Corrigendum to "Comprehensive non-small cell lung cancer targets: From computational prediction to clinical breakthroughs in overcoming drug resistance" [Biochem. Pharmacol. 242(Part 2) (2025) 117333] [0.03%]
关于“全面的小细胞肺癌靶点：从计算预测到临床突破，克服药物耐药性”一文的勘误(生物化学与药理学杂志第242卷(第二部分)(2025年)117333号论文)
Wanjie Zheng,Zhiheng He,Jiarui Liu et al.
Wanjie Zheng et al.
Published Erratum
Biochemical pharmacology. 2026 Feb 13:247:117778. DOI:10.1016/j.bcp.2026.117778 2026
GLIS3, a novel regulator of eicosanoid gene expression and metabolism in normal kidney and polycystic kidney disease [0.03%]
GLIS3是正常肾脏和多囊肾疾病的白三烯基因表达及代谢的新调节因子
Chitrangda Srivastava,Hong Soon Kang,Matthew L Edin et al.
Chitrangda Srivastava et al.
Loss of function of the Krüppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) causes polycystic kidney disease (PKD) indicating that it plays a critical role in regulating normal kidney functions. The first postnatal month is...
5-Fluorouracil-induced intestinal mucositis: Pathogenesis and potential therapeutic interventions [0.03%]
5-氟尿嘧啶诱导的肠黏膜炎：发病机制及潜在治疗手段
Sen-Lin Li,Dao-Chun Xiang,Ping Gao et al.
Sen-Lin Li et al.
Intestinal mucositis is one of the most common toxicities of 5-fluorouracil (5-FU)-based chemotherapy, occurring in up to 80% of treated patients. Clinically, it presents as abdominal pain, watery or bloody diarrhea, malabsorption and body-...
Targeting PDK4 attenuates neointimal hyperplasia and regulates VSMC phenotypic switching, apoptosis, and autophagy [0.03%]
靶向PDK4减轻新生内膜增生并调控血管平滑肌细胞表型转换、凋亡及自噬
Ankan Sarkar,Sakeel Ahmed,Monika Singh et al.
Ankan Sarkar et al.
Neointimal hyperplasia, a predominant cause of restenosis and atherosclerosis, is regulated by the phenotypic modulation, migration and proliferation, of vascular smooth muscle cells (VSMCs). Pyruvate dehydrogenase kinase 4 (PDK4) has been ...
Targeting the FAPα/Integrin αvβ1 complex attenuates hepatic stellate cell activation and liver fibrosis [0.03%]
靶向FAPα/整合素αvβ1复合体可抑制肝星状细胞活化和肝纤维化
Chun Guan,Nuo Cheng,Yu Tong et al.
Chun Guan et al.
Hepatic stellate cell (HSC) activation is central to liver fibrosis. Fibroblast activation protein α (FAPα) is highly expressed in activated HSCs, yet its regulatory role remains unclear. This study investigates the function and mechanism...
Dual-Targeting Bcl-2-Mediated apoptosis and synergistic Pathways: Combinatorial strategies to overcome therapeutic resistance in cancer [0.03%]
双重靶向Bcl-2介导的凋亡和协同途径：克服癌症治疗抵抗的组合策略
Jiongjia Cheng,Haiying Wang,Yuchi Zhang et al.
Jiongjia Cheng et al.
Dysregulation of apoptosis pathways is a defining characteristic of cancer, that has established pro-apoptotic activation as a fundamental therapeutic strategy in oncology. The B-cell lymphoma-2 (Bcl-2) family proteins serves as master regu...
PACS2 deficiency ameliorates hepatic steatosis via inhibition of the JNK signaling pathway in diabetic mice [0.03%]
PACS2缺乏通过抑制糖尿病小鼠的JNK信号通路改善肝脂肪变性
Hang Zou,Shiying Qin,Hongwei Lu et al.
Hang Zou et al.
Hepatic steatosis is a frequent complication of diabetes. To investigate the role of PACS2 in glucose and lipid metabolism in diabetic mice and to determine the underlying mechanisms. PACS2-/- mice were used to establish diabetic models by ...
Exploring the mechanism of nonylphenol-induced myocardial fibrosis based on TGF-β1/Smads signaling pathway [0.03%]
基于TGF-β1/Smads信号通路的壬基酚诱导心肌纤维化的机制研究
Weichu Liu,Fengwen Yang,Jie Yu
Weichu Liu
Myocardial fibrosis (MF) is a central feature in the terminal stages of many cardiovascular diseases. Findings from a previous study that we conducted show that when exposed to perinatal nonylphenol (NP), adult male rats developed MF. Howev...
β - sitosterol promotes the SUMOylation of DRP1 in alveolar macrophages and alleviates sepsis-associated acute lung injury [0.03%]
β-谷固醇通过促进肺泡巨噬细胞中DRP1的SUMO化来缓解脓毒症相关急性肺损伤
Bailun Wang,Ziyi Zhou,Chang Sun et al.
Bailun Wang et al.
Acute lung injury (ALI) represents the most frequent complication of sepsis; however, effective drug-based interventions are still unavailable. β-sitosterol (BS) has demonstrated anti-inflammatory effects and protective properties on alveo...
Kukoamine A attenuates allergic rhinitis via H1R antagonism: Dual suppression of inflammatory signaling and epithelial barrier disruption [0.03%]
库可胺A通过拮抗H1R缓解过敏性鼻炎：同时抑制炎症信号转导和上皮屏障损伤
Panpan Lei,Xiaoyu Ma,Yuxiu Zhang et al.
Panpan Lei et al.
Allergic rhinitis (AR) has emerged as a significant global health burden with steadily rising prevalence. As the histamine 1 receptor (H1R) plays a central role in allergic responses, it remains a key therapeutic target for AR. In this stud...