Plasmodium falciparum ring-infected erythrocyte surface antigen 3 (PfRESA3) is a cytoskeleton-interacting protein and potential co-chaperone [0.03%]
一种疟原虫环期感染红细胞表面抗原蛋白(PfRESA3)是一种细胞骨架相互作用蛋白和潜在辅助分子 chaperone 蛋白
Nipa Rani Mallick,Welka Sahu,Deepak Kumar Ojha et al.
Nipa Rani Mallick et al.
Plasmodium falciparum exports proteins into host erythrocytes for survival, but the roles of many of these proteins remain unexplored. Here, we used recombinant protein constructs and antibodies corresponding to Plasmodium falciparum ring-i...
Hyperosmotic stress induces PARP1-mediated HPF1-dependent mono(ADP-ribosyl)ation [0.03%]
高渗压力可诱导PARP1介导的HPF1依赖性单（ADP核糖基）化作用
Anna Georgina Kopasz,Mihály Mérey,Rebeka Vásárhelyi et al.
Anna Georgina Kopasz et al.
While the downstream effectors of the hyperosmotic stress response are relatively well characterized, the primary molecular sensors responsible for initial stress detection remain poorly defined. In this study, we demonstrate that hyperosmo...
Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders [0.03%]
线粒体病相关神经发育缺陷与神经发生、少突胶质细胞发生及髓鞘形成异常的关系
Sahitya Ranjan Biswas,Porter L Tomsick,Alicia M Pickrell et al.
Sahitya Ranjan Biswas et al.
Primary mitochondrial disorders (PMDs) are inherited metabolic diseases that most often present with neurological symptoms in infancy or adolescence, underscoring the central importance of mitochondrial function to brain health. Historicall...
Carrie L Partch
Carrie L Partch
Chemical biology approaches to study and target circadian clocks and their components [0.03%]
化学生物学方法研究和靶向昼夜钟及其组分
Emmanuel F Rivera-Iglesias,Mohamed A Elanany,Michelle E Farkas
Emmanuel F Rivera-Iglesias
Circadian rhythms are biological cycles of approximately 24 h that align physiology and behavior with the solar day, helping organisms coordinate their functions with the light/dark cycle. These rhythms are generated by molecular circadian ...
A methionine-lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase [0.03%]
甲硫氨酸活性位点决定细菌萜类合成酶的碳正离子稳定性和产物特异性
Marion Ringel,Carl P O Helmer,Shani Zev et al.
Marion Ringel et al.
Terpene synthases (TPSs) generate complex hydrocarbon scaffolds through carbocationic cyclization cascades that demand precise active-site control to stabilize reactive intermediates. While π-cation and electrostatic interactions are estab...
Valosin-containing protein counteracts ATP-driven dissolution of FUS condensates through its ATPase activity in vitro [0.03%]
含Valosin蛋白通过其ATP酶活性对抗FUS凝聚物的ATP驱动解体作用（体外研究）
Hitomi Kimura,Shin-Ichi Tate,Kyota Yasuda
Hitomi Kimura
Fused in sarcoma (FUS) forms phase-separated condensates implicated in amyotrophic lateral sclerosis (ALS). Although millimolar ATP concentrations paradoxically dissolve FUS condensates through hydrotropic activity, condensates nevertheless...
The Xkr protein family-From apoptosis executors to diverse physiological functions regulators [0.03%]
Xkr蛋白家族--从凋亡执行者到多种生理功能的调节者
Qing Yan,Xinyu Ma,Liping Wang et al.
Qing Yan et al.
The asymmetry of the phospholipids in the cell membrane is fundamental to maintaining normal cellular physiological functions. Phosphatidylserine (PS), a key phospholipid, is typically restricted to the inner side of the plasma membrane. Ho...
Alternative polyadenylation releases PCBP1-mediated suppression of CFIm25 during macrophage differentiation [0.03%]
替代多腺苷酸化在巨噬细胞分化期间释放PCBP1介导的CFIm25抑制作用
María Del Pilar Mendoza-Martín,Salwa Mohd Mostafa,Atish Barua et al.
María Del Pilar Mendoza-Martín et al.
CFIm25, a key component of the cleavage factor Im (CFIm) complex needed for mRNA 3' end processing, shows increased protein expression during monocyte-to-macrophage differentiation despite stable mRNA levels. We demonstrate that poly(C)-bin...
Interactions of Escherichia coli SMC-like RecN protein with different forms of DNA at the single-molecule level [0.03%]
单分子水平下大肠杆菌SMC样RecN蛋白与不同类型DNA的相互作用
Viktoria Dmitrievna Roshektaeva,Aleksandr Andreevich Alekseev,Valeria Denisovna Vorobieva et al.
Viktoria Dmitrievna Roshektaeva et al.
Exposure to various environmental factors and endogenous agents can lead to double-strand DNA breaks. Bacteria are capable of restoring their genome integrity through a process known as the SOS response, which requires the RecA recombinase....