Class II HDAC Clr3-mediated H2B deacetylation promotes DNA damage and replication stress response in Schizosaccharomyces pombe [0.03%]
克鲁斯曼氏短梗霉中组蛋白脱乙酰酶Clr3介导的H2B去乙酰化促进DNA损伤和复制压力响应
Li Liu,Ruifan Zhu,Jinzhou Yin et al.
Li Liu et al.
DNA damage and replication stress cause genome instability. Histone H3/H4 deacetylation by class I histone deacetylases (HDACs) and H3 methylation by histone methyltransferases promote DNA repair and fork stability. However, other histone m...
RETRACTION: Role of Phospholemman and the 70 kDa Inhibitor Protein in Regulating Na+/K+ ATPase Activity in Pulmonary Artery Smooth Muscle Cells under U46619 Stimulation [0.03%]
撤回：磷脂蛋限蛋白和70kda抑制蛋白在U46619刺激下肺动脉平滑肌细胞中Na+/K+ATP酶活性中的作用
K. Dey , S. M. Rahaman , T. Chakraborti , and S. Chakraborti , "Role of Phospholemman and the 70 kDa Inhibitor Protein in Regulating Na+/K+ ATPase Activity in Pulmonary Artery Smooth Muscle Cells under U46619 Stimulation," FEBS Letters 587,...
Conserved binding mode but diverse interfaces of MreC-PBP2 interactions [0.03%]
MreC-PBP2相互作用的保守结合模式与多样的界面
Hyunseok Jang,Hyo Been Jin,Chang Min Kim et al.
Hyunseok Jang et al.
MreC is an essential periplasmic component of the bacterial elongasome that regulates peptidoglycan synthesis through interaction with PBP2. Here, we report the crystal structure of MreC from Acinetobacter baumannii (abMreC) at 2.49 Å reso...
Investigating transcription factor dynamics in health and disease using FRAP [0.03%]
利用FRAP技术研究健康状态和疾病状态下转录因子的动态变化规律
Kannan Govindaraj,Carolina Vazquez Garzon,Jose Joaquin Velasco et al.
Kannan Govindaraj et al.
Fluorescence recovery after photobleaching (FRAP) is a widely used technique for investigating protein dynamics in live cells. FRAP enables researchers to monitor protein mobility and binding interactions in real time, providing valuable in...
Regulation of CFTR stability at the plasma membrane-Mechanisms and therapeutic opportunities in cystic fibrosis [0.03%]
囊泡膜上CFTR稳定的调节机制及在囊性纤维化中的治疗机会
Carlos M Farinha,João Oliveira
Carlos M Farinha
CFTR stability at the plasma membrane is controlled by a dynamic balance between trafficking, endocytosis, recycling, and degradation. Interactions with scaffold proteins such as NHERF1 and ezrin anchor CFTR to the actin cytoskeleton, reduc...
Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit [0.03%]
一种通过与志贺毒素B亚单位相互作用而被导入Gb3受体阳性细胞中的志贺毒素A衍生的肽的鉴定
Giulia Opassi,João C Encarnação,Valeria Napolitano et al.
Giulia Opassi et al.
Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug carriers. Using time-resolved biosensor-based assays we examined the interaction between a variety of STxA peptides (varying i...
The dual role of lectins in cancer-immunotherapy tools and therapeutic targets [0.03%]
凝集素在癌症免疫治疗工具和治疗靶点中的双重作用
Milena Dziewicka,Agnieszka Graczyk-Jarzynka
Milena Dziewicka
Altered glycosylation is a hallmark of cancer that shapes immune recognition within the tumor microenvironment. Lectins-glycan-binding proteins-play a dual role in this process: they interpret tumor-associated glycan patterns and can also b...
Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression [0.03%]
解码癌症中的动态细胞外基质——三维模型和生物支架改写肿瘤进展的规则
Sylvia Mangani,Konstantinos Spanopoulos,Zoi Piperigkou et al.
Sylvia Mangani et al.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three-dimensional cancer models more accurately reflects...
Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior [0.03%]
通过蛋白质动态和上下文依赖行为扩展经典序列-结构-功能范式
Timir Tripathi,Vladimir N Uversky,Alessandro Giuliani
Timir Tripathi
The traditional sequence-structure-function paradigm links biological activity to stable three-dimensional structures. However, growing evidence from intrinsically disordered proteins, intrinsically disordered regions, and phase-separating ...
α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates [0.03%]
α-突触核蛋白相分离及神经毒性中间体聚集路径映射研究
Silvia Arino,Giuliana Fusco,Alfonso De Simone
Silvia Arino
The aberrant aggregation of α-synuclein (αS) into insoluble amyloid fibrils is a hallmark of Parkinson's disease. Despite recent advances in characterising the properties of mature αS fibrils, the transient and heterogeneous intermediate...