KSRP-dependent immunogenic cell death induced by pyridazinone derivative IMB5036 drives antitumor immunity in neuroblastoma [0.03%]
依克索丁衍生物IMB5036诱导的KSRP依赖性免疫原性细胞死亡驱动神经母细胞瘤抗肿瘤免疫反应
Yanqun Dong,Yanfeng Xu,Junyi Zhang et al.
Yanqun Dong et al.
The small-molecule pyridazinone derivative IMB5036 (IMB) exhibits significant cytotoxicity against multiple cancer cell lines, and KH-type splicing regulatory protein (KSRP) is confirmed as its direct binding partner. However, KSRP's functi...
Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity [0.03%]
Septin 9蛋白的PB结构域协调中心体定位和微管乙酰化以控制上皮极性
Ting Ting Cai,Mohyeddine Omrane,Nassima Benzoubir et al.
Ting Ting Cai et al.
Septins are cytoskeletal GTP-binding proteins that organize microtubules and scaffold polarity complexes. Here, we uncover a polybasic (PB)-domain-dependent mechanism by which septin 9 controls apico-basal polarity in epithelial cells. Sept...
EGFR signaling determines the differentiation routes of neuroepithelial cells in the visual center of Drosophila [0.03%]
EGFR信号决定果蝇视觉中心神经上皮细胞的分化方向
Mire Hirose-Shimizu,Misora Ikeda,Rino Sato et al.
Mire Hirose-Shimizu et al.
The developing central nervous system is regionalized into different domains to generate functionally distinct brain structures. Although this regionalization is crucial for constructing a functional brain, its regulatory mechanisms remain ...
Cryo-electron microscopy fuels the architectural characterization of cellular metabolism [0.03%]
cryo电子显微镜技术促进细胞代谢架构的表征
Panagiotis L Kastritis
Panagiotis L Kastritis
Atomic force microscopy-based nanomechanical signatures as cancer biomarkers in a nutshell [0.03%]
基于原子力显微镜的纳米力学特征作为癌症生物标志物的概况分析
Andreas Stylianou
Andreas Stylianou
Atomic force microscopy-AFM enables label-free quantification of cellular and tissue mechanics with nanoscale resolution under near-physiological conditions, providing access to physical properties that are not captured by conventional appr...
TG-interacting factor 1 mediates TNF-induced Ccl2 expression in adipocytes to promote prostate cancer progression [0.03%]
肿瘤坏死因子诱导的脂肪细胞中TG互作因子1介导的Ccl2表达促进前列腺癌进展
Kuan-Hua Huang,Hung-Wen Tsai,Yu-Pu Chu et al.
Kuan-Hua Huang et al.
Periprostatic adipose tissue secretes chemokines and lipid mediators that, particularly in the context of obesity, enhance prostate cancer cell (PCa) migration and invasion. Treating 3 T3-F442A pre-adipocytes with conditioned medium (CM) fr...
Unstructured but dangerous-the emerging roles of intrinsically disordered protein regions in bacterial pathogenesis [0.03%]
无序但仍具危险性-细菌致病中内在无序蛋白区域的新兴作用
Diego Forni,Rachele Cagliani,Manuela Sironi
Diego Forni
Intrinsically disordered regions (IDRs) constitute a substantial portion of eukaryotic proteomes but are less prevalent in prokaryotes. Nevertheless, accumulating evidence reveals that IDRs play crucial roles in bacterial virulence, niche a...
Crystal structure of Mycobacterium tuberculosis mycothione reductase in complex with a specific inhibitor reveals competition with NADP(H) binding [0.03%]
与特异抑制剂结合的结核杆菌类硫化合物还原酶复合物晶体结构揭示了其与NADPH的竞争性结合模式
Lauren Oorts,Evgenii M Osipov,Steven Beelen et al.
Lauren Oorts et al.
Tuberculosis (TB) remains a major health threat, while the increasing occurrence of drug-resistant strains underscores the need for new antitubercular drugs. A promising strategy to combat TB is based on disrupting the mycobacterial redox h...
The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions [0.03%]
来自不同大鼠和小鼠脑区线粒体的丙酮酸生成现象普遍存在
Grazyna Debska-Vielhaber,Niki Karavasili,Matthias Kunz et al.
Grazyna Debska-Vielhaber et al.
The finding of the pyruvate generator ('mitochondrial gas pedal') arose from the observation that cytosolic Ca2+ accelerates glutamate-driven respiration. Here, we show that glutamate respiration of isolated rat brainstem mitochondria appea...
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase [0.03%]
纳豆激酶降解von Willebrand因子A2结构域的机制研究
Ryuichi Hyakumoto,Masatomo So,Ayako Furukawa et al.
Ryuichi Hyakumoto et al.
Von Willebrand factor (vWF) is central to hemostasis, yet its ultralarge multimers promote arterial thrombosis. Nattokinase, a natto-derived serine protease, reduces plasma vWF levels, but the underlying mechanism remains unclear. Here, we ...