Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)-mediated ER stress crosstalk with autophagy is involved in tris(2-chloroethyl) phosphate stress-induced cardiac fibrosis [0.03%]
三(2-氯乙基)磷酸盐诱导的心脏纤维化过程中，内质网应激与自噬之间的串扰与Sarco/内质网Ca2+ATP酶（SERCA）介导的内质网钙离子稳态失衡有关
Xuan Xiong,Xiaoqin Zhang,Yuan Zhang et al.
Xuan Xiong et al.
Excessive organophosphate flame retardant (OPFR) use in consumer products has been reported to increase human disease susceptibility. However, the adverse effects of tris(2-chloroethyl) phosphate (TCEP) (a chlorinated alkyl OPFR) on the hea...
John H Dawson
John H Dawson
A split β-lactamase sensor for the detection of DNA modification by cisplatin and ruthenium-based chemotherapeutic drugs [0.03%]
用于顺铂和基于钌的化疗药物DNA改性的裂解型β-内酰胺酶传感器
Samuel R Hinton,Elizabeth L S Corpuz,Karen L McFarlane Holman et al.
Samuel R Hinton et al.
Here we present a split-enzyme sensor approach for the sequence-specific detection of metal-based drug adducts of DNA. Split β-lactamase reporters were constructed using domain A of the High Mobility Group Box 1 protein (HMGB1a) in conjunc...
Dissociation of the proximal His-Fe bond upon NO binding to ferrous zebrafish nitrobindin [0.03%]
一氧化氮结合后斑马鱼硝基蛋白His-Fe近端键的解离
Giovanna De Simone,Paola Fattibene,Federico Sebastiani et al.
Giovanna De Simone et al.
Nitrobindins (Nbs) are all-β-barrel heme-proteins present in prokaryotes and eukaryotes. Although the physiological role(s) of Nbs are still unclear, it has been postulated that they are involved in the NO/O2 metabolism, which is particula...
Mechanisms underlying the inhibitory effects of Cd2+ on prodigiosin synthesis in Serratia marcescens KMR-3 [0.03%]
Cd2+抑制Serratia marcescens KMR-3次黄嘌呤合成的机制研究
Guodong Zhu,Wenzhang Tan,Liguo Xie et al.
Guodong Zhu et al.
Prodigiosin (2-methyl-3-pentyl-6-methoxyprodiginine), a red-colored microbial pigment, is produced in large quantities by Serratia marcescens KMR-3. This bacterium can grow in a medium with a Cd2+ concentration of 500 mg/L, but it does not ...
Rifat Farhana,Ruipeng Lei,Khoa Pham et al.
Rifat Farhana et al.
Several novel members of the vertebrate globin family were recently discovered with unique structural features that are not found in traditional penta-coordinate globins. Here we combine structural tools to better understand and recognize m...
Antitumor activity of copper(II) complexes with Schiff bases derived from N'-tosylbenzene-1,2-diamine [0.03%]
N'-托烷磺酰苯-1,2-二胺缩氨基硫脲铜（II）配合物的抗肿瘤活性研究
María Diz,María L Durán-Carril,Jesús Castro et al.
María Diz et al.
The electrochemical oxidation of anodic metal copper in a solution of the ligands N-[(5-tert-butyl-2-hydroxyphenyl)methylidine]-N'-tosylbenzene-1,2-diamine [H2L1] and N-[(3,5-di-tert-butyl-2-hydroxyphenyl)methylidine]-N'-tosylbenzene-1,2-di...
ZnO NPs immobilized by Alizarin as in vitro predictive and imaging biomarkers for protein amyloidosis [0.03%]
作为体外预测和成像生物标志物的阿佐莱因固定的ZnO纳米颗粒
Kleoniki Giannousi,Maria-Eleni Karageorgou,Ilias M Oikonomou et al.
Kleoniki Giannousi et al.
Protein amyloidosis represents the main pathological hallmark of many incurable neurodegenerative disorders and protein misfolding diseases. Nanomaterials-based approaches give rise to diagnosis and/or prediction of these proteinopathies, w...
The role of tridentate ligands on the redox stability of anticancer gold(III) complexes [0.03%]
三齿配体在抗肿瘤金(III)配合物中的作用及对配合物氧化还原稳定性的研究
Giset Y Sánchez Delgado,Frederico Henrique do C Ferreira,Diego F S Paschoal et al.
Giset Y Sánchez Delgado et al.
Gold(III) complexes are promising compounds for cancer chemotherapy, whose action depends on their redox stability. In this context, the choice of ligands is crucial to adjust their reactivity and biological response. The present study addr...