Modelling stem cell differentiation related processes-A practical overview for biologists [0.03%]
干细胞分化相关过程的建模——生物学家实用概览
Ricco Zeegelaar,Xinqi Yan,Lucas Jansen Klomp et al.
Ricco Zeegelaar et al.
Stem cell differentiation is central to development and regenerative medicine, but the complex underlying processes hinder our ability to control it experimentally. Computational models can help form hypotheses and generate predictions. The...
Overlapping gut microbiome signatures in aging and disease are characterized by enrichment of medication-associated oral microbes in the gut [0.03%]
衰老和疾病之间的重叠肠道微生物标志物特征是口腔微生物在肠道中富集
Nidhi P Raval,Debarshi Roy,Alisha Ansari et al.
Nidhi P Raval et al.
Biological aging is associated with gut microbiome alterations, including depletion of commensals and enrichment of disease-linked pathobionts. However, the extent to which these changes overlap with disease-associated microbiome signatures...
Csk binding to integrin β3 is regulated by tyrosine and threonine phosphorylation of β3 [0.03%]
整合素β3酪氨酸和苏氨酸磷酸化调控其与CSK的结合
Esa T Mikkola,Carl G Gahmberg
Esa T Mikkola
C-terminal Src kinase (Csk) is crucial for the normal function of platelet integrin αIIbβ3 because it inactivates Src kinase. While the molecular mechanism by which cytoplasmic Csk associates with membrane-bound Src is known in resting pl...
Mixed-class J-domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly [0.03%]
混合类J型结构域蛋白支架促进功能去折叠酶组装过程中扩增聚集物处理和多价Hsp70结合
Anna Szlachcic,Nadinath B Nillegoda
Anna Szlachcic
Protein aggregates threaten cellular proteostasis and are linked to aging and disease. In metazoa, aggregate resolution relies on Hsp70-J-domain protein (JDP)-based disaggregases. Previous studies showed human class A and class B JDP assemb...
Mark Olenik,İsmail Güderer,Yi Wang et al.
Mark Olenik et al.
The gut microbiome changes systematically with age and associates with age-related morbidity and mortality, establishing it as a candidate biomarker and intervention target for ageing. Realising this potential requires methodological rigour...
Lukas Drexler,Markus R Busch,Reinhard Sterner
Lukas Drexler
It is important to understand how the fascinating diversity of modern enzymes has manifested itself since the onset of life. A powerful approach to address this question is the computational and experimental retracing of evolutionary proces...
Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates [0.03%]
三个磷酸酶家族形成一个社区：作用于肌醇多磷酸的磷酸水解酶
Ronda J Rolfes
Ronda J Rolfes
Inositol pyrophosphates (PP-InsP) are high energy signaling molecules that play important roles in eukaryotes. They are synthesized from inositol polyphosphates by kinases that add a diphosphate (β phosphate) at one or more positions on th...
Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy [0.03%]
细胞几何和膜蛋白拥挤限制了大肠杆菌的生长速率、代谢溢出、呼吸和维持能量
Ross P Carlson,Tomáš Gedeon,Mauricio Garcia Benitez et al.
Ross P Carlson et al.
The rules of prokaryotic cell design remain elusive. Here, a theory is presented for interpreting growth rate, overflow metabolism, respiration efficiency, and maintenance energy flux based on cell dimensions, membrane protein crowding, and...
Salmonella lipopolysaccharide-containing supported lipid bilayers as platforms to study bacteriophage interactions [0.03%]
含鼠伤寒沙门氏菌脂多糖的支撑液态薄膜作为噬菌体相互作用研究平台
Hudson P Pace,Alyssa Borges,Charles Arnaud et al.
Hudson P Pace et al.
Lipopolysaccharides (LPS) are a key component in the defensive barrier of the outer membrane (OM) of Gram-negative bacteria; they are a major drug target and bacteriophage access point. Biomimetic platforms presenting LPS are therefore impo...
ABL kinase-dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains [0.03%]
ABL激酶依赖的SH蛋白磷酸化促进其与CRK家族SH2结构域直接结合
Phoebe M Cousens,Brendan W Chandler,Anna M Schmoker et al.
Phoebe M Cousens et al.
CT10 regulator of kinase (CRK) and CRK-Like (CRKL) are important Src homology 2 (SH2)- and SH3-domain containing signaling adaptors, which drive cell adhesion, motility, differentiation, and proliferation. Their genetically defined and over...