Bismuth meets siderophores: Thermodynamic insights into Bi(III) complexes with Desferrioxamine B and E [0.03%]
铋遇到铁载体：Bi(III)与右旋糖酐铁载体DFOB和E的复合物的热力学见解
Klaudia Szczerba,Wiktoria Jonczyk,Adriana Knoll et al.
Klaudia Szczerba et al.
Bismuth has been used in medicine for centuries and is currently essential for eradicating Helicobacter pylori while also restoring antibiotic sensitivity in multi-drug-resistant strains. Its efficacy is based on a Trojan Horse mechanism wh...
Irene R A M Ogutu,Romila Mascarenhas,Callie G Miller et al.
Irene R A M Ogutu et al.
The metal binding motif of nitrile hydratases (NHases, EC 4.2.1.84) is highly conserved (CXXCSCX) in the alpha subunit. The conserved axial cysteine ligand in both the Co-type and Fe-type NHases was mutated to Ala in Co-type NHases Pseudono...
Synthesis, crystal structure, spectroscopic characterization, theoretical studies and cytotoxicity assays of novel two acylhydrazones and its Cu(II) complexes [0.03%]
两个新型酰腙及其铜配合物的合成、晶体结构、光谱表征、理论研究和细胞毒理学测试
Lucía Santa Maria de la Parra,Mariana Rocha,Victoria de la Sovera et al.
Lucía Santa Maria de la Parra et al.
This work deals with the synthesis and characterization of two novel N-acylhydrazones (H2L1 and H2L2) and its Cu(II) complexes [Cu(HL1)2] and [Cu(HL2)2]. The crystal structures of H2L1 and H2L2 were solved by X-ray diffraction and a detaile...
Multifunctional platinum(IV) complexes reverse cisplatin resistance in triple- negative breast cancer via ferroptosis and apoptosis [0.03%]
多功能的铂(IV)复合物通过铁死亡和凋亡逆转三阴性乳腺癌对顺铂的抗性
Guoxiu Cao,Junjie Zhou,Yuhan Qian et al.
Guoxiu Cao et al.
Platinum(II) drugs are important chemotherapeutical strategies for the triple-negative breast cancer (TNBC) but are frequently hindered by resistance and systematic toxicity. To address these limitations, a series of novel platinum(IV) comp...
Mutation of Pro76 affects the dynamics of Ω-loop D of yeast Iso-1-cytochrome c: Application of gated electron transfer [0.03%]
脯氨酸76点突变影响了酿酒酵母异构体-1细胞色素c的Ω-环D的动力学：电荷门控电子转移的应用
Swati Bandi,Bruce E Bowler
Swati Bandi
Cytochrome c (Cytc) contains two Ω-loops (C, residues 40-57 and D, residues 70-85) that control access of Cytc to alternate conformers needed to convert it from an electron transfer (ET) protein to an enzyme with peroxidase activity. As a ...
Iridium (III) metal complexes induce immunogenic cell death in head and neck cancer cells via endoplasmic reticulum stress [0.03%]
_IRRU金属复合物通过内质网压力诱导头颈部癌细胞免疫原性死亡_
Bi-Wen Wu,Pei-Pei Wang,Yun Zhou et al.
Bi-Wen Wu et al.
Head and neck cancer, the sixth most prevalent malignancy worldwide, presents significant therapeutic challenges for advanced-stage patients due to multidrug resistance and the severe toxicity associated with traditional chemotherapeutic ag...
Chloride complexes [RuII(N-N)(tpy)Cl]+ coordinated to diimine ligand: Kinetic insights into DNA affinity and biological activity [0.03%]
与二亚胺配体配位的氯化物复合物[RuII(N-N)(tpy)Cl]+：关于DNA亲和力及生物活性的动态学见解
Evelyn Christine de Souza Arantes,Naiara Cristina Bessas,Rafaela Luciano de Oliveira Sanches et al.
Evelyn Christine de Souza Arantes et al.
The development of ruthenium(II) polypyridyl complexes as drug candidates requires understanding the influence of geometry and co-ligands on their chemical reactivity and biological activity. In this work, two chloride complexes of the type...
A tribute to Dr. Enrique J. Baran: Teacher, researcher, and outstanding human being [0.03%]
怀念恩里克·J·巴兰博士：一位优秀的教师、研究人员和人道主义者
María H Torre
María H Torre
Dinorah Gambino,Ignacio León
Dinorah Gambino
Structure-activity studies reveal efficient inactivation of urease by Ebsulfur-based compounds [0.03%]
基于乙硫醇的化合物高效灭活脲酶的结构活性研究
Luca Mazzei,Arundhati Paul,Michele Cianci et al.
Luca Mazzei et al.
Antimicrobial resistance is one of the most significant global health threats of the 21st century, demanding urgent strategies for the development of novel therapeutic approaches. Urease, a nickel-dependent enzyme absent in the human proteo...