Frontiers in Acylthiourea chemistry: Synthesis, metal complexation, and application potential [0.03%]
酰噻唑脲化学的研究进展：合成、金属配位及应用前景
Aamer Saeed,Hina Zaman,Muhammad Azeem et al.
Aamer Saeed et al.
Acyl thioureas are versatile organosulfur scaffolds with broad relevance in coordination chemistry and functional applications, driven by their structural flexibility and the presence of both hard and soft donor sites. This enables the form...
Environment-dependent photochemical behavior of adenosylcobalamin and its influence on the quenching of the 5'-deoxyadenosyl radical [0.03%]
腺苷钴胺素的环境依赖性光化学行为及其对5'-脱氧腺苷自由基淬灭的影响
Alivia Mukherjee,Taylor P McClain,Markus Ruetz et al.
Alivia Mukherjee et al.
Adenosylcobalamin (AdoCbl) shows different photochemical behavior when free in solution compared to when it is bound to the photoregulatory protein CarH. In both cases, the initial photoproduct is cob(II)alamin and the 5'-deoxyadenosyl radi...
The chemistry of the cobalt corrinoids - Recent advances and emerging themes. Part 1: The chemistry and industrial production of cobalt corrinoids [0.03%]
钴科贝林类化合物的化学性质-近期进展与新兴主题 第一部分：钴科贝林类化合物的化学性质及其工业生产
Helder M Marques
Helder M Marques
This is the first part of a three-part review of advances in cobalt corrinoid (B12) research published between 2020 and 2025, focusing on the chemistry and industrial production of cobalt corrinoids. Although vitamin B12 is widely recognise...
Structure activity relationship of L-Ir(III)Cl-cp complexes interfering CDK4-cyclin D1 and AKT-mTOR pathways to suppress colorectal cancer tumorigenesis and induce cell death via PARP and caspase-3 pathways [0.03%]
L-Ir(III)Cl-cp类化合物通过CDK4-cyclin D1和AKT-mTOR信号通路干预结直肠肿瘤发生及诱导细胞凋亡的结构活性关系研究
Yuting Zhang,Jiale Qin,Lijing Liu et al.
Yuting Zhang et al.
Naphthyl-functionalized half-sandwich Ir(III) complexes were designed as non‑platinum metal candidates for colorectal cancer cell growth inhibition, the naphthyl group was purposefully introduced in the ligands in order to facilitate DNA i...
A novel Dinuclear rhenium(I) Tricarbonyl complex as a potential anticancer agent: Synthesis, structural characterisation, in vitro evaluation, density functional theory, and molecular docking binding modes [0.03%]
一种新的二聚体金属配合物作为潜在的抗癌剂：合成，结构特征，体外评估，密度泛函理论以及分子对接结合模式研究
Lesetja V Ramoba,Amani Direm,Farida Hakkar et al.
Lesetja V Ramoba et al.
Rhenium tricarbonyl complexes in their monometallic forms have been extensively studied, mainly for their potent inhibitory activity against cancer cells. However, far fewer dinuclear complexes have been investigated for similar application...
Bimetallic Anilinopyridinate ruthenium(II,III) complexes: Synthesis, characterisation, and in vitro selective cytotoxicity towards MCF-7 breast cancer cells [0.03%]
双金属苯并咪唑配体钌(II，III)配合物的合成与表征及其对MCF-7乳腺癌细胞的选择性体内细胞毒作用
Thato T Medupe,Nirvashi D Autar,Claire Bellis et al.
Thato T Medupe et al.
Cancer is the second leading cause of death worldwide. Treatment options such as conventional chemotherapeutic agents often have significant shortcomings. To address such treatment modalities, ruthenium(III) prodrugs offer promise as antica...
Ca2+ effects on manganese oxidation by the bacterial multicopper oxidase complex Mnx [0.03%]
钙对细菌多铜氧化酶复合物Mnx介导的锰氧化的作用
Alexandra V Soldatova,Christine A Romano,Jesse W Wilson et al.
Alexandra V Soldatova et al.
Dormant spores of manganese-oxidizing Bacillus sp. oxidize dissolved manganese, producing insoluble manganese oxide mineral. Many of them do so with the help of Mnx-a protein complex of a catalytically active multicopper oxidase enzyme MnxG...
The chemistry of the cobalt corrinoids - Recent advances and emerging themes. Part 3. Cobalamins and health [0.03%]
钴科血红素化学的新进展和新课题（第三部分）：钴氨素与健康
Helder M Marques
Helder M Marques
Vitamin B12 (cobalamin) is an essential micronutrient whose biological importance extends beyond its traditional classification as a haematinic vitamin. This third and final part of a review covering work published between 2020 and 2025 syn...
PIKfyve-specific Pt(II)-based targeted drug conjugate in treatment of ovarian cancer through multi-mode actions [0.03%]
PIKfyve特异性的Pt(II)基于靶向药物结合物通过多模式作用治疗卵巢癌
Heng Zhang,Gang Xu,Shaohua Gou
Heng Zhang
Ovarian cancer treatment has long been challenged by clinical obstacles including platinum resistance recurrence and incomplete eradication of micrometastatic lesions. This study presents a platinum(II)-based compound AP-604 through the "Ta...
From PET to targeted radionuclide therapy in the Brain: The emerging role of radiometal-based platforms [0.03%]
从正电子发射断层扫描到脑部精准核素治疗：放射金属基平台的新兴作用
Jacqueline Cawthray
Jacqueline Cawthray
Radiometal-based radiopharmaceuticals have become central to the advancement of molecular imaging and targeted radionuclide therapy, offering powerful tools for the diagnosis and treatment of diseases affecting the brain. The unique chemica...