Mechanism of action of REDD1 in depression and its targeted intervention [0.03%]
REDD1在抑郁发病中的作用机制及靶向干预研究
Wei Guan,Yu-Ting Meng,Yang Miao
Wei Guan
Depression is a chronic and recurrent mental disorder characterised by depressed mood, social isolation, and anhedonia. Despite its increasing prevalence, the underlying biological mechanisms, particularly those driven by genetic factors, r...
Finerenone improves doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte apoptosis through the TAK1-p38 axis [0.03%]
芬伦农通过TAK1-p38轴抑制心肌细胞凋亡来改善多柔比星诱导的心脏毒性
Xingyi Lai,Yu Wang,Jiaming Zhang et al.
Xingyi Lai et al.
Although doxorubicin (DOX) is a potent chemotherapeutic agent, its clinical use is limited by dose-dependent cardiotoxicity. Doxorubicin-induced cardiotoxicity (DIC) promotes cardiomyocyte apoptosis, which leads to cardiac dysfunction, remo...
Ginkgetin alleviates cisplatin-induced muscle atrophy via inhibition of the macrophage cGAS-STING pathway [0.03%]
银杏内酯通过抑制巨噬细胞cGAS-STING通路缓解顺铂诱导的肌肉萎缩
Xiaojing Chen,Jianwei Lin,Jingchun Lv et al.
Xiaojing Chen et al.
Chemotherapy-induced muscle atrophy is a severe side effect, impairing patients' quality of life and overall survival. However, the persistence of muscle atrophy in cancer survivors long after treatment completion suggests that it is driven...
Epitranscriptomic signatures of malignancy: how RNA modifications shape breast and ovarian tumor progression [0.03%]
表观转录组标志在恶性肿瘤中的作用：RNA修饰如何影响乳腺癌和卵巢癌的发展进展
Pankaj Garg,Ravi Salgia,Sharad S Singhal
Pankaj Garg
Breast and ovarian cancers are still one of the most prevalent causes of cancer death among the women in all parts of the world, mostly occurring at a later stage with high recurrence rate and resistance to treatment. Beyond the well-known ...
Lycorine protects against inflammatory hemorrhagic skin injury via suppression of neutrophil-driven NADPH oxidase activation [0.03%]
石蒜碱通过抑制中性粒细胞驱动的NADPH氧化酶活化来预防炎症性出血性皮肤损伤
Yunduan Song,Yaoshuai Zhang,Huixing Li et al.
Yunduan Song et al.
Lycorine (LYC) , an alkaloid derived from Amaryllidaceae plants, exhibits broad biological activities, including anti-inflammatory, antiviral, and antitumor effects. However, its role in inflammatory hemorrhagic skin diseases and whether LY...
The dual role of formyl peptide receptor 1 (FPR1) in gastrointestinal inflammation and carcinogenesis: mechanisms and therapeutic implications [0.03%]
形式肽受体1(FPR1)在胃肠炎症和肿瘤发生中的双重作用：机制及治疗意义
Yuanding Bai,Yu Hu,Linzhen Li et al.
Yuanding Bai et al.
Formyl Peptide Receptor 1 (FPR1), a Class A G protein-coupled receptor (GPCR), is a context-dependent regulator at the interface of gastrointestinal inflammation and cancer. Recent structural insights have revealed its functional diversity....
Lycorine suppresses cell growth and attenuates stemness through PI3K/AKT pathway in ovarian cancer [0.03%]
石蒜碱通过抑制PI3K / AKT信号通路抑制卵巢癌细胞的生长和干性
Yaoyao Tan,Liping Xia,Guanlin Dai et al.
Yaoyao Tan et al.
Ovarian cancer remains the most lethal gynecological malignancy worldwide, largely owing to poor prognosis associated with chemotherapy resistance and cancer stem cell-driven recurrence. This study comprehensively investigates the antitumor...
Evaluation of small molecule PD-1/PD-L1 inhibitors in a T cell reporter system [0.03%]
基于T细胞报告系统的PD-1/PD-L1小分子抑制剂的筛选及验证研究
Judith Leitner,Helene Schindler,Simon Gumpelmair et al.
Judith Leitner et al.
Antibodies that block PD-1 signaling, known as immune checkpoint inhibitors (ICIs), have revolutionized cancer treatment. Small molecule inhibitors of the PD-1/PD-L1 interaction could serve as promising alternatives to antibody-based ICIs, ...
Macrophages at the Core: Metabolic shifts and renal cell cross-talk as key mediators in diabetic nephropathy [0.03%]
巨噬细胞的核心作用：代谢转换和肾细胞相互作用在糖尿病肾病中的关键介导作用
Yi Song,Linxin Ye,Hang Zhou et al.
Yi Song et al.
Diabetic nephropathy (DN) remains a major cause of end-stage renal disease, driven by chronic immune activation and metabolic imbalance. Macrophages act as central regulators, undergoing multidimensional reprogramming across glucose, lipid,...
Corrigendum to "Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways" [Biochem. Pharmacol. 223 (2024) 116132] [0.03%]
关于“抑制CISD1通过PI3K和MAPK途径缓解小鼠顺铂引起的听力损失”一文的勘误[Biochem. Pharmacol. 223 (2024) 116132]
Wenqi Dong,Yumeng Jiang,Qingxiu Yao et al.
Wenqi Dong et al.
Published Erratum
Biochemical pharmacology. 2026 Mar 7:248:117844. DOI:10.1016/j.bcp.2026.117844 2026