Application of stimulus-responsive gallium-based liquid metal nano systems in tumor therapy [0.03%]
基于镓的刺激响应型液态金属纳米系统在肿瘤治疗中的应用研究
Xiaolei Wang,Yifei Du,Hongxi Yu et al.
Xiaolei Wang et al.
In recent decades, nanomaterials have achieved remarkable advancements in cancer treatment, leveraging both their intrinsic properties and their roles as drug delivery platforms. Among them, gallium-based liquid metal nanomaterials have eme...
Corrigendum to "Exploring the role of extracellular vesicles in otorhinolaryngology: From diagnostics to therapeutic potential" [Int. J. Pharm. 692 (2026) 126634] [0.03%]
关于“探索外泌体在耳鼻喉科中的作用：从诊断到治疗潜力”的勘误修正[Int. J. Pharm. 692 (2026) 126634]
Farid Fotouhi,Zeinab Nokhbedehghan,Maryam Khajavi et al.
Farid Fotouhi et al.
Effect of electric charge on biotherapeutic transport, binding and absorption: A computational study [0.03%]
电荷对生物治疗载体运输、结合和吸收的影响：一种计算研究方法
Mario de Lucio,Pavlos P Vlachos,Hector Gomez
Mario de Lucio
This study explores the effects of electric charge on the dynamics of drug transport and absorption in subcutaneous injections of monoclonal antibodies (mAbs). We develop a novel mathematical and computational model, based on the Nernst-Pla...
High-loading hyaluronic acid dissolving microneedles for child-friendly dermal and transdermal delivery of doxycycline [0.03%]
一种高负载透明质酸溶解微针用于儿童友好的多西环素经皮和透皮递送
Heba Y Raslan,Mostafa K Mohammad,Asmaa M Nasr et al.
Heba Y Raslan et al.
The clinical utility of doxycycline (DX) in pediatrics is constrained by delivery-related side effects, including dysgeusia, gastrointestinal distress, and phlebitis, which often compromise adherence. Dissolving microneedles (DMNs) represen...
Spray-dried polymeric nanoparticles for enhanced vodobatinib oral dissolution kinetics: formulation design and effects of hydrophobic co-core [0.03%]
喷雾干燥聚合物纳米颗粒增强口服药物vodobatinib溶解动力学：配方设计及疏水性共核的影响
Sophia R Dasaro,Kurt Ristroph
Sophia R Dasaro
Vodobatinib, a third-generation tyrosine kinase inhibitor, exhibits limited oral bioavailability in its crystalline form, necessitating intensive dosing regimens. Here, we sought to improve the oral dissolution kinetics of vodobatinib throu...
Impact of macrophages on the dissolution of LAI suspension prodrugs [0.03%]
巨噬细胞对LAI悬浮型前药制剂溶解行为的影响研究
Nilesh Malavia,Kellen Maurus,Melissa Sabatella et al.
Nilesh Malavia et al.
Long-acting injectable (LAI) suspensions are often designed to provide sustained drug release by exploiting the low aqueous solubility of poorly soluble drugs or prodrugs. While particle size remains the foundational determinant of drug rel...
Microneedle dressing incorporating deferoxamine-loaded silk fibroin nanoparticles for diabetic wound therapy [0.03%]
一种新型微针贴剂用于糖尿病创面治疗
Elaf Mahmood Shihab,Saja Majeed Shareef,Zinah Essam Hameed et al.
Elaf Mahmood Shihab et al.
Managing diabetic wounds remains a complex biomedical challenge due to impaired vascularization, persistent inflammation, and limited drug penetration. This study presents a microneedle (MN) dressing composed of a carrageenan-Soluplus® mat...
High viscosity microenvironment induces chemoresistance of cancer cells through upregulating P-gp [0.03%]
高黏度微环境通过上调P-糖蛋白诱导癌细胞耐药性
Guanlin Zhou,Chengwei Wu,Wei Zhang
Guanlin Zhou
Chemoresistance remains a major obstacle to the efficacy of cancer chemotherapy. The tumor mechanical microenvironment such as substrate stiffness, fluid shear stress, and solid stress can considerably influence drug resistance. Compared wi...
Hydroxypropyl-β-cyclodextrin as a multifunctional excipient for enhancing stability and aerosol performance of spray-dried protein formulations [0.03%]
羟丙基-β-环糊精作为多功能辅料增强喷雾干燥蛋白制剂稳定性和气溶胶性能的研究
Yuchen Yang,Qingyi Zhu,Hriday Bera et al.
Yuchen Yang et al.
Protein-based drugs are precise therapeutic options for various refractory lung diseases, significantly improving patient prognosis and quality of life. In this study, a comparative spray-drying approach was employed to prepare inhalable dr...
α-Lactose monohydrate - new insights into physicochemical response to temperature and humidity exposure [0.03%]
α-乳糖一水合物——温度和湿度影响下的物理化学性质的新认识
Andrea Sanchez-Valencia,Johanna Husman-Piirainen,Päivi Kokkonen et al.
Andrea Sanchez-Valencia et al.
Environmental relative humidity (RH) and temperature (T) are known to be promoters of physicochemical changes in pharmaceutical grade lactose, either in controlled (supervised conditioning), or uncontrolled (during transit and repository st...