Hb Vanvitelli: A new unstable α-globin chain variant causes undiagnosed chronic haemolytic anaemia when co-inherited with deletion - α3.7 [0.03%]
Vanvitelli Hb变异所致的慢性溶血性贫血伴有α珠蛋白缺失-α3.7基因型杂合子状态的研究
Maddalena Casale,Flora Cozzolino,Saverio Scianguetta et al.
Maddalena Casale et al.
Hb variants are structurally abnormal haemoglobins which can originate a wide range of phenotypes from clinically silent conditions to very severe disorders. In many cases, diagnosis is very difficult due to the instability of Hb mutants or...
PCSK9 and atherosclerosis burden in the coronary arteries of patients undergoing coronary angiography [0.03%]
PCSK9与冠脉造影患者的冠状动脉粥样硬化病变关系的研究
Yunes Panahi,Mohsen Sadeghi Ghahrodi,Mohsen Jamshir et al.
Yunes Panahi et al.
Aims: To investigate the association between plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations, current acute coronary syndrome (ACS), coronary artery disease (CAD) presence, severity and extensi...
Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data [0.03%]
基于真实世界大数据的性别、年龄和季节性甲状腺球蛋白抗体和甲状腺过氧化物酶抗体界值及影响效应研究
Chaochao Ma,Dandan Li,Yicong Yin et al.
Chaochao Ma et al.
Background: Thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) are cornerstone biomarkers for autoimmune thyroid diseases, and establishment of appropriate thresholds is crucial for physicians to appr...
Best practices in mitigating the risk of biotin interference with laboratory testing [0.03%]
生物素干扰实验室检测的风险防控措施最佳实践建议
Raffick Bowen,Raul Benavides,Jessica M Colón-Franco et al.
Raffick Bowen et al.
Dietary biotin intake does not typically result in blood biotin concentrations that exceed interference thresholds for in vitro diagnostic tests. However, recent trends of high-dose biotin supplements and clinical trials of very high biotin...
José D Santotoribio,Consuelo Cañavate-Solano,Rocío Quintero-Prado et al.
José D Santotoribio et al.
Background: S100B protein is one of the most accurate biomarkers for diagnosis of neuroapoptosis and brain damage. The aim was to evaluate the lactate concentration and acid-base balance (pH, pCO2, pO2, HCO3c and BEb) in ...
Continuous reference intervals for 38 biochemical markers in healthy children and adolescents: Comparisons to traditionally partitioned reference intervals [0.03%]
健康儿童和青少年38种生化标志物的连续参考区间：与传统分区参考区间的比较
Shervin Asgari,Victoria Higgins,Christopher McCudden et al.
Shervin Asgari et al.
Background: Reference intervals have traditionally been partitioned by age based on statistical significance and physiological relevance. However, analyte concentration does not change abruptly with age, but rather dynami...
Clinical Trial
Clinical biochemistry. 2019 Nov:73:82-89. DOI:10.1016/j.clinbiochem.2019.08.010 2019
Association between FSH, E1, and E2 levels in urine and serum in premenopausal and postmenopausal women [0.03%]
绝经前和绝经后女性尿液和血液中FSH、E1和E2水平的相关性研究
Yoko Onizuka,Kazue Nagai,Yuki Ideno et al.
Yoko Onizuka et al.
Objective: We aimed to establish correlations for the levels of follicle-stimulating hormone (FSH), estrone (E1) and estradiol (E2) between urine and serum in premenopausal and postmenopausal women using immunoassays. ...
Giulia Sancesario,Sergio Bernardini
Giulia Sancesario
Core Alzheimer's Disease (AD) biomarkers are the cerebrospinal fluid (CSF) proteins amyloid β42 and β40, and the tau proteins, total and phosphorylated. Their use is recommended by research guidelines for diagnostic purpose and for strati...
Rising above helium: A hydrogen carrier gas chromatography flame ionization detection (GC-FID) method for the simultaneous quantification of toxic alcohols and ethylene glycol in human plasma specimens [0.03%]
一种用于同时定量人血浆标本中毒性醇和乙二醇的氢气载气气相色谱-火焰离子化检测法（GC-FID）
Joshua Buse,Jason L Robinson,Rosemary Shyne et al.
Joshua Buse et al.
Here we validate a GC, Flame Ionization Detection (GC-FID), liquid injection method using hydrogen as a carrier gas combining analysis of toxic volatile alcohols (VA): methanol, ethanol, isopropanol, acetone, as well as glycols, ethylene gl...
Proteomics analysis of blood plasma in HIV-infected patients with chronic kidney disease [0.03%]
HIV感染伴慢性肾脏病患者血浆蛋白质组学分析
Amanda Anne Lavinya,Cheng Siang Lee,Onn Haji Hashim et al.
Amanda Anne Lavinya et al.
Background: Patients treated for human immunodeficiency virus (HIV) infection are prone to developing chronic kidney disease (CKD). Current methods used in assessing kidney function suffer inaccuracy in HIV-infected patie...
Clinical Trial
Clinical biochemistry. 2019 Nov:73:90-97. DOI:10.1016/j.clinbiochem.2019.08.006 2019