Aleshia Seaton-Terry,Alexander J Cutright,Mong Na Claire Loi et al.
Aleshia Seaton-Terry et al.
Inositol phosphates (IPs) and phosphoinositide lipids (PIPs) are regulatory molecules critical for a wide array of functions in eukaryotic cells. Membrane PIPs have clear functions in transient recruitment of signaling proteins to membranes...
From mice to humans-divergent strategies for intestinal homeostasis and regeneration [0.03%]
从鼠到人——肠道稳态与再生的分化策略
Keiko Ishikawa,Shinya Sugimoto,Toshiro Sato
Keiko Ishikawa
The intestinal epithelium is maintained by stem cells that balance self-renewal and differentiation to sustain homeostasis and enable regeneration after injury. Recent advances-including organoid culture, genome editing, orthotopic xenotran...
RETRACTION: ATF4 Activation by the p38MAPK-eIF4E Axis Mediates Apoptosis and Autophagy Induced by Selenite in Jurkat Cells [0.03%]
撤回：ATF4激活通过p38 MAPK-eIF4E轴介导硒ite在Jurkat细胞中诱导的凋亡和自噬
Q. Jiang , F. Li , K. Shi , P. Wu , J. An , Y. Yang and C. Xu , "ATF4 Activation by the p38MAPK-eIF4E Axis Mediates Apoptosis and Autophagy Induced by Selenite in Jurkat Cells," FEBS Letters 587, no. 15 (2013): 2420-2429, https://doi.org/10...
Microbiome-host proteostasis crosstalk-An emerging perspective on mechanisms and interventions toward healthy longevity [0.03%]
微生物组-宿主蛋白质稳态互作——健康长寿机制和干预的新兴视角
Abhishek Anil Dubey,Maria Ermolaeva
Abhishek Anil Dubey
Proteostasis and the gut microbiota are two major determinants of host health and longevity. Proteostasis ensures proper protein folding and degradation thereby preventing the accumulation of unwanted proteins. Similarly, microbiota contrib...
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis [0.03%]
产碱菌包膜生物合成的结构见解和治疗目标
Woo Cheol Lee,Junho Jeong,Chae Yeong Lee et al.
Woo Cheol Lee et al.
Gram-negative bacteria produce nonulosonic acids, a family of nine-carbon sugars that mimic host sialic acids and may contribute to bacterial virulence. The nonulosonic acid C8-epimeric 5,7-di-N-acetyllegionaminic acid (8-epi-Leg5,7Ac2) is ...
PARK(ing) time-How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease [0.03%]
停车时间-帕金森病果蝇模型中的公园缺乏如何影响生物钟
Kamila Zientara,Kinga Skoczek,Elzbieta Pyza et al.
Kamila Zientara et al.
Sleep and circadian disruptions are early symptoms of Parkinson's disease (PD), which is one of the most common neurodegenerative disorders. However, PD has an idiopathic origin, and the factors accelerating the progression of symptoms are ...
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes [0.03%]
酿酒酵母线粒体膜中复合物III和IV之间的电子转移
Ana Paula Lobez,Mikael Oliveberg,Peter Brzezinski
Ana Paula Lobez
Mitochondrial oxidative phosphorylation relies on cytochrome c transferring electrons between complexes III and IV. Earlier studies using detergent-purified complex III-IV supercomplexes from S. cerevisiae showed that this transfer is limit...
PDIA1 promotes androgen receptor activation and prostate cancer cell survival through enhancing HMMR stability [0.03%]
PDIA1通过增强HMMR稳定性来促进雄激素受体活化和前列腺癌细胞存活
Sishu Yu,Zijian Kuang,Ping Yao et al.
Sishu Yu et al.
To sustain rapid proliferation, cancer cells increase protein synthesis, intensifying reliance on protein disulfide isomerase A1 (PDIA1). It is largely unknown whether disulfide bond formation of PDIA1 substrates is driven by one or both CG...
Differential recruitment of acetylcholine vesicle pools by electrical stimulation and KCl depolarization in cholinergic nerve terminals [0.03%]
胆碱能神经节中乙酰胆碱囊泡库通过电刺激和KCl去极化募集的差异性
Ikunobu Muramatsu,Junsuke Uwada,Itsumi Nagai-Arakawa et al.
Ikunobu Muramatsu et al.
Depolarizing stimuli regulate acetylcholine (ACh) storage and release via distinct synaptic vesicle pools in cholinergic terminals, but the mechanisms remain unclear. Here, we examined the effects of preliminary depolarization on choline up...
Revisiting Alphavirus RNA packaging and assembly-A complex story with multiple angles [0.03%]
再访 alphavirus RNA 包装和组装：多角度的复杂故事
Mauricio Comas-Garcia
Mauricio Comas-Garcia
Alphavirus is a genus of enveloped, single-stranded positive-sense RNA viruses with an icosahedral virion consisting of two T = 4 layers. These viruses are transmitted by invertebrates, are present in almost every ecosystem, and infect a wi...