Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics [0.03%]
周边溶酶体将PLEKHG3募集到焦黏着斑并抑制突起动力学
Rainer Ettelt,Ana-Maria Sandru,Georg Vucak et al.
Rainer Ettelt et al.
Lysosomes are dynamic organelles regulating metabolic signaling by recruiting cytosolic molecules to protein platforms on their limiting membrane. We used proximity labeling to define interactors and vicinal proteins of LAMTOR3, a component...
The sweet spot in protein design-Where deep learning meets first principles [0.03%]
蛋白质设计中的甜区—深度学习与基本原理的结合点
Gabriel Cia,Gabriele Orlando,Damiano Cianferoni et al.
Gabriel Cia et al.
This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-pr...
Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila [0.03%]
营养物/TOR信号控制脂肪组织线粒体转录因子A(TFAM)以调节果蝇的生长
Shrivani Sriskanthadevan-Pirahas,Shahoon Khan,Abhishek Sharma et al.
Shrivani Sriskanthadevan-Pirahas et al.
Animals must adapt their growth to fluctuations in nutrient availability to ensure proper development. While nutrient-sensing tissues coordinate organismal growth through interorgan signaling, the metabolic changes within these tissues that...
Microbiome-blood-brain barrier interactions in aging - mechanisms and therapeutic potential [0.03%]
衰老中的菌群-血液屏障相互作用：机制与治疗潜力
Daniel Cuervo-Zanatta,Hari Baskar Balasubramanian,Amir Pasokh et al.
Daniel Cuervo-Zanatta et al.
Age-related decline in neurovascular integrity is an increasingly recognized contributor to cognitive impairment and neurodegenerative vulnerability. A central feature is blood-brain barrier (BBB) dysfunction arising from endothelial senesc...
Kati Fischermanns,Johannes Broichhagen
Kati Fischermanns
Transmembrane-spanning cell surface proteins undergo maturation from the site of synthesis in the endoplasmic reticulum to the plasma membrane, and may be endocytosed back into the cell. Microscopy allows the visual separation of such popul...
Alex J Vecchio
Alex J Vecchio
Claudins regulate molecular transport between cells via the paracellular route at tight junctions in epithelial and endothelial tissues and are prime targets for biologic therapies. Claudin-claudin interactions through their extracellular s...
RETRACTION: MicroRNA-106b Regulates the Tumor Suppressor RUNX3 in Laryngeal Carcinoma Cells [0.03%]
撤稿：微小核糖核酸-106b通过调节喉癌细胞肿瘤抑制蛋白RUNX3表达发挥促凋零作用
Y. Xu, K. Wang, W. Gao, C. Zhang, F. Huang, S. Wen and B. Wang, "MicroRNA-106b Regulates the Tumor Suppressor RUNX3 in Laryngeal Carcinoma Cells," FEBS Letters 587, no. 19 (2013): 3166-3174, https://doi.org/10.1016/j.febslet.2013.05.069. Th...
An epithelial GPR35 isoform supports tumor-associated transcriptional and metabolic phenotypes [0.03%]
一种上皮GPR35同种型支持肿瘤相关转录和代谢表型
Jørgen D Rønneberg,Martine Hjeltnes,Josephine Krieger et al.
Jørgen D Rønneberg et al.
G protein-coupled receptor 35 (GPR35) has been implicated in cancer, but the functional roles of its isoforms remain unresolved. Here, we characterize GPR35-long, an N-terminally extended epithelial isoform selectively enriched in colorecta...
Loss of LipT2 disrupts mitochondrial protein lipoylation and metabolic homeostasis in Drosophila melanogaster [0.03%]
果蝇LipT2丧失导致线粒体蛋白脱辅基和代谢稳态失调
Yoshihito Kishita,Manabu Tsuda,Yukiko Sato-Miyata et al.
Yoshihito Kishita et al.
Lipoic acid is an essential cofactor for mitochondrial multienzyme complexes involved in central metabolism. In humans, mutations in the lipoyl transferase LIPT2 impair mitochondrial protein lipoylation and cause severe metabolic disease. H...
From outflow tract development to ventriculo-arterial discordance - Developmental and genetic mechanisms of d-TGA and ccTGA [0.03%]
流出道发育到心室流出道连接异位：大动脉转位（d-TGA）和永存左上腔静脉型大动脉转位（ccTGA）的发育及遗传机制
Ségolène Bernheim,Marine Tortigue,Stanislao Igor Travisano et al.
Ségolène Bernheim et al.
Discordant ventriculo-arterial (VA) connection characterizes dextro-transposition of the great arteries (d-TGA) and congenitally corrected transposition of the great arteries (ccTGA). These distinct defects involve overlapping developmental...