Effects of Co-Processed and conventional excipients on content uniformity [0.03%]
共处理和常规辅料对片剂含量均匀度的影响考察
Stephanie Stewart,Jenna Reinhard,Anthony Carpanzano et al.
Stephanie Stewart et al.
Silicification of microcrystalline cellulose (MCC) has previously been shown to have positive effects on the powder's flowability and tabletability compared to plain MCC or physical blends of colloidal silicon dioxide (CSD) and MCC [1]. A f...
Improving prefilled syringe injectability: influences of critical component attributes and human factors [0.03%]
预填充注射器给药性能的改善：关键组件属性和人机工学因素的影响
Yunyun Wang,Hui Li,Linke Wu et al.
Yunyun Wang et al.
Prefilled syringes (PFSs) have emerged as a predominant primary packaging format for subcutaneous biopharmaceutical drug products. Subcutaneous administration typically requires low injection volumes and high drug concentrations, which freq...
Inhalable nanocapsules for lung delivery of Pirfenidone and Bacterioruberin: Modulating macrophages to target pulmonary fibrosis [0.03%]
用于肺纤维化治疗的吸入式纳米囊泡递送吡非尼酮和嗜盐古菌紫素：通过调节巨噬细胞发挥作用
Micaela Ailén Juncal,Ezequiel Nicolás Caputo,Patricia Carolina Rivas Rojas et al.
Micaela Ailén Juncal et al.
In this work, we developed an inhalable polymeric-lipid nanocapsule formulation with mucus-penetrating properties to co-encapsulate Pirfenidone (Pfd) and the carotenoid Bacterioruberin (BR), aiming to enhance anti-inflammatory, antioxidant,...
Recent advances in peptide-based self-assembled and metal coordinated nanocarriers for targeted cancer drug delivery [0.03%]
基于肽的自组装和金属配位纳米载体在癌症药物靶向递送中的最新进展
Vijay Bhooshan Kumar
Vijay Bhooshan Kumar
Despite significant progress in anti-cancer therapies, major challenges persist, such as cytotoxicity, drug resistance, and lack of specificity toward tumour tissues. In recent years, peptide self-assembly has emerged as a powerful strategy...
Tungsten residues in prefilled syringes promote monoclonal antibody aggregation and charge heterogeneity [0.03%]
预填充注射器中的钨残留物可促进单克隆抗体聚集和电荷异质性
Chao-Yang Du,Min Zou,Zi-Ting Xu et al.
Chao-Yang Du et al.
Monoclonal antibodies (mAbs) are pivotal therapeutics; however, their stability during production and storage remains a critical challenge, particularly in prefilled syringes (PFS), where tungsten residues from manufacturing can compromise ...
Tuna Collagen-Based hydrogels for the targeted delivery of BET inhibitors and BET-PROTACs in breast cancer therapy [0.03%]
基于金枪鱼胶原蛋白的水凝胶在乳腺癌治疗中用于BET抑制剂和BET-PROTACs的靶向递送
Irene Sevilla-Carrillo,Carolina Hermida-Merino,Inmaculada Posadas et al.
Irene Sevilla-Carrillo et al.
Targeted protein degradation (TPD) strategies, including BET inhibitors and PROTACs, offer a promising approach for cancer therapy by selectively degrading disease-relevant proteins. However, their clinical translation is hindered by poor s...
Thermal analysis of magnetic nanoparticles in laryngeal cancer hyperthermia using computational simulation [0.03%]
基于计算模拟的声门部癌症磁热疗中磁性纳米颗粒的热分析
Kazhal Moetamedi,Mohammad Hossein Tavakoli,Zahra Keshtpour Amlashi et al.
Kazhal Moetamedi et al.
Hyperthermia is a cancer treatment method that applies controlled heat to target and destroy cancer cells. Hyperthermia raises tumor temperatures to 42-46 °C, selectively damaging cancer cells while sparing healthy tissues. In this study, ...
Corrigendum to: Film-forming system of optimized tacrolimus-loaded nanostructured lipid carriers for effective topical treatment of atopic dermatitis (European Journal of Pharmaceutics and Biopharmaceutics, volume 216, article number 114871) [0.03%]
Correction to: 优化他克莫司载药纳米结构脂质载体的成膜系统以有效治疗特应性皮炎（欧洲药物科学与生物药物学杂志，第216卷，文章编号114871）
Jin Sil Kang,Young-Guk Na,Minki Jin et al.
Jin Sil Kang et al.
A pivotal, dermal, in-vivo bioequivalence study performed by confocal Raman spectroscopy (CRS) [0.03%]
一项 pivotal 研究：利用共焦拉曼光谱(CRS)进行的皮肤体内生物等效性研究
J Link,C Heusel,D J Lunter
J Link
The EMA guideline on quality and equivalence of locally applied, locally acting cutaneous products, endorses the use of the stratum corneum (SC) sampling technique (Tape Stripping, TS) in lieu of an expensive and resource-intensive clinical...
A deep dive into spin-labeled polysorbate's interaction with therapeutic antibody using 2D NMR, EPR and MD simulations [0.03%]
基于二维NMR、EPR及MD模拟的润湿剂多硫酸酯类小分子与治疗性抗体的作用研究
Blaž Lebar,Maria Orehova,Boštjan Japelj et al.
Blaž Lebar et al.
Polysorbates (PS) are widely used surfactants in biopharmaceutical formulations playing a crucial role in protecting proteins against mechanical stress and interface-induced damage. However, their susceptibility to degradation can compromis...