"Metal-based compounds in antiviral and Antiparasitic research: Mechanistic insights from HIV NCp7 and leishmaniasis case studies" [0.03%]
“基于金属的抗病毒和抗寄生虫研究化合物：HIV NCp7和利什曼病实例分析的机制见解”
Camilla Abbehausen
Camilla Abbehausen
Metallodrugs have long occupied a significant position in medicinal chemistry, yet their application to infectious diseases has historically lagged the extensive development observed in cancer therapy. The COVID-19 pandemic, together with t...
Sifeng Xie,Haitao Wang,Pingyu Zhang
Sifeng Xie
Sonodynamic therapy (SDT) has emerged as a promising cancer treatment modality, offering deep tissue targeting while minimizing damage to surrounding healthy tissues. By combining the deep tissue penetration ability of ultrasound (US) with ...
Cu(I) and Cu(II) binding by hyperactive variants of the human CTR1 N-terminus: Insights from cellular and model peptide studies [0.03%]
人类CTR1氨基端高活性变异体与铜(I)和铜(II)结合：来自细胞及模型肽研究的见解
Kaylee Ruth,Emily Post,Xiaobin Wu et al.
Kaylee Ruth et al.
Copper (Cu) trafficking requires precise control of Cu(II)/Cu(I) redox chemistry to enable cellular acquisition while preventing toxicity. Human Cu transporter 1 protein (hCTR1) mediates cellular Cu uptake, yet key molecular details governi...
A Pb2+-specific DNA G-quadruplex mimic of red fluorescent protein with a monovalent cation ion tolerance [0.03%]
一种对Pb2+特异的红荧光蛋白DNA G-四聚体模拟物及其单正离子耐受性
Jiahuan Zhou,Qiyao Chen,Sihui Huang et al.
Jiahuan Zhou et al.
Nucleic acid mimics of fluorescent proteins (FPs) currently find wide applications in pursuing high-performance sensors and advanced biomedical tools. However, compared to the mimics of green FPs (GFP), the advancement of mimics of red FPs ...
A multifaceted insight into dinuclear salicylatocopper(II) complexes containing 2,2'-bipyridine: Syntheses, structural characterization, spectral properties and biological activity [0.03%]
含2,2'-联吡啶的水杨酸铜(II)二核配合物的多方位研究：合成、结构表征、光谱性质及生物活性
Matúš Lištiak,Jindra Valentová,Rudolf Varga et al.
Matúš Lištiak et al.
The present study reports the syntheses, structural characterization, and biological evaluation of five dinuclear copper(II) complexes containing substituted salicylato ligands and 2,2'-bipyridine as a neutral N,N´-donor ligand: [Cu₂(bpy)...
Towards a dual copper(II) and iron(III) transmetalation strategy for an anticancer application with the deferasirox chelator [0.03%]
一种抗癌应用的双铜(ii)和铁(iii)金属交换策略与去铁斯罗克斯配体配合
Aixa M Orta Rivera,Andrea N Maser-Figueroa,Sergio A Loza-Rosas et al.
Aixa M Orta Rivera et al.
Copper and iron are redox-active essential metals that are disproportionately required by cancer cells to sustain proliferation, survival, and metastasis. Their intertwined biology represents a universal metabolic vulnerability that could b...
Study of DNA/HSA binding by a water-soluble Cu(II) complex with Triazolopyrimidine ligands: Insights from electrochemical impedance spectroscopy analysis [0.03%]
三氮唑并嘧啶配体水溶性Cu(II)配合物与DNA和HSA相互作用的电化学研究
Isabel Del Hierro,José Manuel Méndez-Arriaga,Josefa Ortiz-Bustos et al.
Isabel Del Hierro et al.
A water-soluble copper(II) complex containing triazolopyrimidine ligands was synthesized and extensively characterized, and its interaction with biologically relevant macromolecules, specifically salmon sperm deoxyribonucleic acid (DNA) and...
Evolutionary study of metallo-β-lactamase IMP-1 reveals a specific allosteric network mediated by distal mutations [0.03%]
进化研究发现金属β-内酰胺酶IMP-1通过远端突变介导特定别构网络
Xiao-Ting Dong,Yu-Xuan Dong,Kun Wang et al.
Xiao-Ting Dong et al.
Metallo-β-lactamases (MβLs) are a large contributor to antibiotic resistance. To elucidate how MβLs have evolved with the introduction and use of antibiotics, the mutations and evolution of IMP-1 from Pseudomonas aeruginosa were investig...
Anti-cancer binuclear gold(I) complexes with mixed bis(N-heterocyclic carbene) and bis(diphenylphosphino)carborane ligands inhibit thioredoxin reductase and engage ubiquitin-conjugating enzyme E2 C UBE2C in lung cancer cells [0.03%]
含混合双氮杂环卡宾和双(二苯基磷)碳硼烷配体的抗肿瘤金(I)双核配合物抑制端粒酶倒置重复序列逆转录酶并参与肺癌症细胞中泛素连接酶E2 C UBE2C
Zhi-Feng Zhang,Chun-Nam Lok,Chi-Ming Che
Zhi-Feng Zhang
This article reports on the anti-cancer properties of a series of binuclear gold(I) complexes containing mixed bis(diphenylphosphine)carborane and bis(N-heterocyclic carbene) bridging ligands. Among them, the most active complex, 1b, is sta...
Investigating weak axial ligation in corrinoids by X-ray absorption spectroscopy: Implications for corrinoid iron-sulfur protein [0.03%]
X射线吸收光谱研究维生素B12类似物的弱轴向配位及其对钴氨酶活性的影响
Kewei Zhao,Macon J Abernathy,Claire Griffith et al.
Kewei Zhao et al.
Corrinoid iron‑sulfur protein (CFeSP) is the methyltransferase in the Wood-Ljungdahl pathway, yet the geometric and electronic structure that enables its higher catalytic efficiency relative to small-molecule analogs remains a subject of d...