Utility of biomarkers of ethanol metabolism in differentiating auto-brewery syndrome from alcohol use [0.03%]
区分自酿酒综合症和酒精使用的乙醇代谢生物标志物的实用性
John A Damianos
John A Damianos
Auto-brewery syndrome (ABS) is a rare disorder featuring episodes of intoxication caused by intestinal fermentation of dietary carbohydrates into ethanol. This article presents the case of a patient referred for evaluation of ABS. He underw...
Molecular and biochemical correlates of urinary composition in kidney stone pathogenesis [0.03%]
肾脏结石发病过程中尿液成分的分子和生化特征
Malti,RImpa Manna,Arpit Bhargava
Malti
Kidney stone disease is one of the most common urological problems worldwide, with a high rate of recurrence. Even though surgical and medical treatments are available, many patients develop stones again due to underlying metabolic and bioc...
High-value laboratory testing in erectile dysfunction, reduced sexual desire, and suspected hypogonadism: analytical pitfalls and selective biomarker use [0.03%]
男性性功能障碍、低性欲和疑似低睾酮血症的实验室检测陷阱及特异性生物标志物选择分析
Marek Broul,Petr Kelbich,Adéla Jizerová et al.
Marek Broul et al.
In men presenting with erectile dysfunction, reduced sexual desire, or suspected hypogonadism, laboratory work-up frequently oscillates between indiscriminate hormone panels and underuse of high-yield metabolic testing. From a clinical bioc...
Establishment of PCOS-specific prolactin reference intervals to optimize laboratory demand management for macroprolactin screening [0.03%]
多囊卵巢综合征特异性催乳素参考区间的确立以优化巨催乳素筛查的实验室需求管理
Sanz-Felisi María,Durán-Espín Sofía,Tauler-Quetglas Paula et al.
Sanz-Felisi María et al.
Background and aim: Women with polycystic ovary syndrome (PCOS) often have elevated prolactin serum concentrations. This can lead to unnecessary macroprolactin screening and diagnostic confusion. This study aimed to estab...
Modest sensitivity of 24 h urine free cortisol LC-MS/MS to detect Cushing's disease [0.03%]
24小时尿游离皮质醇LC-MS/MS法检测库欣病的敏感度较低
Kirstie C Lithgow,Jennifer A Mann,Yves Starreveld et al.
Kirstie C Lithgow et al.
Purpose: Cushing's disease (CD) is a rare disorder of endogenous hypercortisolism arising from a corticotroph adenoma and is associated with significant morbidity and mortality. Measurement of 24-h urine free cortisol (UF...
Choosing wisely-directed HFE testing improves diagnostic yield and test utilization in hereditary hemochromatosis [0.03%]
明智选择HFE定向检测可提高遗传性血色病诊断效率及检测应用率
Landry E Nfonsam,Betty-Ann Hohenadel,Menaka Pai et al.
Landry E Nfonsam et al.
Background: Appropriate laboratory test utilization is essential for sustainable clinical and laboratory practice. HFE-associated hereditary hemochromatosis is a common cause of iron overload in individuals of Northern Eu...
Cryoglobulinemia and Cryofibrinogenemia: Ten years of experience and diagnostic perspectives from a large laboratory-based cohort [0.03%]
冷球蛋白血症和冷纤维蛋白原血症：来自大型实验室队列的十年经验及诊断视角
Patrizia Natali,Daria Debbia,Cecilia Napodano et al.
Patrizia Natali et al.
Objectives: Cryoproteins include cryoglobulins (CG), detectable in serum and plasma, and cryofibrinogen (CF), detectable only in plasma. Although they share clinical features, CG and CF differ in pathogenesis and diagnost...
Spuriously elevated estradiol due to immunoassay interference in the workup of a suspected ovarian tumor: Diagnostic pitfalls and laboratory workflow recommendations [0.03%]
免疫测定交叉反应导致卵巢疑似肿瘤检测中雌二醇假性升高：诊断陷阱和实验室工作流程建议
Gelsy Arianna Lupoli,Carmela Polito,Giuseppe Jannuzzi et al.
Gelsy Arianna Lupoli et al.
Background: Falsely elevated estradiol levels due to analytical interference are rare but clinically relevant diagnostic pitfalls, particularly when results suggest an estrogen-producing tumor. ...
G6PD activity in pediatric patients with the G6PD Ilesha variant: A case series G6PD Ilesha variant in Pediatric patients [0.03%]
儿科患者的G6PD伊西莎变异型活性：系列病例报告
Katherine M Robinson,Meghan D McNulty,Kristine R Crews et al.
Katherine M Robinson et al.
Background: Patients with glucose-6-phosphate deficiency exposed to oxidative triggers may develop hemolytic anemia. The G6PD Ilesha variant (NM_001042351.3: c.466G > A p.Glu156Lys) is a rare variant that is currently cat...
The contribution of patient travel for phlebotomy to the carbon footprint of clinical laboratories [0.03%]
患者到医院抽血对临床实验室碳排放的贡献
Christopher Naugler,Deirdre Church
Christopher Naugler
Context: Healthcare contributes approximately 5% of global greenhouse gas emissions, yet the carbon footprint of clinical laboratory activity has been studied almost entirely from the perspective of laboratory operations ...