The chemistry of the cobalt corrinoids - Recent advances and emerging themes. Part 2. The biochemistry, microbiology, and ecology [0.03%]
钴血红素的化学：近期进展和新兴主题 第2部分：生物化学、微生物学及生态学
Helder M Marques
Helder M Marques
In this Part 2 of a three-part review of advances in cobalt corrinoid research published between 2020 and 2025, we examine the biochemistry and microbiology of the cobalt corrinoids. Central to this literature is the chemical complementarit...
Substituent effects in picolinic acid-derived silver(I) and zinc(II) complexes: Structure, stability, DNA interactions and therapeutic potential [0.03%]
取代基效应：来源于吡啶甲酸的银(I)和锌(II)配位化合物的结构、稳定性、DNA相互作用及治疗潜力
Michaela Rendošová,Lenka Auxtová,Kristína Harbuľáková et al.
Michaela Rendošová et al.
3-substituted derivatives of picolinic acid, 3-methylpicolinic acid (3-MePicH) and 3-hydroxypicolinic acid (3-OHPicH), were used to investigate their complex-forming, structural, spectral, and thermal properties toward biologically active s...
Cadmium(II) imidazole coordination complexes as selective antifungal agents against resistant Candida: Insights into protein binding, electrochemistry, and CYP51 binding predictions [0.03%]
含咪唑配体的镉配合物作为抗耐药白色念珠菌的选择性抗真菌剂：蛋白质结合，电化学以及与CYP51结合的预测研究
Paulina Truszkowska,Natalia Maciejewska,Dariusz Wyrzykowski et al.
Paulina Truszkowska et al.
Physicochemical and biological properties of four cadmium(II) coordination complexes with 4-methyl-5-imidazolecarboxaldehyde, differing in their inner-sphere halide anions: Cl- (Cd-1), Br- (Cd-2), I- (Cd-3), or the PF₆- counterion of the o...
Synthesis, crystal structure, antibacterial and skin wound healing-promoting effect of nonanuclear bisacylhydrazone Tb cluster [0.03%]
双酰基杂环稀土铽簇的合成、晶体结构及其抗菌和促伤口愈合性能研究
Zhangrui Huang,Wei Wei,Yunjuan Xie et al.
Zhangrui Huang et al.
A novel nonanuclear terbium(III) cluster (9-Tb) supported by salicylaldehyde-condensed phenazinylpyridine bisacylhydrazone was designed, synthesized and fully characterized. Cluster 9-Tb shows excellent structural stability in various solut...
Designing a new pentagonal bipyramidal bridged dinuclear cadmium(II) complex as a bio-active compound: Synthesis, X-ray crystal structures, spectroscopic, DFT, and molecular docking studies [0.03%]
设计一种新的五角双锥桥式双核镉（II）配合物作为生物活性化合物：合成、X射线晶体结构、光谱学、DFT和分子对接研究
Alaa Salim Qand,Ahmed Jasim M Al-Karawi,Abanoub Mosaad Abdallah et al.
Alaa Salim Qand et al.
A new bridged dinuclear cadmium(II) complex: [CdII2(L)2Cl4] (1) is synthesized and characterized through comprehensive spectroscopic and analytical investigations. Each Cd(II) center exhibits a seven-coordinate environment with a distorted ...
Dual competitive mechanisms for CYP3A4-catalyzed gefitinib oxidative defluorination: Steric-conformational coupling and enzymatic/non-enzymatic mechanistic divergence [0.03%]
CYP3A4介导的吉非替尼氧化脱氟的双重竞争机制：立体构象耦合及酶促/非酶促机制分离
Yuxin Shi,Ju Wang,Yang Zeng et al.
Yuxin Shi et al.
Gefitinib is a widely used fluorinated anticancer drug primarily metabolized by cytochrome P450 3A4 (CYP3A4). However, its oxidative defluorination can generate toxic quinone imine metabolites. The mechanistic origin of distinct defluorinat...
How lability impacts the biological activity of polynuclear μ-oxo bridged ruthenium acetates [0.03%]
多核μ-氧桥联钌醋的不稳定性对其生物活性的影响
Pedro Henrique Oliveira Nazar,Felipe Costa Claro Reis,Hugo Elias Barbosa et al.
Pedro Henrique Oliveira Nazar et al.
Complexes of the μ-oxo-bis(μ-acetate)diruthenium class exhibit ligand lability at the positions trans to the μ-oxo bridge. Lability is an important property for numerous drugs, such as cis-[Pt(NH3)2Cl2], given that its biological activit...
Acylhydrazone-based ferrocene-iridium(III) heteronuclear metal complexes: In vivo/in vitro anticancer evaluation towards A549 cell lines [0.03%]
基于酰腙的夹心化合物ferrocene-Ⅲ金属配合物：A549细胞系体内/体外抗肿瘤评价
Xicheng Liu,Can Ye,Yingshen Zhang et al.
Xicheng Liu et al.
Iridium(III) complexes and ferrocenyl derivatives have recently emerged as promising alternatives to platinum-based anticancer agents, owing to their distinctive anticancer mechanisms. This study presented the creation of six acylhydrazone-...
Agents mobilizing Cu(II) from the inert ATCUN complex need both high affinity and a specific chelating structure [0.03%]
高效的铜释放剂需要与ATCUN复合物有高亲和力及特定的螯合结构
Paulina Szczerba,Ewelina Stefaniak,Dawid Płonka et al.
Paulina Szczerba et al.
ATCUN motifs at the N-termini of defined and putative Cu(II) handling proteins provide tight Cu(II) ion binding and prevent the unwanted redox activity of the ion. On the other hand, the Cu(II)-ATCUN complexes exhibit slow or very slow (hou...
Mn(II) MRI contrast agents supported by unsymmetric pyridinophane-picolinate ligands [0.03%]
由不对称吡啶稠合环-烟酸配体支撑的Mn(II) MRI对比剂
Tarek El Sayed,Shreyan Majumdar,Bradley P Sutton et al.
Tarek El Sayed et al.
Gadolinium-based contrast agents are commonly utilized in magnetic resonance imaging (MRI). However, manganese-based agents have attracted increasing interest due to their favorable relaxation properties and enhanced biocompatibility, parti...