Glycosylated ancillary ligand bearing Pt(II) anticancer complexes: In vitro and in vivo anticancer evaluation and EMT inhibition in triple-negative breast cancer [0.03%]
糖基化辅助配体负载的Pt(II)抗肿瘤配合物的体内外抗肿瘤活性及其对三阴性乳腺癌上皮间质转化的抑制作用评估
Zerui Wang,Abdul Jamil Khan,Fufu Yan et al.
Zerui Wang et al.
Warburg's effect and elevated glucose transporter (GLUT) activity are defining features of many tumors and offer a route for selective drug delivery. We synthesized a panel of monosaccharide (mannose)-functionalized Pt(II) complexes (C1-C8)...
Bystander effects of a photoactivated ruthenium-based complex in 2D and 3D cell culture models [0.03%]
基于钌的光活化复合物在二维和三维细胞培养模型中的旁观者效应
Amanda Blanque Becceneri,João Vítor Silva Robazzi,Roberto Santana da Silva
Amanda Blanque Becceneri
Photodynamic therapy (PDT) using ruthenium-based photosensitizers (PSs) has attracted increasing interest due to their favorable photophysical properties and their ability to generate reactive oxygen species (ROS) upon irradiation. Although...
Disrupting Leishmania redox homeostasis: Mechanistic insights into a platinum-based antileishmanial complex [0.03%]
铂基抗利什曼病化合物的干扰作用及机制研究：扰乱利什曼原虫氧化还原平衡
Marcus Sávio Araujo Garcia,Vitor Klipel da Silva Bertolini,Fernanda Ramos Gadelha et al.
Marcus Sávio Araujo Garcia et al.
Leishmaniasis remains a major neglected tropical disease, and the development of new chemotherapeutic agents with improved selectivity and novel mechanisms is urgently required. Since the discovery of cisplatin, platinum-based compounds hav...
Insight into the interaction of heme with human calcitonin (hCT) and its inhibitory effect on hCT aggregation [0.03%]
血红素与人降钙素（hCT）相互作用的见解及其对hCT聚集的抑制作用
Huixian Ye,Bin Xiao,Hongxuan Wang et al.
Huixian Ye et al.
Human calcitonin (hCT) is a peptide hormone with therapeutic potential for bone-related disorders, yet its clinical application is hindered by a strong propensity to form amyloid fibrils. Strategies that effectively suppress hCT aggregation...
Photoactivatable diazafluorenone-based ruthenium compounds as a new strategy to combat microbial resistance [0.03%]
光激活的二氮杂荧烯基钌化合物抗微生物耐药性的一种新策略
Francisca Mayara Santos de Alencar,Florencio Sousa Gouveia Jr,Geângela de Fátima Sousa Oliveira et al.
Francisca Mayara Santos de Alencar et al.
Every year, millions of people around the world die due to infections caused by a growing number of resistant bacteria, making urgent the development of new antimicrobial compounds. One promising approach is the use of metal complexes, incl...
Antioxidant and anti-aging properties of a Zn-complex in Saccharomyces cerevisiae: A non-canonical protective mechanism [0.03%]
锌复合物的抗氧化和抗衰老特性：非典型保护机制
Thales de P Ribeiro,Luiza D R Costa,Larissa M M Mattos et al.
Thales de P Ribeiro et al.
Zinc is essential for cellular homeostasis, but its role in oxidative stress resistance and aging remains incompletely understood. We evaluated the antioxidant and anti-aging effects of the zinc(II) coordination compound [Zn2(μ-Cl)2(HPClNO...
Novel Roussin's red salt esters as cardiovascular protectors: "Structure-activity" correlations, properties in solid state and solutions [0.03%]
新型的rousin红色盐酯作为心血管保护剂的研发：结构活性相关性以及固态和溶液性质研究
Оlesya V Pokidova,Veronika O Novikova,Nina S Emel&#x;yanova et al.
Оlesya V Pokidova et al.
A novel binuclear neutral tetranitrosyl iron complexes (NICs) with phenylmethanethiolyl and phenylethanethiolyl ligands were synthesized, and their properties were compared with known phenylthiolyl NIC. It has been shown that in this series...
Circular dichroism: A possible route to shed light on signal transduction processes of heme-based gas-sensor proteins [0.03%]
圆二色性：有可能阐明基于血红素的气体传感器蛋白信号转导过程的一种方法
Wellinson G Guimarães,Josiane Bezerra da Silva Lobão,Marta S P Carepo et al.
Wellinson G Guimarães et al.
Heme-based oxygen-sensor proteins differ in their signal transduction mechanisms. Nevertheless, they all rely directly on the ligation of oxygen to a heme cofactor in one domain to promote regulatory conformational changes in a responsive t...
No heme-chlorite adduct in the catalytic cycle of chlorite dismutase: Insight from QM/MM and dynamics calculations [0.03%]
氯酸盐歧化酶催化循环中不存在血红素-氯酸盐加合物：来自QM/MM和动态计算的见解
Sergiu-Raul Cosma,Dorian Gorgan,Adrian M V Brânzanic et al.
Sergiu-Raul Cosma et al.
Chlorite dismutase (Cld) is one of the rare enzymes capable of forming oxygen‑oxygen bonds. Its catalytic cycle of Cld has been proposed to involve coordination of chlorite to the heme active site (Fe-O-Cl-O), followed by cleavage of one o...
Medicinal applications of bismuth(III): from antimicrobial to anticancer [0.03%]
铋(III)的医药应用：从抗菌到抗肿瘤
Jamie Guan-Tai Lok,Chun-Lung Chan,Quan Hao et al.
Jamie Guan-Tai Lok et al.
Bismuth(III) compounds have long been recognized for their therapeutic potential, owing to their versatile biological activities and relatively low toxicity. The medicinal applications of bismuth(III) complexes are comprehensively summarize...