Reflection paper on the APV workshop on in vitro performance testing of topically applied and topically acting substances [0.03%]
关于APV体外测试工作组工作会议的反思论文
Dominique Lunter,Sascha Gorissen,Michael Herbig et al.
Dominique Lunter et al.
With great anticipation, the European Medicines Agency (EMA) guideline titled "Quality and Equivalence of Locally Applied, Locally Acting Cutaneous Products" officially came into effect on April 2, 2025. This regulatory document establishes...
Exploration of a dual-mimetic mucus inert nanocomplex for enhanced oral insulin delivery [0.03%]
用于增强口服胰岛素递送的双模拟黏液惰性纳米复合物的研究
Qiyao Zhai,Shuang Guo,Zhixiang Cui et al.
Qiyao Zhai et al.
The development of oral insulin delivery systems has advanced significantly, with polyelectrolyte nanocomplexes (PEC) showing promise due to their solvent-free synthesis. However, their efficacy is limited by poor mucus penetration and inte...
Novel PLA-based shape-memory formulation: Design, preparation, and evaluation for gastro-retentive delivery of 5-fluorouracil to enhance oral bioavailability [0.03%]
一种新型PLA基形状记忆材料的设计、制备及评价：用于提高口服生物利用度的5-氟尿嘧啶胃滞留输送系统
Fengxue Liu,Xuefei Yu,Yanmei Wu et al.
Fengxue Liu et al.
5-fluorouracil (5-FU) is one of the most effective chemotherapeutic drugs for various solid tumors. However, its low water solubility and limited absorption rates in the stomach are crucial limitations that prevent it from being effectively...
Understanding peroxide formation in Tween® 80 using RapidOxy®: Implications for pharmaceutical nanoemulsions [0.03%]
利用RapidOxy®理解Tween® 80中的过氧化物形成及其对制药纳米乳液的影响
Anna Fedorko,Carolin Tetyczka,Jesús Alberto Afonso Urich
Anna Fedorko
The oxidation stability of Tween® 80, a widely used surfactant in pharmaceutical formulations, was analyzed in-depth to predict its shelf life under pharmaceutical stability conditions. This study aimed to determine the influence of oxidat...
Development of spray-dried phage-aztreonam microparticles for inhalation therapy of Pseudomonas aeruginosa lung infections [0.03%]
开发用于铜绿假单胞菌肺部感染吸入治疗的喷雾干燥噬菌体-阿维斯汀微粒
Alexandra Hübl,Johannes Most,Christopher Hauß et al.
Alexandra Hübl et al.
Despite considerable efforts in antibiotic therapy, pulmonary infections caused by Pseudomonas aeruginosa remain a major challenge, particularly in diseases such as cystic fibrosis. Bacteriophage-antibiotic combinations have recently emerge...
3D-printing of lipid formulations: Going slow in a fast-paced field [0.03%]
脂质体制剂的3D打印：在快速发展的领域中稳步前进
Moaaz Abdelhamid,Dalip Kumar,Martin Spoerk et al.
Moaaz Abdelhamid et al.
Lipid-based excipients (LBE) are a crucial class of functional excipients with significant potential for pharmaceutical formulation and product development. The wide variety of molecules in this class provides opportunities for designing no...
A biomimetic nano-suspension based on orthoester designed for the inhibition of postoperative tumor recurrence [0.03%]
一种基于邻酯的仿生纳米悬浮液用于术后抗肿瘤复发研究
Rongjian Hu,Xian Zhang,Weibin Shao et al.
Rongjian Hu et al.
Tumor recurrence after surgery remains a major challenge. Herein, an orthoester (OE) compound was synthesized as a liquid pharmaceutical excipient. Next, an injectable suspension loaded with biomimetic nanoparticles and photothermal agents ...
Co-delivery of dolutegravir and carbon-nanoparticles using niosomal platform for enhanced anti-HIV and pharmacokinetic activity [0.03%]
使用尼油体平台共输送多替拉韦和碳纳米颗粒以增强抗艾滋病病毒和药代动力学活性
Kaushiki Ash,R Harshithkumar,Madhuri Chandane-Tak et al.
Kaushiki Ash et al.
The present study investigates the comparative evaluation of DTG-P, DTG-N and C-Np-DTG-N against HIV-1 infection. C-Np were synthesized from Buchanania lanzan leaves using a microwave-assisted method. The DTG-N formulation was optimized usi...
Nanogel therapy for chronic and post-surgical wounds: a bioengineered Lactoferrin-Acacia-Alginate system enhancing tissue regeneration and inflammatory resolution [0.03%]
用于慢性伤口和术后伤口的纳米凝胶疗法：一种促进组织再生和炎症消退的乳铁蛋白-刺槐豆 gum-海藻酸生物工程体系
Samaa Abdullah,Samar Thiab,Abeer A Altamimi et al.
Samaa Abdullah et al.
Chronic and post-surgical wounds often exhibit poor angiogenesis, persistent inflammation, and delayed tissue remodeling. Lactoferrin (LAC), a multifunctional glycoprotein with immunomodulatory and healing properties, faces challenges like ...
Utilizing the dynamic gastrointestinal model (DGM) to evaluate the gastric integrity of Capsugel® Enprotect® capsules in fasted and fed states [0.03%]
利用动态胃肠道模型评估空腹和餐后状态下Capsugel® Enprotect®硬胶囊的胃内完整性的评价
Matthias Manne Knopp,Vincent Jannin,Vanessa Gonzalez et al.
Matthias Manne Knopp et al.
This study aimed to evaluate if the Dynamic Gastrointestinal Model (DGM) is able to simulate the gastro-resistant behavior of Capsugel® Enprotect® capsules under physiologically relevant fasted and fed conditions. Enprotect® capsules wer...