Pharmacomagnetography of floating gastroretentive systems in vivo in different prandial states evaluated by AC biosusceptometry [0.03%]
以空腹和餐后状态评估浮置胃滞留系统的体内药剂磁图——交流生物磁导率法
Gustavo Serafim Rodrigues,Laís Pereira Buranello,João Miguel Barboza et al.
Gustavo Serafim Rodrigues et al.
In recent decades, the development of effective therapies with minimal adverse effects has become a major challenge in the pharmaceutical field. Despite its popularity, oral administration faces limitations related to the physiological vari...
Synergistic co-processing of heat-moisture treated resistant rice starch with HPMC and Eudragit® S100: A novel multifunctional excipient for direct compression and colon-targeted delivery [0.03%]
热湿处理抗性稻淀粉与羟丙基甲基纤维素和伊维拉GIT骨架材料的协同共处理：直接压缩和结肠靶向输送的新型多功能辅料
Karnkamol Trisopon,Phennapha Saokham,Nisit Kittipongpatana et al.
Karnkamol Trisopon et al.
A novel multifunctional excipient was developed based on co-processed resistant rice starch (RRS) for direct compression (DC) tablet and targeted colonic drug delivery. While rice starch (RS) is biodegradable and exhibits good compressibili...
Analysis of discrepancy in SNEDDS performance for a "brick dust" mebendazole between in and vitro and in-vivo estimation [0.03%]
基于“砖尘”美倍茨的SNEDDS性能的体内体外评估差异分析
Seito Maehara,Saki Nishiyama,Masato Maruyama et al.
Seito Maehara et al.
Oral absorption of mebendazole (MBZ), a brick dust, was successfully improved 10 times by dosing 2 % HPMCP-50 SNEDDS of MBZ co-amorphized with (+)-10-camphorsulufonic acid (CSA) (MBZ-CSA), compared with crystal powders in our previous study...
Nanoparticle-based oral rinses for plaque control: A systematic review of efficacy and safety [0.03%]
基于纳米颗粒的控制牙菌斑的漱口水：功效和安全性的系统评价研究
Bakr Ahmed,Fatima Ahmed,Anil Kumar et al.
Bakr Ahmed et al.
This systematic review analyzes clinical, preclinical, and patent literature on nano-enabled mouthwashes for plaque control. Searches were conducted across PubMed, Embase, Scopus, Web of Science, and three patent databases (Google Patents, ...
Optimization of intranasal trifluoperazine/SPION-leciplex thermosensitive organogel for depression therapy: Pharmacodynamic and pharmacokinetic comparison of magnet placement effects on brain versus nose [0.03%]
用于抑郁症治疗的鼻内三氟拉嗪/SPION-leciplex热敏有机凝胶的优化：脑与鼻磁铁放置对药动学和药效学影响的比较
Soha Elsalhy,Hanan Refai,Dina A Osman et al.
Soha Elsalhy et al.
Trifluoperazine (TFP), an antipsychotic used in depression management, suffers from extensive first-pass metabolism and poor oral bioavailability. Intranasal delivery offers a promising non-invasive route for direct nose-to-brain targeting,...
Development of Trastuzumab-coupled, siRNA encapsulating mPolyplexes targeting HER2 overexpressing cancer cells [0.03%]
一种针对HER2高表达癌细胞的曲妥珠单抗偶联siRNA载药m聚子体系的开发研究
Joschka T Müller,Salvatore Caruso,Anny Nguyen et al.
Joschka T Müller et al.
Over the past decades, significant advancements have been made in various medical fields; however, ovarian cancer (OC) remains inadequately addressed, predominantly relying on relatively toxic cytostatic treatments. In this study, we applie...
Development of media simulating the properties of human peritoneal fluid and verification of its bio-relevance [0.03%]
仿人腹膜液性质的介质开发及其生物相容性验证研究
Magdy M Abdelquader,Shu Li,Gavin P Andrews et al.
Magdy M Abdelquader et al.
Intraperitoneal drug delivery offers a promising strategy for localized treatment of peritoneal tumours and post-surgical wound care. To control drug release profiles, drugs are often embedded within peritoneal implants or delivery devices....
Mucus-penetrating archaeolipid nanocarriers delivering Thymus vulgaris essential oil and tobramycin: A multifunctional approach against Pseudomonas aeruginosa biofilms and inflammation [0.03%]
递送迷迭香精油和妥布霉素的黏液穿透型古脂质纳米载体：一种对抗绿脓杆菌生物膜和炎症的多功能方法
Noelia Perez,Milagros Velurtas,Patricia C Rivas Rojas et al.
Noelia Perez et al.
Cystic fibrosis (CF) is characterized by thick mucus obstruction, persistent Pseudomonas aeruginosa biofilms, and chronic airway inflammation, leading to progressive lung damage. Inhaled tobramycin (TB) is the standard antibiotic therapy bu...
Self-assembled rapamycin prodrug nanoparticles for posterior segment targeting and effective treatment of experimental uveitis [0.03%]
自组装西罗莫司前药纳米粒靶向眼后段及有效治疗实验性葡萄膜炎
Fangming Liang,Yue Wang,Ning Li et al.
Fangming Liang et al.
The treatment of posterior uveitis remains challenging due to the need for long-term medication and the limited efficacy of current therapies. In this study, we developed an injectable rapamycin-based nanoparticle formulation designed to ex...
Corrigendum to "Dissolving microneedle patches for delivery of amniotic mesenchymal stem cell metabolite products for skin regeneration in UV-aging induced mice" [Eur. J. Pharm. Biopharm. 204 (2024) 114482] [0.03%]
关于“用于紫外线老化诱导小鼠皮肤再生的透明质干细胞代谢产物递送的溶解微针贴片”的勘误修正[Eur. J. Pharm. Biopharm. 204 (2024) 114482]
Andang Miatmoko,Berlian Sarasitha Hariawan,Devy Maulidya Cahyani et al.
Andang Miatmoko et al.