Kaempferol reprograms pro-inflammatory macrophage polarization by targeting the PTGS2-PGE2 axis: A multi-omics deconvolution of a traditional anti-inflammatory herb pair [0.03%]
山柰酚通过靶向PTGS2-PGE2轴重编程促炎型巨噬细胞极化：一种传统抗炎中药对的多组学解析方法研究
Han Chen,Shuying Chen,Haixia Huang et al.
Han Chen et al.
Metabolic dysfunction-associated steatohepatitis (MASH), a progressive liver disease driven by pro-inflammatory (M1) macrophage polarization, lacks effective pharmacotherapies. While the Chaihu-Baishao (CB) herb pair is a traditional remedy...
Nebivolol-induced bi-directional modulation of intracellular kinases contributes to the inhibition of triple-negative breast cancer [0.03%]
奈倍地洛双向调节胞内激酶抑制三阴性乳腺癌的作用及机制研究
Huiwen Guan,Yunjun Ge,Qianqian Cao et al.
Huiwen Guan et al.
Stress-induced β-adrenergic signaling is widely recognized as a detrimental factor in breast cancer progression, and β-blockers have been shown to exert beneficial effects on breast cancer patients in various clinical settings. However, t...
Integration of multi-omics and machine learning to reveal the anti-osteoporosis effects of Hederagenin by inhibiting lipid peroxidation via the GPX4/p-STAT1/PTGS2 axis [0.03%]
整合多组学和机器学习揭示Hederagenin通过GPX4/p-STAT1/PTGS2轴抑制脂质过氧化的抗骨质疏松作用
Junliang Lu,Baihui Yang,Danming Gan et al.
Junliang Lu et al.
Osteoporosis (OP) is a multifactorial disease, leading to abnormal bone remodeling, requiring targeted therapeutic interventions. This study investigated the pharmacological effects of Hederagenin (Hed), a triterpenoid saponin, in ovariecto...
YTHDF2 alleviates diabetic cardiomyopathy by targeting m6A-mediated degradation of lncRNA RMRP and inhibiting NLRP3-dependent pyroptosis [0.03%]
YTHDF2通过靶向m6A介导的RMRP降解和抑制NLRP3依赖性焦亡来缓解糖尿病心肌病
Yanjie Xu,Wenqi Xiong,Congcong Xu et al.
Yanjie Xu et al.
Diabetic cardiomyopathy (DCM) poses a significant threat to diabetic patients, with NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation playing a critical role. In this research, we identified a previously unr...
Inhibition of mitochondrial integrated stress response ameliorates ibuprofen-induced endothelial dysfunction in neonatal hyperoxia-induced lung injury [0.03%]
线粒体整合应激反应抑制改善了早产儿高氧性肺损伤的布洛芬致内皮功能障碍
Xuan Wang,Bingchun Lin,Lingling Yang et al.
Xuan Wang et al.
Ibuprofen is a nonsteroidal anti-inflammatory drug with promising activity against patent ductus arteriosus (PDA) in premature infants, but its adverse effect on angiogenesis has hampered the clinical benefit and contributed to development ...
Therapeutic interference of SREBP-mediated lipid metabolism by E-Xanthohumol attenuates prostate cancer progression [0.03%]
姜黄素通过XANTHOHUMOL介导的SREBP脂质代谢治疗干预抑制前列腺癌进展
Jonathan Viehoever,Naveen Surya Velmani,Vignesh Basavaraj et al.
Jonathan Viehoever et al.
Aberrant lipid metabolism, driven by two key transcriptional regulators (SREBP-1 and SREBP-2) and their downstream enzymes, contributes to prostate cancer (PCa) development and progression to lethal castration-resistant PCa (CRPC). Targetin...
Novel 1,2,3-triazole-based compound triggers apoptosis through DNA damage response involving ATM/ATR signaling in liver cancer cells [0.03%]
新的1,2,3-三唑化合物通过涉及ATM / ATR信号的DNA损伤反应触发肝癌细胞凋亡
Yao Lu,Sisi Cheng,Yining Zhang et al.
Yao Lu et al.
1,2,3-Triazole-substituted cabotegravir analogues, i.e., KJ-9, have been developed as lead structures to explore their potential as antitumor agents. The new analogue exhibited significant anti-proliferative activity against various human c...
Activation of the human β3 GABAA receptor by combinations of receptor protonation with chemical agonists and gain-of-function mutations [0.03%]
人β3型GABA受体的激活是由受体质子化与化学激动剂和功能获得性突变相结合引起的
Allison L Germann,Spencer R Pierce,Joe Henry Steinbach et al.
Allison L Germann et al.
Native GABAA receptors are continuously exposed to numerous active compounds, including protons, whose net activating and modulatory effects determine receptor function and underlie the inhibitory tone in the brain. Here, we have investigat...
USP30 alleviates intestinal ischemia-reperfusion injury by deubiquitinating MFN2 mediating the mitochondrial endoplasmic reticulum pathway [0.03%]
USP30通过去泛素化MFN2介导的线粒体-内质网接点缓解肠道缺血再灌注损伤
Ziyi Weng,Tulanisa Kadier,Ruili Ding et al.
Ziyi Weng et al.
Intestinal ischemia-reperfusion (IIR) injury can cause intestinal barrier damage, systemic inflammatory response, and high mortality. The key mechanism is the disorder of the mitochondrial-endoplasmic reticulum network. Ubiquitin-specific p...
ZFP36 inhibits trophoblast ferroptosis and attenuates preeclampsia development by promoting NCOA4 mRNA degradation and suppressing ferritinophagy [0.03%]
ZFP36通过促进NCOA4 mRNA降解和抑制铁死亡自噬来抑制滋养细胞铁死亡并缓解子痫前期发展
Man Gao,Xue Yang,Xiuxia Wang et al.
Man Gao et al.
Preeclampsia (PE), a pregnancy-specific disorder characterized by placental dysfunction and severe maternal-fetal complications, involves ferroptosis-an iron-dependent cell death driven by oxidative stress and lipid peroxidation. This study...