A deep dive into spin-labeled polysorbate's interaction with therapeutic antibody using 2D NMR, EPR and MD simulations [0.03%]
基于二维NMR、EPR及MD模拟的润湿剂多硫酸酯类小分子与治疗性抗体的作用研究
Blaž Lebar,Maria Orehova,Boštjan Japelj et al.
Blaž Lebar et al.
Polysorbates (PS) are widely used surfactants in biopharmaceutical formulations playing a crucial role in protecting proteins against mechanical stress and interface-induced damage. However, their susceptibility to degradation can compromis...
A SpyCatcher-assembled mannosylated nanovaccine elicits potent and cross-protective immunity against monkeypox virus [0.03%]
一种用于灵长类天花病毒的甘露糖修饰纳米疫苗诱导强有力的交叉保护性免疫响应
Wenying Yan,Lijuan Shen,Jinming Qi et al.
Wenying Yan et al.
Monkeypox (mpox), caused by the monkeypox virus (MPXV), is a zoonotic disease of global public health concern. Current live-attenuated vaccines suffer from safety concerns and unsatisfactory protection effectiveness. To address these limita...
Development and application of a novel tracer system for the evaluation of temperature exposure of lipid nanoparticles in spray drying and dual centrifugation [0.03%]
一种新型示踪系统的发展和应用，用于评估喷雾干燥和双重离心过程中脂质纳米颗粒的温度暴露情况
Isabelle Klein,Denise Steiner
Isabelle Klein
In recent years, the development of nanocarriers and nanoscale drug delivery systems has become increasingly important, with temperature-intensive processes being an essential part of their preparation and following process steps. This stud...
Design-of-experiments based development and in vitro evaluation of a cationic lipid-based triple adjuvanted subunit pertussis vaccine [0.03%]
基于实验设计的阳离子脂质三佐剂亚单位百日咳疫苗的开发和体外评价
Tavonga T Mandava,Volker Gerdts,Maryam Ejlali et al.
Tavonga T Mandava et al.
The use of a cationic lipid nanoparticle based triple adjuvant complex (L-TriAdj) was previously demonstrated to provide great utility in enhancing local intranasal immunity against pertussis. However, the role of lipid composition as a cri...
Degradable glycyrrhetinic acid functionalized mesoporous silica nanoparticles enhanced liver cancer therapy [0.03%]
甘草酸功能化介孔硅纳米颗粒增强肝癌治疗效果
Zhenhua Li,Junjie Zhang,Chuanyong Fan et al.
Zhenhua Li et al.
The study aimed to design a drug delivery system (DDS) with smart responsiveness in the tumor microenvironment (TME). Herein, manganese-doped mesoporous silica nanoparticles with glycyrrhetinic acid (GA) on their surface (MMSN-GA) were cons...
Polystyrene beads for efficient temperature control and drug nanoparticle production in wet stirred media milling [0.03%]
聚苯乙烯珠在湿式搅拌介质磨削中的高效控温和药物纳米粒子制备中的应用
Hamidreza Heidari,Wren McAleer,Gulenay Guner et al.
Hamidreza Heidari et al.
This study explores the effects of stirrer speed, bead loading, and bead size on the evolution of mill outlet temperature during the wet stirred media milling (WSMM) of fenofibrate suspensions using crosslinked polystyrene (CPS) beads. Key ...
About the impact of hydrophilic organic solvents on the emulsifying properties of self-emulsifying drug delivery systems (SEDDS) [0.03%]
关于亲水性有机溶剂对自乳化药物递送系统( SEDDS )乳化性能影响的研究
Ahmad Saleh,Khush Bakhat Afzal,Florina Veider et al.
Ahmad Saleh et al.
This study presents the first comprehensive evidence that hydrophilic organic solvents markedly accelerate SEDDS emulsification under biorelevant conditions, while maintaining both stability and safety. These findings establish their critic...
Poly(vinyl alcohol) cryogels: Effect size of polymer concentration, number of cycles and thawing rate on material properties and dermal drug delivery [0.03%]
聚乙烯醇冻凝胶：聚合物浓度、循环次数和解冻速率对材料性能和皮肤药物传递的影响大小
Y Wiedemann,T Schmitt,S Kim et al.
Y Wiedemann et al.
Poly(vinyl alcohol) (PVA) can be physically cross-linked by repeated freeze-thaw (F-T) cycles, resulting in a cryogel. Despite the growing prevalence of the cryogelation process in the scientific literature, its multivariable nature, partic...
Rutin/ZnO/mesoporous Silica-based Nano-hydrogel accelerated topical wound healing in albino mice via potential synergistic bioactive response [0.03%]
茋/氧化锌/介孔硅纳米水凝胶通过潜在的协同活性响应加速白化小鼠创面修复
Huma Butt,Haji Muhammad Shoaib Khan,Muhammad Sohail et al.
Huma Butt et al.
Burn wounds are the leading cause of accidental topical injuries. To avoid the chances of delayed healing and microbial infiltration, treating the wound with a potent antimicrobial and anti-inflammatory topical formulation is mandatory. The...
Development of in vitro-in vivo correlation for establishing patient-centric quality standards of dissolution for lamotrigine extended-release tablets [0.03%]
用于开发拉莫三嗪缓释片的以患者为中心的溶出质量标准的体内体外相关性研究的发展
Ahmed Zidan,Abu Bakar Siddique,Maha Shaklah et al.
Ahmed Zidan et al.
In vitro-in vivo correlation (IVIVC) studies have been commonly used for assessing the impact of formulation and manufacturing changes on drug performance. The current study developed an IVIVC to establish patient-centric quality standards ...