Integrating a fluorescent coumarin core into Schiff base half-sandwich Ir(III) or Ru(II) complexes for mitochondria-mediated anticancer activity [0.03%]
含荧光香豆素核的席夫碱半夹层铱(III)或钌(II)配合物介导线粒体抗肿瘤活性的研究
Peijie Liang,Lei Qi,Yongbin Chen et al.
Peijie Liang et al.
To merge the intrinsic fluorescence and bioactivity of coumarin with the anticancer efficacy of Schiff base metal complexes, a series of half-sandwich Ir(III) and Ru(II) complexes bearing coumarin-salicylaldimine (N^O) ligands were designed...
Pyridine-containing iridium complexes as gram-negative bacteria specific therapeutic agents with low resistance development [0.03%]
含吡啶的铱配合物作为特异性治疗革兰氏阴性菌的药物且难产生抗药性
Yan Zhang,Liang Shao,Ziyi Wang et al.
Yan Zhang et al.
The propensity of antibiotics to provoke drug resistance in clinical applications, along with their low selectivity, has collectively contributed to the problem of antibiotic misuse, posing a major challenge in contemporary antibacterial th...
Selective tumor accumulation as a route to precision medicine for platinum anticancer drugs [0.03%]
铂类抗癌药物的选择性肿瘤蓄积作为精准医学的途径
Erica J Peterson,Nicholas P Farrell
Erica J Peterson
This brief review summarizes our work showing that glycosaminoglycans (GAGs) are mediators of platinum complex cellular accumulation. Especially, there is an inverse relationship whereby charged polynuclear platinum complexes exemplified by...
Formation and spontaneous oxidation of neutral [4Fe-4S] clusters in prebiotic oceans [0.03%]
前生命海洋中中性[4Fe-4S]簇的形成和自发氧化
Theodore M Present,Joan Selverstone Valentine,Jena E Johnson et al.
Theodore M Present et al.
Iron‑sulfur clusters are enzyme cofactors essential to life and are proposed to form the basis of earliest metabolisms. Fe-S rhomb and cubane clusters require both Fe(II) and Fe(III) for stability, but the Archean ocean was dominated by re...
Human radical S-adenosylmethionine domain-containing 1 (RSAD1) is a Heme-binding protein [0.03%]
人类S-腺苷甲硫氨酸域含1蛋白（RSAD1）是一种血红素结合蛋白
Oleg A Zadvornyy,Mikhail Drobizhev,Monika Tokmina-Lukaszewska et al.
Oleg A Zadvornyy et al.
Human radical S-adenosyl-l-methionine domain-containing 1 (hRSAD1) is a recently discovered mitochondrial protein that plays an important yet not fully understood role in cellular function. hRSAD1 belongs to the large and diverse radical S-...
Synthesis and structural characterization of zinc(II) carboxylate complexes with antibacterial and in vivo antibiofilm activities [0.03%]
具有抗菌和体内抑菌活性的锌(II)羧酸盐配合物的合成与结构表征
Hazrat Bilal,Cai-Xiang Zhang,Huichao Lin et al.
Hazrat Bilal et al.
Six zinc(II) carboxylate complexes were synthesized under reflux reactions and thoroughly characterized by single crystal X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray photoele...
Cyclodextrin-siderophore conjugates as a Trojan horse strategy for bacterial targeting [0.03%]
利用环糊精-铁载体偶联物实现细菌靶向的特洛伊木马策略
Chiara Ragusa,Roberta Panebianco,Vincenzo Paratore et al.
Chiara Ragusa et al.
The rise of antibiotic resistance necessitates the development of innovative strategies to enhance the effectiveness of existing treatments. One promising approach leverages bacterial iron acquisition systems through siderophore-based drug ...
Emilie Mathieu,Christelle Hureau
Emilie Mathieu
Probing anion recognition in a cobalt(II) de novo designed metalloprotein [0.03%]
探究钴(II)从头设计金属蛋白中的阴离子识别能力
Salvatore La Gatta,Jacob K Firby,James E Penner-Hahn et al.
Salvatore La Gatta et al.
Anions such as halides and pseudohalides influence metal-site structure and function. De novo designed metallocoiled coils offer a defined platform for studying how metal centers recognize small anions within an α-helical scaffold. Spectro...
Matthew D Liptak,Amit R Reddi
Matthew D Liptak