Chimeric antigen receptor T cell therapy for glioblastoma: overcoming current barriers and strategies to enhance efficacy for therapeutic implications [0.03%]
嵌合抗原受体T细胞治疗胶质母细胞瘤：克服当前障碍及增强疗效的策略
Muhammad Abid Hayat,Si Yu,Guo Tao et al.
Muhammad Abid Hayat et al.
Glioblastoma (GBM) is a highly malignant primary brain tumor, characterized by limited therapeutic options and poor survival outcomes. Nevertheless, its treatment is significantly hampered by the immunosuppressive tumor microenvironment, tu...
The cGAS-STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology [0.03%]
cGAS-STING信号通路：肌肉病理生理学中的一个中心调节因子和潜在治疗靶点
Haiyan Jiang,Yanan Ji,Tongxin Shang et al.
Haiyan Jiang et al.
The cGAS-STING signaling pathway is a central component of the innate immune system. Skeletal muscle, the body's largest metabolic and endocrine organ, is essential for overall health, and maintaining its homeostasis is critically important...
Unlocking the potential of antimicrobial lipopeptides: a pathway to combat multidrug-resistant pathogens [0.03%]
抗菌脂肽的潜力展望：对抗多重耐药病原体的新路径
Kaikai Lv,Yuxin Fang,Chenpeng He et al.
Kaikai Lv et al.
Antimicrobial lipopeptides (AMLPs) have emerged as a promising class of therapeutic agents against multidrug-resistant pathogens due to their unique amphiphilic structure and multimodal mechanisms of action. This review systematically summa...
The therapeutic potential of cytisine and its derivatives in disorders of the central nervous system [0.03%]
cytisine及其衍生物在中枢神经系统疾病治疗中的潜力
Ming Cheng,Danchen Zhu,Shuyu Chen et al.
Ming Cheng et al.
Cytisine is a quinolizidine alkaloid that is widely used in smoking cessation, exerting its neurological and other biological actions primarily through binding to the nicotinic acetylcholine receptor (nAChR). Cytisine binds to the nAChR (he...
Corrigendum to "Givinostat rescues folding of cystathionine beta-synthase and ameliorates murine homocystinuria" [Biochem. Pharmacol. 239 (2025) 117079] [0.03%]
关于“Givinostat 拯救胱硫醚β合成酶的折叠并改善小鼠同型半胱氨酸血症”的勘误[Biochem. Pharmacol. 239 (2025) 117079]
Maria Petrosino,Karim Zuhra,Ela Mijatovic et al.
Maria Petrosino et al.
Published Erratum
Biochemical pharmacology. 2026 Feb 27:248:117842. DOI:10.1016/j.bcp.2026.117842 2026
Sodium aescinate induces renal cell ferroptosis through the ATF4/CTH/SQOR axis [0.03%]
槐果寥子素通过ATF4/CTH/SQOR轴诱导肾细胞铁死亡
Wupei Pan,Xiaoyi Zou,Wenxin Tang et al.
Wupei Pan et al.
Sodium aescinate (SA), derived from seeds of the Chinese herb Suoluozi (Aesculus wilsonii Rehd.), has been linked to severe kidney injury during clinical use. We previously found that SA induces nephrocyte ferroptosis, and upregulation of g...
Celastrol induces liver cancer cell death via TFEB-Mediated lysosome activation and ROS-Dependent ferroptosis [0.03%]
Celastrol通过TFEB介导的溶酶体激活和ROS依赖性铁死亡诱导肝癌细胞凋亡
Jing Ma,Yong-Zhuo Li,Mei-Xiu Li et al.
Jing Ma et al.
The development of effective and low-toxicity therapies for liver cancer and other malignancies remain an unmet clinical challenge, primarily due to dysregulated cancer cell proliferation and therapeutic resistance. In this study, we demons...
Half-life extension and immunogenicity in therapeutic proteins: mechanisms, trade-offs, and a decision framework [0.03%]
治疗性蛋白质的半衰期延长及免疫原性：机制、权衡及决策框架
Yingping Chen,Yinchu Song,Yiwen Xie et al.
Yingping Chen et al.
Therapeutic proteins are central to modern pharmacotherapy, yet their clinical utility is often constrained by short plasma half-life and immunogenicity. Six major half-life extension platforms-PEGylation, hydrophilic polypeptide (XTEN/PAS)...
Cabozantinib inhibits necroptosis by targeting MLKL oligomerization and alleviates psoriasis in vivo [0.03%]
卡博替尼通过靶向MLKL寡聚化抑制坏死性凋亡并缓解银屑病
Rui He,Yanzhen Li,Yu Sun et al.
Rui He et al.
Necroptosis is a regulated form of cell death characterized by inflammation, driven by activation and oligomerization of mixed lineage kinase domain-like protein (MLKL), which disrupts the plasma membrane and triggers release of damage-asso...
RNA polymerase I inhibitor CX-5461 suppresses cervical cancer cell growth by inducing DNA damage and mitotic catastrophe and enhances cisplatin sensitivity [0.03%]
RNA聚合酶I抑制剂CX-5461通过诱导DNA损伤和有丝分裂灾难来抑制宫颈癌细胞的生长并增强顺铂敏感性
Xiaoli Liu,Ting Xu,Jiaqi Wu et al.
Xiaoli Liu et al.
Cervical cancer is one of the most common malignant tumors among women worldwide. In some regions, its incidence and mortality rates remain high, and patients with HPV-unassociated tumors often have a poor prognosis. Those with advanced or ...