GPR68, a proton-sensing GPCR, as a therapeutic target in depression: structural, signalling, and mechanistic perspectives [0.03%]
作为抑郁症治疗靶点的GPR68（一种质子感应G蛋白偶联受体）的结构、信号传导和机制研究视角
Qing-Xi Lu,Xiang-Ming Cai,Wei Guan
Qing-Xi Lu
Brain acid signalling refers to the process by which brain tissue utilizes protons (H+) as signalling molecules to sense changes in the extracellular microenvironmental pH via specific receptors such as proton-sensing GPCRs. This signalling...
Baimaside, a flavonoid glycoside from Apocynum venetum, ameliorates sepsis by allosterically inhibiting NF-κB p50-mediated IL-6 transcription [0.03%]
苦豆素通过别构抑制NF-κB p50介导的IL-6转录来改善脓毒症
Yan Zhang,Wenjuan Li,Yingxue Liang et al.
Yan Zhang et al.
Sepsis, a life-threatening inflammatory syndrome, is characterized by excessive cytokine production, particularly interleukin-6 (IL-6), which drives systemic inflammation and organ dysfunction. This study investigates the anti-inflammatory ...
Exploring the binding kinetics of intracellular allosteric antagonists for CC chemokine receptor 2 - a key to improve insurmountable antagonism [0.03%]
探究细胞内别构拮抗剂与CC趋化因子受体2结合的动力学特点：提高非竞争性抑制作用的关键
Yao Yao,Lisa S den Hollander,Bente Bleijs et al.
Yao Yao et al.
CC chemokine receptor 2 (CCR2), a class A G protein-coupled receptor (GPCR), represents a promising therapeutic target for inflammatory and autoimmune diseases. Although several CCR2 antagonists have advanced to clinical trials, none have r...
Integrating single-cell atlases and machine learning to construct 'in silico patients' for predicting individualized drug responses [0.03%]
整合单细胞图谱和机器学习构建“计算患者”以预测个体化药物反应
Zhuo Zuo,Yulong Sun
Zhuo Zuo
Intratumoral cellular heterogeneity is a core challenge that drives drug resistance and hinders the advancement of precision oncology. Single-cell RNA sequencing (scRNA-seq) has revealed the complexity of the tumor ecosystem at unprecedente...
Corrigendum to "Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload" [Biochem. Pharmacol. 220 (2024) 115962] [0.03%]
“密蒙花苷通过调节TRPV1依赖性钙超载抑制顺铂引起的耳毒性”的勘误表 [Biochem. Pharmacol. 220 (2024) 115962]
Yuhan Lin,Rui Liang,Kairong Xie et al.
Yuhan Lin et al.
Published Erratum
Biochemical pharmacology. 2026 Mar 6:248:117855. DOI:10.1016/j.bcp.2026.117855 2026
Differential modulation of the sGC-cGMP pathway by sGC stimulators and activators in human lung cells [0.03%]
血红素调节的鸟苷酸环化酶刺激剂和激活剂对人肺细胞中sGC-cGMP通路的不同调节作用
Paula Montero,María Amparo Bayarri,Inés Roger et al.
Paula Montero et al.
Chronic lung diseases are characterized by oxidative stress, inflammation, and fibroproliferation, conditions that impair nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic GMP (cGMP) signaling. Here, we investigated the differential ...
Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lipid peroxidation [0.03%]
黄芩素A通过靶向ALOX12-脂质过氧化抑制脓毒症相关的凝血功能障碍
Dongsheng Bai,Jiachen Lu,Huishu Yang et al.
Dongsheng Bai et al.
Sepsis is a life-threatening syndrome driven by dysregulated thromboinflammation. Effective therapies are currently lacking due to the clinical limitations and bleeding risks associated with conventional anticoagulants. In this study, we de...
Reshaping the immunosuppressive niche in hepatocellular carcinoma: crosstalk networks, metabolic reprogramming, and therapeutic strategies [0.03%]
重塑肝细胞癌免疫抑制微环境：互作网络、代谢重编程及治疗策略
Yuting Zhang,Shizheng Xiong,Wanjie Zheng et al.
Yuting Zhang et al.
The liver tumor microenvironment plays a pivotal role in hepatocellular carcinoma (HCC) progression by fostering immune suppression, which impairs anti-tumor responses and enables tumor growth, invasion, and metastasis. This review integrat...
A resveratrol derivative RVX-208 inhibits PD-1/PD-L1 to restrain non-small cell lung cancer as an immunotherapy [0.03%]
白藜芦醇衍生产物RVX-208通过抑制PD-1/PD-L1对抗非小细胞肺癌的免疫疗法作用机制研究
Ziye Chen,Ruopeng Li,Fengsheng Chen et al.
Ziye Chen et al.
Immunotherapies, particularly anti-PD-1 antibodies, have emerged as standard first-line treatments for non-small cell lung cancer (NSCLC). RVX-208, derived from resveratrol, has recently completed Phase III clinical trials for atheroscleros...
miR-454-3p drives development of hepatic steatosis by negatively regulating JARID2 [0.03%]
微RNA-miR-454-3P通过抑制JARID2促进肝脂肪变性的机制研究
Ting Zhang,Ziyan Pan,Lijun Fan et al.
Ting Zhang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is caused by excessive fat accumulation in the liver. The previous study demonstrated that miR-454-3p was significantly upregulated in metabolic-related diseases type 2 diabet...