Thermosensitive chitosan-oxidized dextran-β-glycerophosphate sodium injectable hydrogel for enhanced solubility and prolonged release of ethinylestradiol: a novel long-acting contraceptive platform [0.03%]
一种用于提高左旋炔雌醚溶解度和长效释放的热敏性壳聚糖-氧化葡聚糖-β-甘油磷酸钠注射液水凝胶：一种新型长效避孕平台
Xuena Zhang,Fengqiang Zhang,Chongwei Yin et al.
Xuena Zhang et al.
Ethinylestradiol (EE) is a clinically used estrogen with antifertility effects that is poorly water soluble, limiting bioavailability and preventing long-term release when administered orally. This study addresses these challenges through t...
Structural insights into novel coamorphous systems of azithromycin with faster dissolution profile [0.03%]
具有更快溶出曲线的阿奇霉素新型共无定形系统的结构见解
Ilenia D&#x;Abbrunzo,Ludovica Battaiotto,Angela Abruzzo et al.
Ilenia D&#x;Abbrunzo et al.
In this study, azithromycin, a broad-spectrum antibiotic compound used for the treatment of several bacterial infections, which is characterized by a very low water solubility, was combined with different small molecules to generate more so...
Proteomic profiling of macrophages: effects of inflammatory activation and anti-inflammatory treatment with IBD therapeutics [0.03%]
炎症激活和IBD药物抗炎治疗的巨噬细胞蛋白质谱分析
Simone Lichtner,Kathrin Schunck,Johanna Frey et al.
Simone Lichtner et al.
Inflammatory bowel diseases (IBD) are chronic disorders characterized by persistent immune dysregulation in the intestinal mucosa, with macrophages playing a central role in disease pathogenesis. In this study, primary human monocyte-derive...
Flowrate-Independent indomethacin dry powder inhaler for potential treatment of pediatric asthma: In vitro aerodynamic and anti-inflammatory evaluation [0.03%]
一种新型的布洛芬干粉吸入剂用于儿科哮喘治疗的可能性：体外气动学和抗炎评价
Nazareth E Ceschan,Andrea V Dugour,Beatriz Behrend et al.
Nazareth E Ceschan et al.
Asthma, a chronic respiratory condition affecting millions globally, is particularly common in children and a leading cause of emergency visits and hospitalizations. Characterized by airway inflammation and increased bronchial sensitivity, ...
Film-forming system of optimized tacrolimus-loaded nanostructured lipid carriers for effective topical treatment of atopic dermatitis [0.03%]
一种优化的他克莫司纳米结构脂质载体薄膜剂型，用于有效治疗特应性皮炎
Jin Sil Kang,Young-Guk Na,Minki Jin et al.
Jin Sil Kang et al.
Tacrolimus (TAC), a calcineurin inhibitor used topically for T-cell-mediated skin diseases, faces challenges due to poor solubility and limited skin penetration. To address these limitations, a film-forming system (FFS) incorporating nanost...
Towards the development of a standard toolbox for compatibility testing of pediatric drug products with common dosing vehicles - Fruit Juice, apple Sauce, Yogurt, and pudding [0.03%]
儿科药品与常见给药辅剂兼容性测试标准工具箱的开发——水果汁、苹果酱、酸奶和布丁
Carolin Eckert,Cordula Stillhart,Leonie Wagner et al.
Carolin Eckert et al.
Co-administration of oral drug products with dosing vehicles is common practice in pediatric drug administration. The present work focused on the development of a set of standard vehicles that reflects the key characteristics of four differ...
Corrigendum to "Hydroquinone cream-based polymer microneedle roller for the combined treatment of large-area chloasma" [Eur. J. Pharm. Biopharm. 185 (2023) 5-12] [0.03%]
关于“基于氢醌霜的聚合物微针滚轮用于大面积黄褐斑联合治疗”一文的勘误[Eur. J. Pharm. Biopharm. 185 (2023) 5-12]
Yu Ting He,Yu Ying Hao,Rui Xing Yu et al.
Yu Ting He et al.
Evaluation and characterization of different extraction methods for obtaining extractable and leachable materials from rubber stopper systems used in pharmaceutical products [0.03%]
用于制药产品的橡胶塞系统的不同提取方法的评估和表征以获得可提取和可浸出物质
Yasin Gökekin,Mehmet Bulut,Büşra Çetin Ersen et al.
Yasin Gökekin et al.
Bromobutyl rubber stoppers are widely used in the primary packaging systems of many different drug products. However, different additives are added to provide the existing properties of these synthetic elastomeric stoppers. The most importa...
Fabrication and in-depth analysis of a novel-hybrid TPGS phytosome system for enhanced anti photoaging efficacy of grape seed extract [0.03%]
一种新型TPGS植物体系统用于增强葡萄籽提取物抗光老化效果的制备及深度探究
Hanan Refai,Mona Elhabak,Doaa H Hassan et al.
Hanan Refai et al.
Photoaging is a widespread skin health concern caused by UV radiation. It significantly contributes to premature wrinkles and exacerbates further skin damage. This study evaluates the enhanced anti-aging efficacy of a nano phytosome incorpo...
Carl Oliver Thiess,Karsten Mäder,Hanns-Christian Mahler et al.
Carl Oliver Thiess et al.
Antibody-Drug Conjugates (ADCs) are nowadays an important therapeutic modality. The (cytotoxic) payload, being the drug, is herewith conjugated to an antibody, which provides targeting. Whilst a lot of attention for technical characterizati...