NONO promotes MYB expression and splicing by interacting with enhancer lncRNA MY34UE-AS in human leukemia cells [0.03%]
NONO通过与MY34UE-AS互作促进人白血病细胞中MYB的表达和剪接
Siyu Shen,Yucheng Wang,Xiaoxiao Tao et al.
Siyu Shen et al.
Dysregulation of the transcription factor MYB plays a critical role in leukemia pathogenesis, progression, and prognosis; however, the detailed regulatory mechanisms of MYB remain unclear. Recently, we identified an enhancer long noncoding ...
Gut microbiome and aging-A dynamic interplay of microbes, metabolites, and the immune system [0.03%]
肠道微生物组与衰老-微生物、代谢物和免疫系统之间的动态相互作用
Aaron Mehl,Eran Blacher
Aaron Mehl
Aging is accompanied by profound changes in both the gut microbiome and the immune system, which engage in continuous, bidirectional communication. Alterations in microbial diversity and metabolism, particularly reductions in short-chain fa...
Tau acetylation at K331 has limited impact on tau pathology in vivo [0.03%]
组蛋白乙酰转移酶p300介导的tau K331位点乙酰化在体内外对tau病理的影响有限
Shoko Hashimoto,Yukio Matsuba,Mika Takahashi et al.
Shoko Hashimoto et al.
Post-translational modifications regulate tau aggregation and propagation, yet how amyloid pathology shapes the tau modification landscape remains unclear. Using liquid chromatography-tandem mass spectrometry, we compared tau modifications ...
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties [0.03%]
具有改良的MHET降解性质的工程杨梅素酯酶的结构洞察
Panagiota Karampa,Konstantinos Makryniotis,Theofani-Iosifina Sousani et al.
Panagiota Karampa et al.
Mono(2-hydroxyethyl) terephthalate (MHET) esterases (MHETases) are enzymes implicated in polyethylene terephthalate (PET) biodegradation. The present study elucidates the structural determinants that result in increased MHET degradation by ...
The planar cell polarity protein Vangl2 interacts with the PDZ-domains of Scribble but not with a unique PDZ-like domain in Inturned [0.03%]
平面多极性蛋白vangl2与scribble的pdz结构域而非inturned的独特pdz样结构域相互作用
Stephan Wilmes,Jan Brysch,Carmen Gelze et al.
Stephan Wilmes et al.
The proteins Inturned and Fuzzy are members of the tri-longin domain (TLD) RabGEF family and activate the GTPase Rab23 downstream of the core planar cell polarity (PCP) proteins Vangl2 and Prickle. To gain insight into the function of a pre...
Calpain small subunit homodimerization is robust and calcium-independent [0.03%]
钙蛋白酶小亚基同二聚化稳定且不受钙离子影响
Nesha May O Andoy,Trina Dykstra-MacPherson,Mathias A Bell et al.
Nesha May O Andoy et al.
Calpains dimerize via penta-EF-hand (PEF) domains, but their mechanical stability and kinetics remain incompletely characterized. Here, we used single-molecule force spectroscopy on an EGFP-tagged calpain small subunit PEF (CAPNS1-PEF) homo...
The crystal structure of the TPR domain of the EccA5 ATPase and demonstration of its interaction with EspG5 from the mycobacterial ESX-5 pathway [0.03%]
EccA5 ATP酶的TPR结构域晶体结构及其与结核分枝杆菌ESX-5途径EspG5蛋白的相互作用研究
Vijay Kumar Sharma,Jyoti Vishwakarma,Rajlakshmi Kabrambam et al.
Vijay Kumar Sharma et al.
The ESX-5 secretion system in Mycobacterium tuberculosis exports PE/PPE virulence factors, with EccA5, an AAA+ ATPase, playing a pivotal role. We solved the crystal structure of EccA5's N-terminal TPR domain (EccA5NT) at 2.15 Å, revealing ...
Transferrin receptor 1-mediated iron uptake supports thermogenic activation in human cervical-derived adipocytes [0.03%]
人宫颈来源的脂肪细胞中转铁蛋白受体1介导的铁摄取支持产热活化
Rahaf Alrifai,Mizuki Seo,Gyath Karadsheh et al.
Rahaf Alrifai et al.
Adrenergic-driven thermogenic activation of brown adipose tissue requires high amounts of nutrients including iron to support mitochondrial biogenesis. This is governed by rapid gene expression changes in ex vivo differentiated human cervic...
Disrupted STIL-BRCA1 axis causes centrosome amplification and genomic instability [0.03%]
STIL-BRCA1轴紊乱导致中心体扩增和基因组不稳定
Srishti Sanghi,Mahima Joshi,Priyanka Singh
Srishti Sanghi
Centrosome abnormalities can lead to erroneous chromosome segregation during cell division, resulting in genomic instability. We identified a cancer-associated heterozygous missense mutation (S76L) in the centrosome protein STIL that promot...
TNFR2 signaling promotes monocytic-MDSC differentiation and production of immunosuppressive mediators [0.03%]
TNFR2信号转导促进单核细胞来源的抑制细胞分化及免疫抑制介质产生
Yuta Tsuji,Masaki Inoue,Tomoya Okuda et al.
Yuta Tsuji et al.
Myeloid-derived suppressor cells (MDSCs) differentiate and proliferate in the pathological context of cancer, suppress T-cell responses, and promote tumor progression and therapeutic resistance. These cells express high levels of TNF recept...