The interplay between loneliness, cortisol, and NK cell function: The role of cortisol in NK cell dysfunction [0.03%]
孤独感、皮质醇与自然杀伤细胞功能之间的相互作用：皮质醇在NK细胞功能障碍中的作用
Abhinav Saurabh,Yvonne Baumer,Laurel G Mendelsohn et al.
Abhinav Saurabh et al.
Chronic psychosocial stressors contribute to cardiovascular disease (CVD) and related risk factors, particularly in under-resourced communities. Psychosocial stressors activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to susta...
Physical disorders and neuroendocrine vulnerability in the development of posttraumatic stress disorder: A 2-year injury cohort study [0.03%]
身体疾病与应激后 PTSD 神经内分泌易感性的关系——一项两年的损伤队列研究
Hee-Ju Kang,Ju-Wan Kim,Seon-Young Kim et al.
Hee-Ju Kang et al.
This study examined whether the association between early post-trauma cortisol levels and posttraumatic stress disorder (PTSD) onset is moderated by the burden of preexisting physical disorders (PDs), with attention to earlier- versus delay...
Pregnancy cortisol and postpartum depression: The moderating role of optimism [0.03%]
孕期皮质醇与产后抑郁：乐观主义的调节作用
Lauren Giles,Tara Perrot,Tanya Tulipan et al.
Lauren Giles et al.
Postpartum depression (PPD) is one of the most common challenges following childbirth. Left unaddressed, PPD can have enduring consequences for both the birthing individual and child. There is a growing emphasis on promoting resilience to m...
Effects of noradrenergic blockade on emotional working memory and its neural underpinnings: A randomized, double-blind, placebo-controlled trial [0.03%]
noradrenaline拮抗对情绪工作记忆及其神经机制的影响：一项随机双盲安慰剂对照试验
Moritz Hempel,Catarina Rosada,Jule Klockgeter et al.
Moritz Hempel et al.
The neurotransmitter noradrenaline (NA) has been previously associated with brain-wide regulatory functions for various cognitive as well as affective processes. Clonidine, an adrenoceptor agonist, predominantly stimulates α2-receptors, re...
Associations between sedentary behavior and allostatic load: The 1970 British Cohort Study [0.03%]
久坐行为和代偿负荷之间的关系：来自1970年英国队列研究的证据
Aiden J Chauntry,Jake C Diana,Qinghua Li et al.
Aiden J Chauntry et al.
Background: Chronic/repeated exposure to psychological stressors can induce high allostatic load (AL), or multisystem physiological dysregulation, which increases cardiometabolic disease (CMD) risk. While moderate-to-vigo...
Alteration of colonic circadian rhythm by gut microbiota dysbiosis and SCFA reduction links chronic stress-induced depressive-like behavior [0.03%]
肠道菌群失调和SCFA减少所致结肠昼夜节律紊乱与慢性应激诱导的抑郁行为有关
Xuli Wang,Ruisi Liu,Yudong Lin et al.
Xuli Wang et al.
Background: Chronic stress partially leads to depression through the gut-brain axis, yet the underlying multi-level mechanisms remain unclear. This study aims to delineate the pathway from chronic restraint stress (CRS) t...
Telomere trajectories from early adolescence to adulthood following early institutionalization: Protective effects of foster care in the Bucharest Early Intervention Project [0.03%]
保加利亚早年干预项目中机构抚养对青少年成年前后端粒轨迹的影响：寄养照顾的保护效应
Michelle M J Mens,Nigel Walsh Harriman,Ellen Jopling et al.
Michelle M J Mens et al.
Background: Early institutional rearing is associated with adverse biological and health outcomes in later life, including accelerated cellular aging as measured by telomere length. However, the extent to which foster car...
Association of ADHD symptoms with the interactions within and between the HPA axis and melatonin system characterized by hair-based biomarkers [0.03%]
基于毛发生物标志物的HPA轴和褪黑素系统内部及系统间的交互作用与注意缺陷多动障碍症状关联性研究
Sanjun Yi,Xuliang Hou,Guirong Xu et al.
Sanjun Yi et al.
Background: Attention deficit hyperactivity disorder (ADHD) is characterized by abnormal functions of neuroendocrine systems with circadian rhythm, especially for the hypothalamic-pituitary-adrenal (HPA) axis and the mela...
Unipolar depressed inpatients without comorbid personality disorder exhibit elevated IL-6 levels at admission and a decrease after discharge: A longitudinal study [0.03%]
纵向研究：单极障碍住院患者在入院时没有并发人格障碍但IL-6水平升高，出院后降低
Bruno Perosa Carniel,Giulio Bertollo Alexandrino,Luísa Monteiro Burin et al.
Bruno Perosa Carniel et al.
Background: One-third of patients with unipolar depression (UD) do not achieve remission after treatment. There is a growing interest in the role of inflammation in the pathogenesis of UD; however, no study has evaluated ...
Gina-Isabelle Henze,Jens C Pruessner
Gina-Isabelle Henze
Stress engages coordinated psychological, neuroendocrine, autonomic, and neural processes that enable adaptation to environmental demands but may contribute to vulnerability when stress is prolonged, uncontrollable, or socially evaluative. ...