Co-formulations of adalimumab with hyaluronic acid/polyvinylpyrrolidone to combine intraarticular drug delivery and viscosupplementation [0.03%]
一种阿达利姆单抗与透明质酸/聚乙烯吡咯烷酮的共配方以结合关节内药物递送和润滑补充作用
Tobias Siefen,Simon Bjerregaard,Daniel Plaksin et al.
Tobias Siefen et al.
Polymer-based formulations present an attractive strategy in intraarticular drug-delivery to refrain biologicals from early leakage from the joint. In this study, co-formulations of hyaluronic acid and polyvinylpyrrolidone were investigated...
Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release [0.03%]
刺激响应型诊疗系统：增强多模态成像和高效药物释放的有前途的方法
Ayşegül Demiral,S İrem Goralı,Hülya Yılmaz et al.
Ayşegül Demiral et al.
Destruction of drug resistant and invisible micro-tumors requires innovative screening and treatment modalities. Theranostic nanosystems offering multimodal imaging and therapy are attractive platforms with potential to make micro-tumors vi...
Topical liquid formulation of bacteriophages for metered-dose spray delivery [0.03%]
用于定量喷雾给药的噬菌体液体制剂
Rachel Yoon Kyung Chang,Yuko Okamoto,Sandra Morales et al.
Rachel Yoon Kyung Chang et al.
Bacteriophage (phage) therapy is a promising treatment strategy to combat antibiotic-resistant bacteria. Clinical reports from a century ago, as well as recent reports have revealed safety and efficacy of phage therapy for bacterial wound i...
A biotin-modified and H2O2-activatable theranostic nanoplatform for enhanced photothermal and chemical combination cancer therapy [0.03%]
一种生物素修饰和H2O2激活的可诊断及治疗纳米平台用于增强型光热及化学协同癌症治疗
Chuanjiang Jian,Ying Wang,Huijun Liu et al.
Chuanjiang Jian et al.
Although synergistic effects of photothermal therapy (PTT) and chemotherapy for cancer have been extensively investigated in previous studies, more potential strategies need to be exploited to alleviate severe adverse effects. In this study...
PLGA implants for controlled drug release: Impact of the diameter [0.03%]
聚乳酸-乙醇酸缓释制剂的体外释放特征及其影响因素研究
C Bassand,J Freitag,L Benabed et al.
C Bassand et al.
The aim of this study was to better understand the importance of the diameter of poly(lactic-co-glycolic acid) (PLGA)-based implants on system performance, in particular the control of drug release. Different types of ibuprofen-loaded impla...
Comparing extracellular vesicles and cell membranes as biocompatible coatings for gold nanorods: Implications for targeted theranostics [0.03%]
外泌体和细胞膜作为金纳米棒生物相容性涂层的比较：靶向诊疗中的意义
Paula Maria Pincela Lins,Laís Ribovski,Luana Corsi Antonio et al.
Paula Maria Pincela Lins et al.
Extracellular vesicles (EVs) and cell membrane nanoghosts are excellent coatings for nanomaterials, providing enhanced delivery in the target sites and evasion of the immune system. These cell-derived coatings allow the exploration of the d...
Simplified choice of suitable excipients within biologics formulation design using protein-protein interaction- and water activity-maps [0.03%]
基于蛋白质相互作用和物料平衡的图谱简化生物药制剂辅料选择的方法研究
Tanja Stolzke,Christoph Brandenbusch
Tanja Stolzke
Still today, high-concentration protein formulations are often developed based on high-throughput experimental screening approaches. Although likely delivering working formulations, these approaches do not lead to a deep/mechanistic underst...
Long chain triglyceride-lipid formulation promotes the oral absorption of the lipidic prodrugs through coincident intestinal behaviors [0.03%]
长链三酰基甘油脂质体制剂通过肠道内同时发生的行为促进脂溶性前药的口服吸收
Chu-Tong Tian,Jing-Jing Guo,Yi-Fan Miao et al.
Chu-Tong Tian et al.
Oral administration of chemotherapy agents, such as docetaxel (DTX), is expected to reduce side effects significantly and increase dosing frequency. However, they often suffer from poor oral bioavailability, impeding their oral application....
Single versus double occupancy solid lipid nanoparticles for delivery of the dual-acting bacteriocin, lacticin 3147 [0.03%]
单 occupancy 和双 occupancy 固体脂质纳米颗粒递送双作用细菌素 lactococcin 3147 的研究
Aoibhín Ryan,Pratikkumar Patel,Paula M O&#x;Connor et al.
Aoibhín Ryan et al.
The bacteriocin lacticin 3147 (lacticin) has shown activity against clinically relevant and antimicrobial-resistant bacteria such as Listeria monocytogenes and Clostridioides difficile. It is composed of two peptides, Ltnα and Ltnβ, which...
High doses of graphene quantum dots impacts on microcirculation system: An observational study [0.03%]
高剂量的石墨烯量子点对微循环系统影响的观察性研究
Aline Oliveira da Silva Barros,Eduardo Ricci-Junior,Jonathas Xavier Pereira et al.
Aline Oliveira da Silva Barros et al.
Graphene and its derivatives are in the edge of technology with a wide and diverse range of applications. In the last years, especially graphene quantum dots (GQDs) have had their biomedical application expanded in scope, mainly focused on ...