Advancing physical virology through multiscale approaches-Insights from the 2025 FEBS|EMBO lecture course 'Physical Virology: across length scales' [0.03%]
多尺度方法推动物理病毒学的发展——2025年FEBS|EMBO课程《物理病毒学：跨越长度尺度》的启示
Ekaterina Selivanovitch,Christian Sieben,Roger Castell-Graells et al.
Ekaterina Selivanovitch et al.
Viruses represent a major threat to human health, while simultaneously exhibiting great potential in a wide range of applications, from virus-inspired devices to therapeutic delivery agents. Addressing virus-related questions from an interd...
Editorial
FEBS letters. 2026 Jun 10. DOI:10.1002/1873-3468.70359 2026
The ovarian cost of convenience-Human studies on phthalate exposure and ovarian function [0.03%]
邻苯二甲酸盐暴露与卵巢功能的研究进展
Mayara Cristina Batista da Silva,Katariina Johanna Saretok,Inge Varik et al.
Mayara Cristina Batista da Silva et al.
Phthalates are ubiquitous environmental contaminants and suspected endocrine disruptors, used as plasticizers and constituents of fragrances. Regulation of their use in consumer products has largely been guided by male reproductive outcomes...
LncRNA YIYA drives pancreatic cancer proliferation under high-glucose conditions by reinforcing a RAS-PKM2-dependent Warburg phenotype [0.03%]
长链非编码RNA YIYA通过增强RAS-PKM2依赖性的瓦堡表型促进高糖条件下胰腺癌的增殖
Nachiket Dattatray Garge,Ankita Sharma,Sudeshna Mukherjee et al.
Nachiket Dattatray Garge et al.
Hyperglycaemia is an independent risk factor for pancreatic cancer (PC). Here, we show that both chronic and intermittent high glucose cause a robust upregulation of the novel lncRNA LINC00538 (YIYA) in pancreatic ductal adenocarcinoma (PDA...
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila [0.03%]
泛素化通过类吞噬作用降解分泌颗粒以调控果蝇的激素稳态
Tamás Csizmadia,Anna Dósa,Asha Kiran Maddali et al.
Tamás Csizmadia et al.
Gland cells dynamically regulate their secretory granule content via balancing synthesis, maturation, secretion, and lysosomal degradation (crinophagy). However, the signal(s) leading to crinophagic breakdown of secretory granules are unkno...
Inbar Yosibash,Raya Sorkin
Inbar Yosibash
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to p...
Interaction and co-phase separation of SARS-CoV-2 nucleocapsid protein and human hnRNPA1 and its implications for viral life cycle [0.03%]
SARS-CoV-2核衣壳蛋白与人类hnRNPA1的相互作用及共相分离及其对病毒生命周期的影响
Parul Gupta,Risabh Sahu,Iman Nandi et al.
Parul Gupta et al.
The nucleocapsid (N) protein of SARS-CoV-2 is central to viral assembly and replication. It binds the viral RNA to form a helical nucleocapsid and enables genome packaging and its release into host cells. Human heterogeneous nuclear ribonuc...
An unexpected alternative viologen electron mediator site in tungsten-containing formate dehydrogenase [0.03%]
含钨甲酸脱氢酶中出人意料的维生素M传电子位点
Eleni G Poloniataki,Yong Hwan Kim
Eleni G Poloniataki
The molecular mechanisms by which artificial electron mediators, such as ethyl viologen (EV), interact with tungsten-containing formate dehydrogenases (FDHs) during reversible CO2 reduction remain poorly understood. Here, we reveal an unexp...
The ubiquitin-proteasome system and autophagy as guardians of the cellular proteome [0.03%]
泛素-蛋白酶体系统和自噬在维护细胞蛋白质组中的作用
Ivan Dikic
Ivan Dikic
Maintaining a functional proteome is essential for cellular health and organismal longevity. Disruption of proteostasis is a hallmark of aging and a central driver of diverse pathologies, including neurodegeneration, cancer, and metabolic d...
Modulation of Homer1 EVH1 domain internal dynamics by putative autism-associated mutations [0.03%]
与自闭症相关的突变对Homer1 EVH1结构域内动态的调节作用研究
Fanni Farkas,Brigitta Maruzs,Zsófia E Kálmán et al.
Fanni Farkas et al.
The EVH1 domain of the Homer1 scaffold protein interacts with the proline-rich region of Shank3, forming a key network within the postsynaptic density. While two mutations (M65I and S97L) in the EVH1 domain have been suggested to be associa...
Rab14 regulates the transport of human papillomavirus to the trans-Golgi network for infectious cell entry [0.03%]
Rab14调节人乳头瘤病毒向反式高尔基网络的运输以进行感染细胞进入
Yoshiyuki Ishii,Iwao Kukimoto
Yoshiyuki Ishii
Human papillomavirus (HPV) utilizes multiple host proteins to infect epithelial cells. Here we identified Rab14, a small GTPase belonging to the Rab family, as a critical host factor in HPV infection. Rab14 knockout (KO) cells exhibited res...