Hyperlipidemia impairs bone repair and regeneration via miR-193a-3p/STMN1/PI3K/Akt axis [0.03%]
高脂血症通过miR-193a-3p/STMN1/PI3K/Akt轴损害骨修复与再生
Jiaming Shang,Zechuan Li,Anquan Ma et al.
Jiaming Shang et al.
Hyperlipidemia, a metabolic disease characterized by excessive blood lipid, disturbs bone metabolism by shifting cell fate of bone marrow stromal cells (BMSCs) towards adipogenic differentiation, thus resulting in poor bone regeneration and...
AURKB and circAURKB_288aa enhance Esophageal cancer drug resistance through inducing abnormal centrosome separation [0.03%]
AURKB和circAURKB_288aa通过诱导异常中心体分离增强食管癌的耐药性
Hongzhen Lv,Jing Zhou,Limin Qiu et al.
Hongzhen Lv et al.
Esophageal cancer (EC) is one of the most fatal malignancies worldwide, with a dramatic increase in incidence in the western world occurring over the past few decades. Chromosome instability (CIN) is a major contributor to EC progression, d...
Erratum to "Activating transcriptional coactivator with PDZ-binding motif by (R)-PFI-2 attenuates osteoclastogenesis and prevents ovariectomized-induced osteoporosis" [Biochem. Pharmacol. 219 (2024) 115964] [0.03%]
关于“(R)-PFI-2激活含PDZ结合基序的转录共激活因子以抑制成骨细胞生成和预防卵巢切除术诱导的骨质疏松[Biochem. Pharmacol. 219 (2024) 115964]”的勘误说明
Rongjian Xu,Xuewen Liu,Yufeng Zhang et al.
Rongjian Xu et al.
Published Erratum
Biochemical pharmacology. 2024 Dec 4:232:116687. DOI:10.1016/j.bcp.2024.116687 2024
SIRT-2 inhibition by AK-7 orchestrates fibrotic cascades in airways through neuroimmune interaction via TRPA1, TRPM8 and TGF-β signalling [0.03%]
AK-7通过神经免疫相互作用抑制SIRT-2并通过TRPA1，TRPM8和TGF-β信号传导在气道中协调纤维化级联反应
Vandana Yadav,Vinita Pandey,Pratikkumar Gaglani et al.
Vandana Yadav et al.
Chronic obstructive pulmonary diseases (COPD) is characterized by airflow limitation, chronic inflammation and airway remodeling (AR) in airways and lung parenchyma. AR, a lung response, involves mucus production, airflow issues, and struct...
SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription [0.03%]
SMURF1通过丧失PATZ1诱导的CCNG2转录介导β-catenin信号促进食管鳞癌进展
Lingling Chen,Jie Tang,Yunli Chang et al.
Lingling Chen et al.
Cyclin G2 (CCNG2), a known inhibitor of cell cycle progression, has been identified as a suppressor for the canonical β-catenin pathway. This study explores the impact of CCNG2 on β-catenin activity and malignant characteristics of esopha...
Curcumin alleviates the aggressiveness of breast cancer through inhibiting cell adhesion mediated by TEAD4-fibronectin axis [0.03%]
姜黄素通过抑制TEAD4-纤连蛋白轴介导的细胞黏附来缓解乳腺癌侵袭性
Mengjie Li,Lihua Chen,Miao Wang et al.
Mengjie Li et al.
Breast cancer (BC) ranks first among women in the world and metastasis is the main reason of cancer death. TEA domain transcription factor 4 (TEAD4) plays an important role in TEAD family members in the Hippo signaling pathway, and its pro-...
Positive allosteric modulation of µ-opioid receptor - A new possible approach in the pain management? [0.03%]
μ-阿片受体正变构调节在疼痛管理中的新作用机制？
Wojciech Król,Weronika Machelak,Marta Zielińska
Wojciech Król
The antinociceptive effect of the opioid drugs is achieved through activation of the µ-opioid receptor (MOP). The orthosteric and allosteric sites of opioid receptors may be modulated, orthosteric site by endogenous i.e.β-endorphin and ex...
An analysis of single-cell data reveals therapeutic effects of AMG487 in experimental autoimmune uveitis [0.03%]
单细胞数据分析揭示了AMG487治疗实验性自身免疫性葡萄膜炎的疗效
Loujing Jiang,Runping Duan,Xiaoyang Yu et al.
Loujing Jiang et al.
Uveitis, an ocular autoimmune disease that poses a significant threat to vision, is caused by immune cells erroneously attacking retinal cells and currently lacks specific and effective therapeutic interventions. The CXC chemokine receptor ...
Shria Mattoo,Muskaan Arora,Priyanka Sharma et al.
Shria Mattoo et al.
Regulated protein degradation plays a crucial role in maintaining proteostasis along with protein refolding and compartmentalisation which collectively control biological functions. The N-end rule pathway is a major ubiquitin-dependent prot...
Isoginkgetin Inhibits RANKL-induced Osteoclastogenesis and Alleviates Bone Loss [0.03%]
异甘草素通过抑制RANKL诱导的破骨细胞生成治疗骨质疏松症
Zihe Wang,Wei Deng,Kai Tang et al.
Zihe Wang et al.
Osteoporosis is characterized by excessive osteoclast activity leading to bone loss, decreased bone mineral density, and increased susceptibility to fractures. Through in vivo/vitro experiments, along with network pharmacology analysis, we ...