model based on key particle properties for segregation of free-flowing powder blends measured using Near-Infrared spectroscopy [0.03%]
Anna Owasit,Siddharth Tripathi,Rajesh Davé
Anna Owasit
Segregation behavior of binary blends of free-flowing powders was systematically investigated to develop a quantitative model for predicting segregation tendencies as a function of key particle properties. Binary blends, eight training and ...