Thermodynamics, structure, and antibacterial activity of the decavanadate-lysozyme complex [0.03%]
抗细菌活性的十钒酸盐-溶菌酶复合物的热力学、结构及抗菌活性研究
Ola Grabowska,Martyna Kapica,Anna Kloska et al.
Ola Grabowska et al.
This study investigated the influence of highly charged polyanions on protein structure and function using the lysozyme-decavanadate ([V10O28]6-) system as a model. To elucidate the thermodynamic, structural, and functional consequences of ...
Hydrophilicity of heme derivatives influences site-specific tyrosine nitration in MnSOD [0.03%]
血红素衍生物的亲水性影响MnSOD特定位点酪氨酸硝化反应
Huixian Ye,Yiqing Liu,Taiping Zhou et al.
Huixian Ye et al.
Tyrosine nitration is a critical post-translational modification linked to various oxidative stress-related diseases. However, the factors governing site selectivity remain incompletely understood. Manganese superoxide dismutase (MnSOD) is ...
Suppression of glioblastoma progression by novel Phthalocyanine derivatives: In vitro characterization and molecular docking analysis [0.03%]
新型酞菁衍生物抑制胶质母细胞瘤进展：体外特征及分子对接分析
Şuranur Ayvaz,Nevzat Batan,Cihan İnan et al.
Şuranur Ayvaz et al.
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Despite standard treatment prognosis remains poor due high recurrence and rapid therapeutic resistance, highlighting the need for new agents targ...
Synthesis, characterization, Hirshfeld surface analysis of V-substituted Keggin polyoxotungstates and Ca2+-ATPase inhibiting potential [0.03%]
钒取代的 kepgin型多金属氧酸盐的合成、表征及Hirshfeld面分析和Ca2+-ATP酶抑制活性研究
Islem Meskini,Gil Fraqueza,Frédéric Capet et al.
Islem Meskini et al.
Polyoxometalates (POMs) biological and biomedical applications have attracted increasing attention over the past decades. Polyoxometalates are inorganic transition metal oxygen clusters characterized by having multiple structures and tunabl...
Unravelling mechanism of tetrathiomolybdate (TTM) mediated copper sequestration and copper-TTM complex formation in bovine serum albumin [0.03%]
四硫化钼介导的铜螯合及牛血清白蛋白中铜-四硫化钼复合物形成的机制研究
Manmeet Singh,Biplab K Maiti
Manmeet Singh
In pathological conditions, elevated Cu levels in serum albumin are treated with the potent copper chelator, ammonium tetrathiomolybdate (ATTM, [NH4]2[MoS4]), however, the mechanism of Cu sequestration and Cu/TTM complex formation remains u...
Nickel binding shifts Helicobacter pylori HypA toward compact conformations [0.03%]
镍结合使Helicobacter pylori HypA偏向紧缩构象
Stefano Ciurli,Luca Mazzei,Barbara Zambelli et al.
Stefano Ciurli et al.
Helicobacter pylori (Hp) is a Gram-negative human pathogen that relies on the nickel enzymes urease and [Ni,Fe]‑hydrogenase for gastric colonization. Delivery of Ni(II) to the active sites of these enzymes is mediated by the metallochapero...
Chris Orvig: Celebrating His Career and Contributions to Inorganic Biochemistry [0.03%]
克里斯·奥尔维格：纪念他的职业生涯及无机生物化学成就
Tim Storr,Eszter Boros,Peter Caravan
Tim Storr
AnkB, an ankyrin repeat protein form Vibrio cholerae, functions as a heme chaperone for catalase maturation [0.03%]
铜绿假单胞菌ANKB蛋白通过介导细胞内血红素捕获活化 каталаз成熟发挥细胞保护作用
Takeshi Uchida,Wataru Motegi,Ayane Miyashita et al.
Takeshi Uchida et al.
AnkB is an ankyrin repeat-containing protein from Vibrio cholerae. In this study, we examined its role in facilitating heme incorporation into catalase, an enzyme that converts hydrogen peroxide into molecular oxygen and water. To obtain so...
Parallel proton transfer pathways in a metallopeptide artificial hydrogenase [0.03%]
金属肽基人工氢酶中的并行质子转移途径
Ji Won Han,Jose L Alvarez-Hernandez,Afsar Ali et al.
Ji Won Han et al.
Increasing our understanding of proton transfer processes in catalysis is needed to develop efficient catalysts and catalytic systems for proton-requiring reactions. Here, the effects of varying both the outer coordination sphere and exogen...
Ir(III) complexes for photo-activated mitochondrial G-quadruplex damage against cisplatin-resistant cancer cells [0.03%]
用于顺铂耐药癌细胞的光活化线粒体G四链体损伤的铱(III)配合物
Shuqi Huang,Jinrong Yang,Kai Xiong et al.
Shuqi Huang et al.
Lung cancer is the leading cause of cancer-related deaths worldwide, and chemotherapy resistance poses a major challenge in its clinical treatment. Photodynamic therapy offers a promising therapeutic strategy; however, existing photosensiti...