Mitochondria-targeting iridium(III) complex enhances anticancer activity via PDK inhibition and energy metabolism disruption [0.03%]
靶向线粒体铂配合物通过抑制丙酮酸脱氢酶复合物和扰乱能量代谢增强抗肿瘤活性
Sifan Xu,Na Xu,Hongbao Fang et al.
Sifan Xu et al.
Energy metabolic reprogramming is a key hallmark of cancer cells and holds great promise for the development of metabolic modulators. However, energy metabolic adaptation that facilitates metabolic phenotype from mitochondrial oxidative pho...
Corrigendum to "The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics" J Inorg Biochem 2013 Jan:118:94-9. doi:10.1016/j.jinorgbio.2012.10.003. Epub 2012 Oct 14 [0.03%]
“探究反转移金属钌化合物的分子机制 DIGE 蛋白质组学”文中错误之处修正
Francesca Guidi,Alessandra Modesti,Ida Landini et al.
Francesca Guidi et al.
Published Erratum
Journal of inorganic biochemistry. 2026 Mar 20:113308. DOI:10.1016/j.jinorgbio.2026.113308 2026
Distinct catalytic activity of Staphylococcus Aureus nitric oxide synthase compared to other bacterial NOS-like enzymes [0.03%]
与其它细菌NO合酶相比，金黄色葡萄球菌NO合酶具有独特的催化活性
Zhi-Qiang Wang,Kangyu Xu,Songping Huang et al.
Zhi-Qiang Wang et al.
To better understand the bacterial nitric oxide synthases (bNOSs), we characterized the properties of proteins from Staphylococcus aureus (saNOS) and Bacillus anthracis (baNOS) relative to Bacillus subtilis (bsNOS) and mammalian NOS using b...
Anticancer gold complexes: Controlled activation, precision targeting and beyond [0.03%]
抗癌金配合物：活性调控、精准靶向及其他进展
Yuan Wang,Sinan Zhong,Taotao Zou
Yuan Wang
Gold-based drugs possess a long history of clinical treatment of rheumatoid arthritis with a favorable safety profile. Their unique mechanism of action involving redox regulation holds promise for overcoming the common resistance and toxici...
Metal-tuned antimicrobial peptides and zincophore pathways: from coordination chemistry to targeted therapeutics [0.03%]
金属调节抗菌肽和锌载体途径：从配位化学到靶向药物治疗
Kinga Garstka-Litwin,Magdalena Rowińska-Żyrek
Kinga Garstka-Litwin
Escalating resistance among bacterial and fungal pathogens calls for new therapeutic strategies that go beyond classical small-molecule antibiotics. Antimicrobial peptides (AMPs) are attractive candidates because they can act through multip...
Deconvoluting electrostatic, noncovalent, and magnetic effects of iron-sulfur cofactors inside synthetic cage frameworks [0.03%]
铁硫辅因子在合成笼框架内的静电、非共价和磁效应的去卷积
Rupal Baliyan,Alejandro Javier Castillo,Brett N Schneider et al.
Rupal Baliyan et al.
The electronic states of iron‑sulfur (Fe-S) clusters in metalloenzymes are critically influenced by second and outer-sphere interactions-electrostatics, hydrogen bonding, and hydrophobic contacts-that modulate cofactor redox potentials and...
Structural and functional role of the magnesium ion in the human oxytocin receptor [0.03%]
镁离子在人催产素受体结构和功能中的作用
Francesco Musiani,Samira Al Sadi,Alejandro Giorgetti et al.
Francesco Musiani et al.
The binding of the oxytocin cyclic peptide to its target oxytocin receptor plays a key role for human behaviour. Both binding and receptor activation are affected by the presence of a Mg2+ ion. Unfortunately, the current experimental struct...
Introducing an ultrasensitive glutathione nanozymatic biosensor developed by a novel MOF-nanozyme with intrinsic peroxidase-like activity [0.03%]
一种新型具有内在类过氧化物酶活性的MOF-纳米酶及其在超高灵敏谷胱甘肽纳米酶生物传感器中的应用
Masoud Dehghanipour,Munthar Kadhim Abosaoda,Ashok Kumar Bishoyi et al.
Masoud Dehghanipour et al.
An ultrasensitive glutathione nanozymatic biosensor developed by a novel MOF-nanozyme was introduced. Initially, the MOF-nanozyme was characterized for its enzyme-like activity and chemical/biochemical characteristics. A working pH range of...
nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential and anticancer activity [0.03%]
含尼多卡宾的抗炎药（布洛芬、氟比洛芬和苯巴唑）衍生物的合成、表征及COX抑制活性与抗癌活性研究
Sonam Sonam,Marija Mojić,Markus Laube et al.
Sonam Sonam et al.
The search for novel anticancer drugs with reduced side effects and innovative therapeutic approaches remains a significant challenge. Non-steroidal anti-inflammatory drugs (NSAIDs), known to inhibit cyclooxygenase (COX) - an enzyme overexp...
A Cu(II) binding site involving Cys18 and His22 displays a buffering effect in copper-induced aggregation of cataract-related human γD crystallin [0.03%]
一个与人γD晶状体蛋白质铜诱导聚集的缓冲作用相关的Cu(II)配位位点：含Cys18和His22基序
Eusebio Uc-Santos,Liliana Quintanar
Eusebio Uc-Santos
Cataracts are the main cause of blindness in the world, and they are caused by aggregation of lens crystallin proteins. Metal ions have emerged as a potential factor in the development of cataract disease, as copper and zinc ions induce the...