The fusion of quantitative molecular proteomics and immune-oncology: a step towards precision medicine in cancer therapeutics [0.03%]
定量分子蛋白质组学与免疫肿瘤学的融合：迈向精确癌症治疗医学的第一步
James Miles,Stephen G Ward,Banafshé Larijani
James Miles
Innate and adaptive immune systems are built-in homeostatic functions of many multicellular organisms and protect the host against foreign pathogens and infections. Dysregulation of the molecular mechanisms of the immune system can result i...
A novel approach to single-cell analysis reveals intrinsic differences in immune marker expression in unstimulated BALB/c and C57BL/6 macrophages [0.03%]
一种新的单细胞分析方法揭示了未刺激的BALB/c和C57BL/6小鼠巨噬细胞中固有的免疫标志物表达差异
Jeremie Breda,Arka Banerjee,Rajesh Jayachandran et al.
Jeremie Breda et al.
The origin of functional heterogeneity among macrophages, key innate immune system components, is still debated. While mouse strains differ in their immune responses, the range of gene expression variation among their pre-stimulation macrop...
Integrin β1 transduces the signal for LY6D-induced macropinocytosis and mediates senescence-inducing stress-evoked vacuole formation via FAK [0.03%]
整合素β1转导LY6D诱导的巨胞饮信号并经FAK介导衰老引发压力下溶酶体囊泡形成
Keitaro Nakagawa,Taiki Nagano,Ryoko Katasho et al.
Keitaro Nakagawa et al.
Cellular senescence is a highly stable cell-cycle arrest induced by DNA damage and various cellular stresses. Recently, we have revealed that lymphocyte antigen 6 complex, locus D (LY6D) is responsible for senescence-inducing stress-evoked ...
Evolution of a chimeric mitochondrial carbonic anhydrase through gene fusion in a haptophyte alga [0.03%]
通过基因融合在金藻中演化出的嵌合型线粒体碳酸酐酶
Yoshihisa Hirakawa,Yutaka Hanawa,Kohei Yoneda et al.
Yoshihisa Hirakawa et al.
Carbonic anhydrases (CAs) are a universal enzyme family that catalyses the interconversion of carbon dioxide and bicarbonate, and they are localized in most compartments including mitochondria and plastids. Thus far, eight classes of CAs (...
Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors [0.03%]
核受体调控巨噬细胞胞内分解代谢的新见解
Ulrich Stifel,Giorgio Caratti,Jan Tuckermann
Ulrich Stifel
Regulation of cellular catabolic metabolism in immune cells has recently become a major concept for resolution of inflammation. Nuclear receptors (NRs), including peroxisome proliferator activator receptors, 1,25-dihydroxyvitamin D (3) rece...
Structural characterisation of a MAPR-related archaeal cytochrome b5M protein [0.03%]
与MAPR相关的古细菌cytochrome b5M蛋白的结构表征
Sarah Teakel,Michealla Marama,David Aragão et al.
Sarah Teakel et al.
We recently reported that the membrane-associated progesterone receptor (MAPR) protein family (mammalian members: PGRMC1, PGRMC2, NEUFC and NENF) originated from a new class of prokaryotic cytochrome b5 (cytb5 ) domain proteins, called cytb...
cAMP-induced decrease in cell-surface laminin receptor and cellular prion protein attenuates amyloid-β uptake and amyloid-β-induced neuronal cell death [0.03%]
环磷酸腺苷通过降低细胞表面层粘连蛋白受体和细胞内细胞朊病毒蛋白来减少对淀粉样蛋白-β的吸收及由淀粉样蛋白-β引起的神经元细胞死亡
Rayudu Gopalakrishna,Charlotte Y Lin,Andrew Oh et al.
Rayudu Gopalakrishna et al.
Previous studies have shown that amyloid-β oligomers (AβO) bind with high affinity to cellular prion protein (PrPC ). The AβO-PrPC complex binds to cell-surface co-receptors, including the laminin receptor (67LR). Our current studies rev...
The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT-20 cells in vitro [0.03%]
乳腺癌细胞中的线粒体酶FAHD1调控复盘II活性并在线性基底BT-20细胞中不可或缺
Max Holzknecht,Lena Guerrero-Navarro,Michele Petit et al.
Max Holzknecht et al.
The mitochondrial enzyme fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT-20 cells, representing th...
Loss of function of an Arabidopsis homologue of JMJD6 suppresses the dwarf phenotype of acl5, a mutant defective in thermospermine biosynthesis [0.03%]
拟南芥JMJD6同源基因失活突变体抑制acl5热柳胺生物合成缺陷突变体的矮小表型
Hirotoshi Matsuo,Hiroko Fukushima,Shinpei Kurokawa et al.
Hirotoshi Matsuo et al.
In Arabidopsis thaliana, the ACL5 gene encodes thermospermine synthase and its mutant, acl5, exhibits a dwarf phenotype with excessive xylem formation. Studies of suppressor mutants of acl5 reveal the involvement of thermospermine in enhanc...
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors [0.03%]
组合途径干扰是阐释内分泌干扰物代谢影响的强大方法
Kévin Bernal,Charbel Touma,Chedi Erradhouani et al.
Kévin Bernal et al.
The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have r...