The biological diagnosis of Alzheimer's disease using blood-based biomarkers: a Canadian prospective [0.03%]
基于血液生物标志物的阿尔茨海默病生物学诊断：一项加拿大的前瞻性研究
Pankaj Kumar,Ali Mousavi,Hans Frykman
Pankaj Kumar
Dementia is the most common type of neurodegenerative disease, with Alzheimer's Disease (AD) constituting about two-thirds of these cases. In Canada, an estimated 674,000 individuals may have AD by 2031, nearly doubling from 2011. The total...
Published Erratum
Clinical biochemistry. 2025 Sep 29:111015. DOI:10.1016/j.clinbiochem.2025.111015 2025
Calculated small-dense and large-buoyant low-density lipoprotein-cholesterol and their ratio in predicting coronary artery disease risk: A cohort study in Thailand [0.03%]
计算出的小而密和大而轻低密度脂蛋白胆固醇及其比值在预测冠心病风险中的作用：泰国的一项队列研究
Thanyatorn Chantivas,Prin Vathesatogkit,Anchalee Chittamma et al.
Thanyatorn Chantivas et al.
Objectives: Calculated, small dense low-density lipoprotein cholesterol (CsdLDL-C), derived using the Sampson equation, has been proposed as a screening tool for atherosclerotic cardiovascular disease risk. The current st...
Modified LDL variants in atherosclerosis: molecular pathways, diagnostic potential, and therapeutic perspectives [0.03%]
动脉粥样硬化中修改的LDL变异体：分子通路、诊断潜力和治疗观点
Siarhei A Dabravolski,Alexander L Golovyuk,Olga N Maltseva et al.
Siarhei A Dabravolski et al.
Modified low-density lipoproteins (LDL) play a pivotal role in the pathogenesis of atherosclerosis, contributing to plaque formation and vascular inflammation. This review explores how a diverse array of forms of modified LDL, including car...
Reliable LC-MS/MS method development and validation for the determination of methylmalonic acid, methylcitric acid, malonic acid, ethylmalonic acid, and total homocysteine in dried blood spots [0.03%]
用于测定干血点中甲基丙二酸、甲基柠檬酸、琥珀酸、乙基丙二酸和总同型半胱氨酸的可靠LC-MS / MS方法的开发与验证
Chunyan Zhang,Nan Bai,Yanling Yang et al.
Chunyan Zhang et al.
Objectives: Metabolic disorders in newborns can cause significant morbidity and mortality if not diagnosed and managed early. In this study, we developed and validated a reliable LC-MS/MS method to simultaneously quantify...
Assessment of structural and functional characteristics of HDL and LDL in lung cancer patients in order to elucidate mechanisms of cholesterol metabolic pathways disorders [0.03%]
评估肺癌患者HDL和LDL的结构和功能特征以阐明胆固醇代谢途径紊乱机制
Milica Belic,Dragana Jovanovic,Milica Miljkovic Trailovic et al.
Milica Belic et al.
Introduction: Cholesterol metabolism dysregulation is recognized as one of the hallmarks of the cancer with highest mortality rate and the second most common malignancy - lung cancer (LC). LDL and HDL particles, the latte...
Urine proteome uncovers common mechanisms between mucopolysaccharidosis types I and II [0.03%]
尿蛋白组揭示I型和II型黏多糖贮积症的共同机制
Xiaozhou Yuan,Donghao Jia,Gefan Wan et al.
Xiaozhou Yuan et al.
Background and aims: Mucopolysaccharidosis (MPS) types I and II are two types of rare lysosomal storage diseases, which lead to the accumulation of glycosaminoglycans due to the lack of the enzyme alpha-L-iduronidase and ...
Phenotyping and genotyping for the dihydropyrimidine dehydrogenase test in Italy: a precise diagnostic strategy to detect rare variants and improve drug administration [0.03%]
意大利二氢嘧啶脱氢酶检测表型和基因分型：一种精确的诊断策略，用于识别罕见变异并改进药物使用
Maria Lucia Tommolini,Mirco Zucchelli,Alberto Frisco et al.
Maria Lucia Tommolini et al.
Introduction: Dihydropyrimidine dehydrogenase (DPD) is the enzyme implicated in the catabolism of the fluoropyrimidines (FP), a class of chemotherapeutics used to treat many cancers. The DPYD gene is known to have a huge ...
Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome [0.03%]
卵泡液中血小板因子4水平升高与多囊卵巢综合征有关
Wenqi Wang,Guangxi Wang,Xiaoming Niu et al.
Wenqi Wang et al.
Objective: This present study aimed to measure platelet factor 4 (PF4) protein level in follicular fluid of patients with polycystic ovary syndrome (PCOS) and analyzed the correlation between follicular PF4 level with cli...
Clinical implementation and outcome evaluation of dihydropyrimidine dehydrogenase (DPYD) pharmacogenomic testing for fluoropyrimidine dosing in a Canadian Provincial Healthcare center [0.03%]
二氢嘧啶脱氢酶（DPYD）药物基因组学检测在氟尿嘧啶类药物剂量调整中的临床应用及疗效评估：加拿大省级医疗中心报告
Fang Wu,Song Lu,Dan Zhang et al.
Fang Wu et al.
Background: 5-Fluorouracil (5-FU) and its pro-drug, capecitabine, are widely used to treat solid tumors. Patients with dihydropyrimidine dehydrogenase (DPYD) deficiency are at increased risk for severe treatment-related t...
Leyla Karimova,Gulnara Azizova,Ilaha Shahverdiyeva
Leyla Karimova
Objective: Breast cancer (BC) remains a leading cause of morbidity and mortality among women globally. This study aims to investigate HER2 mutations in HER2-negative BC and evaluate the diagnostic potential of matrix meta...