A new drug-drug co-amorphous system of imipramine and celecoxib with improved solubility and synergistic antinociceptive effects [0.03%]
一种伊马普明和塞来昔布协同增效的新型药物共无定形体系：改善溶解度及协同镇痛作用
Zhiling Chen,Huiling Zhou,Jie Song et al.
Zhiling Chen et al.
Because the monotherapy of currently available pain killers often shows serious adverse effects or limited efficacy for treating neuropathic pain, multimodal analgesia has been highly recommended to gain improved antinociceptive effects and...
Rifampicin-containing interpenetrating hydrogel networks (IHNs) based on poly(methacrylates) and Poloxamers, and their potential as short-duration use antimicrobial medical device biomaterials [0.03%]
基于聚甲基丙烯酸酯和普拉洛泊的利福平共连续水凝胶网络及其作为短效抗菌医疗器械材料的潜力
David S Jones,M Westwood,S Li et al.
David S Jones et al.
This study describes the surface, mechanical, swelling, microbial anti-adherence and drug release properties of rifampicin-containing interpenetrating hydrogel networks (IHNs) composed of either poly(hydroxyethylmethacrylate, p(HEMA)) or po...
Enhancing bioavailability of a weakly basic drug through cocrystallization: PBPK modeling of ketoconazole-succinic acid [0.03%]
通过共晶化提高弱碱性药物生物利用度：酮康唑-琥珀酸的PBPK建模研究
Ana Karolina Santos Goes,Amira Soliman,Venkata Krishna Kowthavarpu et al.
Ana Karolina Santos Goes et al.
Pharmaceutical cocrystals, formed by combining an active pharmaceutical ingredient (API) with a suitable coformer, offer a promising strategy to enhance drug solubility, stability, and dissolution, thereby improving absorption and bioavaila...
Factors affecting flash nanoprecipitation of Pharmaceuticals: Principles and applications [0.03%]
药物飞射纳米沉淀法影响因素：原理及应用
Wisdom Awuku,Bi-Botti Celestin Youan
Wisdom Awuku
Flash nanoprecipitation (FNP) has emerged as a transformative technique in the preparation of nanoparticles for targeted drug delivery. Traditional drug delivery systems often struggle with challenges such as poor solubility, limited bioava...
Novel drug-drug cocrystal form of Luteolin with Metformin: Improved solubility, bioavailability, and in vitro anticancer activity [0.03%]
一种新型药物共晶形式：与二甲双胍结合的芹菜素具有改善溶解性、生物利用度和体外抗癌活性
Ningrong Wang,Jianing Zhao,Yiwu Wang et al.
Ningrong Wang et al.
Due to the extremely low water solubility, poor oral bioavailability, and limited monotherapeutic efficacy of Luteolin (Lut), its clinical application is severely restricted. To overcome these limitations, this study successfully synthesize...
Tuning the in vivo transfection efficiency of mRNA-Loaded lipoplexes by PEG-Lipid structure and ratio [0.03%]
通过PEG脂质结构和比例调节载有mRNA的lipoplexes的体内转染效率
Markov O V,Antropov D N,Shmendel E V et al.
Markov O V et al.
The development of mRNA-based antiviral and antitumor therapeutics is progressing rapidly and shows considerable promise. Optimizing the composition of liposomal delivery vehicles is critical for enhancing mRNA vaccine efficacy. Among their...
Humectant-plasticized poly(vinyl alcohol)-sericin hydrogels with improved dimensional stability and moisture retention for wound dressing applications [0.03%]
一种用于伤口敷料的保湿增塑型聚乙烯醇-丝素蛋白水凝胶及其制备方法与应用
Thunyaluk Meetam,Rungnapha Yamdech,Pithi Chanvorachote et al.
Thunyaluk Meetam et al.
This study investigated the development of poly(vinyl alcohol) (PVA)/sericin hydrogels incorporating humectant-plasticizers glycerin, propylene glycol, and mannitol for wound dressing applications. Although PVA/sericin hydrogels exhibit exc...
Corrigendum to "Nanogel therapy for chronic and post-surgical wounds: a bioengineered Lactoferrin-Acacia-Alginate system enhancing tissue regeneration and inflammatory resolution" [Eur. J. Pharm. Biopharm. 219 (2026) 114952] [0.03%]
关于“用于慢性术后伤口的纳米凝胶疗法：一种促进组织再生和炎症消退的乳铁蛋白-阿拉伯胶-海藻酸生物工程系统”的勘误说明
Samaa Abdullah,Samar Thiab,Abeer A Altamimi et al.
Samaa Abdullah et al.
Co-administering clofazimine with infant formula enhances its oral bioavailability in rats and pigs [0.03%]
与婴儿配方奶粉联用克洛沙锌可提高其口服生物利用度（大鼠和猪模型）
Thomas Eason,Ellie Ponsonby-Thomas,Anna C Pham et al.
Thomas Eason et al.
Milk-based formulations have been proposed as enabling formulations for the delivery of poorly water-soluble drugs to children due to their safety, versatility in dose control and ability to improve drug solubilisation through the digestion...
Sulfasalazine-quercetin co-amorphous systems: Sustained release behaviors and enhanced pharmacokinetics [0.03%]
磺胺吡唑啉-檞皮素共无定形系统：长效释放行为及药动学增强效应
Jia Deng,Jiangying Li,Yangwen Peng et al.
Jia Deng et al.
Sulfasalazine (SULF) is a well-established therapeutic agent for rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), but its oral absorption is limited by efflux transporters, particularly MRP2 and BCRP. Consequently, high daily...