Bottom-up particle engineering via solvent-mediated polymorphic transformation: a novel strategy for pharmaceutical processability enhancement [0.03%]
通过溶剂介导多形转化自下而上进行颗粒工程以提高药物可加工性的新策略
Elizabeth Horstman,Ernest Carra,Vijay Dhand et al.
Elizabeth Horstman et al.
Bictegravir free acid exhibits one of the most complex polymorph landscapes reported for pharmaceutical compounds, presenting both a significant development challenge and a unique engineering opportunity. During the development of a long-ac...
Waiting Tai,Pancy Tsz Hei Kwong,Grace Tsz Yan Yau et al.
Waiting Tai et al.
Human platelet lysate (PL) is a mixture of proteins containing growth factors, cytokines, and other biomolecules. PL shows promising effects on tissue regeneration and immunomodulation and may be applied to the lungs. Inhalation enables dir...
Nanomaterial-based modulation of inflammatory and cytokine networks for precision therapy in inflammatory bowel disease [0.03%]
基于纳米材料的炎症性和细胞因子网络在炎症性肠病精确治疗中的调节作用
Yunshuang Wang,Yuting Nan,Ke Zhang et al.
Yunshuang Wang et al.
Inflammatory bowel disease (IBD), including Crohn' s disease and ulcerative colitis, is characterized by chronic intestinal inflammation driven by complex interactions among immune cells, intestinal epithelial cells, and the gut microbiota....
Photodynamic treatment of onychomycosis using bacterial nanocellulose patches for photosensitizer delivery [0.03%]
用于光敏剂递送的细菌纳米纤维素贴片的光动力治疗甲真菌病研究
Francesca Mancusi,Mara Wesinger,Nidia Maldonado-Carmona et al.
Francesca Mancusi et al.
The high prevalence of onychomycosis, a common pathology of nails due to fungal infections, has drawn attention to the development of new therapeutic approaches in which systemic secondary effects and the rise of drug resistance are avoided...
Inhalable solid lipid nanoparticles of cyclosporine A for prolonged pulmonary exposure: nano-in-micro particles prepared with fine droplet drying process [0.03%]
环孢素A肺递送吸入固脂质纳米粒的制备及其微纳复合颗粒干燥工艺研究
Hideyuki Sato,Asuka Nakazawa,Tatsuru Moritani et al.
Hideyuki Sato et al.
This study aimed to achieve prolonged pulmonary exposure of cyclosporine A (CsA) by developing an inhalable powder of solid lipid nanoparticles (SLN). The fine droplet drying (FDD) process, a powderization technique employing printing techn...
Improving the efficacy of tazarotene in psoriasis via bilosomal gel delivery: in vitro characterization, ex vivo evaluation, and preclinical assessment in an imiquimod induced psoriasis in a rat model [0.03%]
通过双脂质体凝胶递送改善塔拉塞诺在银屑病疗效：体外特征，离体评估和在咪喹莫特诱导的大鼠银屑病模型中的临床前评估
Mai El Halawany,Mai M El Taweel,Khadra Soliman et al.
Mai El Halawany et al.
Bilosomes (BLs) loaded with tazarotene (TZ) were developed to enhance dermal delivery for psoriasis management. Vesicles were prepared using the thin-film hydration technique and optimized using 32 full factorial design to maximize entrapme...
Dermapen-mediated microchannels enable deep cutaneous delivery of liposomal and particulate model systems, with topical massage as an additional enhancer [0.03%]
微针介导的微通道能够使liposome和颗粒模型系统实现深度透皮递送，外用按摩作为增效手段
Yasmin Raad Al-Maliki,Maimuna Ahmed,Noor M Al-Tewaj et al.
Yasmin Raad Al-Maliki et al.
Delivering hydrophilic macromolecules and particulate systems into skin is limited by the strong transport resistance of the stratum corneum and viable epidermis. Microneedling offers a potential solution, but its usefulness depends on whet...
Ready-to-use, spheronized drug particles-embedded iron(III)-reinforced carboxymethyl cellulose hydrogels as novel long-acting injectable platform with reduced local inflammation [0.03%]
一种新型长效注射平台：用于减少局部炎症的预装式负载铁(III)增强羧甲基纤维素水凝胶的球形药物颗粒
Min Young Jeong,Do Myeong Shin,In Gyu Yang et al.
Min Young Jeong et al.
This study aimed to construct a ready-to-use, spheronized drug particle-embedded iron(III)-reinforced carboxymethyl cellulose hydrogel (Fe3+-CMC HG) as a novel long-acting injectable (LAI) platform for hydrophobic drugs. Dutasteride (DTS), ...
Bioactive glutathione-modified carboxymethyl cellulose hydrogels as levofloxacin delivery platforms for the Staphylococcus aureus-infected wounds management [0.03%]
谷胱甘肽化羧甲基纤维素抗菌水凝胶敷料促进左氧氟沙星治疗金黄色葡萄球菌感染创面
Tianbao Wang,Yaqin Yang,Ya Zhuo et al.
Tianbao Wang et al.
Bacterial infection severely impairs wound healing, and current therapeutic strategies are limited due to their poor antibacterial efficacy and potential bio-toxicity. Herein, a novel multifunctional hydrogel (CGBAgel) was fabricated with g...
Multiple prodrug approach for topical application: flux across silicone membranes upon simultaneous administration of salicylate esters [0.03%]
通过硅胶膜同时给药水杨酸酯时的多前药方法的透皮吸收研究
Hannah Grønbech Kolberg,Adrian Gjetnes Rossebø,Margaux Civat et al.
Hannah Grønbech Kolberg et al.
The barrier properties of the skin constitute a major challenge to topical drug delivery, motivating strategies to increase transmembrane flux. This study evaluates a multiple prodrug approach using salicylic acid and eight structurally rel...